Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial
説明 | A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial |
ターゲット&IC50 | α7 nAChR:10.8 nM (Ki, for rat α7 receptors), α7 nAChR:16.7 nM (Ki, for human α7 receptors), 5-HT3 receptor:150 nM (Ki) |
In vivo | A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs.?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function. |
別名 | A 582941 |
分子量 | 353.29 |
分子式 | C17H22Cl2N4 |
CAS No. | 848591-90-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (196.17 mM)
You can also refer to dose conversion for different animals. 詳細
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A-582941 dihydrochloride 848591-90-2 GPCR/G Protein Neuroscience 5-HT Receptor AChR A-582941 Dihydrochloride Serotonin Receptor psychiatric 5-HT3 deficits A 582941 Dihydrochloride Inhibitor A582941 dihydrochloride A582941 Dihydrochloride A-582941 Nicotinic acetylcholine receptors neurodegenerative A 582941 nAChR A582941 5-hydroxytryptamine Receptor partial cognitive A 582941 dihydrochloride inhibit inhibitor