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T15799 |
LY2940094
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LY-2940094 |
Opioid Receptor
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LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist pot... |
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T9288 |
Keratin hydrolyzed
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Others
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Keratin hydrolyzed is a processed form of keratin that allows it to penetrate the hair cuticle. |
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TP1185L |
Cys-TAT(47-57) acetate(583836-55-9 Free base)
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Cys-TAT(47-57) acetate（583836-55-9 Free base） |
HIV Protease
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Cys-TAT(47-57) acetate is derived from the HIV-1 transactivating protein. Cys-TAT(47-57) acetate is an arginine rich peptide that can penetrate cells. |
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T6107 |
IU1
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DUB
,
Autophagy
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IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell. |
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T5397 |
A-381393
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Dopamine Receptor
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A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor). |
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T60644 |
SJ000063181
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TGF-beta/Smad
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SJ000063181 is a potent activator of BMP signaling, exhibiting an EC50 of ≤1 μM. It serves as a valuable chemical probe for BMP signaling analysis, owing to its ability to penetrate zebrafish embryos. |
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T2335 |
Ebastine
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Ebastel,LAS-W 090,Ebastin,Kestine,RP64305 |
Histamine Receptor
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Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tiss... |
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T5058 |
Pamiparib
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BGB-290 |
PARP
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Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor(IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively). It has potent PARP trapping, and capability to penetrate the brain, and can b... |
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T0402 |
Octocrylene
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Octocrilene |
Others
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Octocrylene (Octocrilene) is used as an ingredient in sunscreens and cosmetics. This organic compound can penetrate into the skin where it acts as a photosensitizer. This results in an increased production of free radica... |
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T10202 |
A 1070722
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GSK-3
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T23046 |
N-tert-butyl-α-Phenylnitrone
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(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide |
ROS
,
COX
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N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxyge... |
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T6726 |
VU0361737
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ML-128,VU 0361737 |
GluR
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VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity... |
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T26684 |
Auten-99 HBr
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Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99 |
Phosphatase
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Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate th... |
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T5465 |
PF-5274857
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PF-5274857 freebase |
Smo
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PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t... |
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T68527 |
Temelastine
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|
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Temelastine is a selective, competitive histamine H1-receptor antagonist which does not penetrate the central nervous system. |
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T14938 |
CGP 36742
|
SGS-742 |
GABA Receptor
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CGP 36742 is a selective antagonist of the GABAB receptor that can penetrate the blood-brain barrier after peripheral administration (IC50: 32 μM). It is useful in the treatment of depression. |
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T37406 |
Apovincaminic acid hydrochloride salt
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Apovincaminic acid hydrochloride salt, the primary active metabolite of Vinpocetine (VP), is orally active and has the ability to penetrate the brain. It demonstrates a neuroprotective mechanism of action [1][2]. |
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T18932 |
Calcein tetraethyl ester
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Fluorexon tetraethyl ester |
Others
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Calcein tetraethyl ester, a fluorescent dye, is utilized in biological studies for its ability to penetrate cellular membranes into living cells. This property renders it valuable for assessing cell viability and short-t... |
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T82345 |
Galanin-B2
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NAX-5055 |
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Galanin-B2 (NAX-5055) demonstrates activity in epilepsy models and possesses the ability to penetrate the blood-brain barrier [1]. |
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T61666 |
SUN13837
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SUN13837 is an orally active, potent modulator of the fibroblast growth factor receptor (FGFR) with the ability to penetrate the blood-brain barrier (BBB). It exhibits neuroprotective activity and holds promise for furth... |
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T12861L |
SB-277011 dihydrochloride
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SB-277011A dihydrochloride |
Dopamine Receptor
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SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
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T11323L |
Frakefamide
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Others
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Frakefamide is a potent analgesic that functions as a peripheral active μ-selective receptor agonist. It cannot penetrate the blood-brain barrier to enter the central nervous system. |
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T61290 |
P163-0892
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P163-0892 is a highly effective and specific antifungal compound targeting Cryptococcus species. Additionally, P163-0892 demonstrates moderate capability to penetrate the blood-brain barrier [1]. |
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T40428 |
TfR-T12
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TfR-T12 |
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TfR-T12 is a transferrin receptor (TfR) binding peptide that can penetrate the blood-brain barrier (BBB), exhibiting a high binding affinity within the nanomolar (nM) range. |
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TP1709 |
TAT-amide
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TAT-amide is a cell-penetrating peptide (CPP) that exhibits the ability to enter various cells. CPPs, which are composed of short amino acid sequences, possess the capability to penetrate cell membranes and access intrac... |
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T81307 |
RE-33
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RE-33 is an analgesic compound with the ability to penetrate the blood-brain barrier [1]. |
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T40248 |
JNK3 inhibitor-1
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JNK3 inhibitor-1 |
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JNK3 inhibitor-1 is a highly potent and selective compound that specifically inhibits JNK3 with an impressive IC50 value of 0.005 μM. In addition to its remarkable inhibitory effects, JNK3 inhibitor-1 possesses excellent... |
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T61528 |
FGFR-IN-7
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FGFR-IN-7 (compound 17) is an orally active, potent FGFR modulator with the ability to penetrate the blood-brain barrier. It exhibits neuroprotective properties, enhancing brain exposure and decreasing the likelihood of ... |
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T69768 |
WSD0922-FU
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WSD0922-FU is a blood-brain-barrier (BBB) penetrable selective inhibitor of epidermal growth factor receptor (EGFR) and various EGFR mutations, including but not limited to the EGFR variant III (EGFRvIII) mutant form, wi... |
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T69798 |
4-Me-PDTic HCl
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4-Me-PDTic is a potent and selective Kappa Opioid Receptor Antagonist. 4-Me-PDTic had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors,... |
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T80972 |
TNH
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TMP-NVOC linker-Halo |
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TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1]. |
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T61609 |
CB1-IN-2
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CB1-IN-2 (Compound 4g) is a potent and selective inhibitor of the CB1 receptor, exhibiting an IC50 value of 0.644 μM. This compound possesses the ability to penetrate the blood-brain barrier and has the potential to indu... |
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T39781 |
Aβ/tau aggregation-IN-1
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Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ 1-42 β-sheet formation and tau aggregation. It exhibits K D values of 160 μM and 337 μM with Aβ 1-42 and tau, respectively. Additionally, Aβ/tau aggregation-IN-1 can pe... |
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T39492 |
FRM-024
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FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment of familial Alzheimer's disease. |
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T11323 |
Frakefamide TFA (188196-22-7 free base)
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Frakefamide TFA |
Others
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Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system. Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. |
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T61679 |
Abacavir monosulfate
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Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, a... |
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T61427 |
Lamivudine salicylate
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Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that effectively inhibits the reverse transcriptase activity of both HIV 1/2 and hepatitis B virus. Moreover, it demon... |
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T61497 |
Rho-Kinase-IN-2
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Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC5... |
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T81034 |
TAT-NSF700 Fusion Peptide
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TAT-NSF700 Fusion Peptide, a potent inhibitor of N-ethyl-maleimide-sensitive factor (NSF), possesses the ability to penetrate cell membranes and directly interact with intracellular organelles [1]. |
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T61660 |
FGFR-IN-3
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FGFR-IN-3 (compound 6) is a highly potent and orally active modulator of FGFR (fibroblast growth factor receptor). It has the ability to penetrate the blood-brain barrier (BBB). Additionally, FGFR-IN-3 exhibits significa... |
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T61788 |
TRPV1 antagonist 3
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TRPV1 antagonist 3 (Compound 7q) is a highly potent antagonist of the TRPV1 receptor with an IC50 of 2.66 nM against capsaicin. It exhibits selectivity towards its mode of action and is orally bioavailable (with a bioava... |
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T62586 |
Cav 2.2/3.2 blocker 1
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Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker that acts on Cav2.2 (IC50: 1.22 μM) and Cav3.2 (IC50: 80 μM). Can penetrate the central nervous system. |
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T78025 |
LQVTDSGLYRCVIYHPP
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LQVTDSGLYRCVIYHPP (LP17) is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that mitigates ischemia-induced infarction and neuronal damage. It can penetrate the brain and inhibit TREM-1 [1]. |
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T74613 |
G-quadruplex DNA fluorescence probe 1
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Compound E1, also known as G-quadruplex DNA fluorescence probe 1, is a selective fluorescent probe targeting G-quadruplex DNA. It possesses the ability to penetrate membranes and enter living cells, demonstrating low cyt... |
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T28400 |
Phenoprolamine Hydrochloride
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phenoprolamine,DDPH |
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Phenoprolamine Hydrochloride is an adrenergic α1 receptor antagonist with potent antihypertensive, neuroprotective and cardioprotective effects. Phenoprolamine Hydrochloride inhibits CYP2D and CYP3A activities and down-r... |
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T61227 |
NAB-14
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NAB-14 is a powerful and selective chemical compound that acts as a non-competitive antagonist for GluN2C and GluN2D receptors. With an IC50 value of 580 nM for GluN1/GluN2D, NAB-14 demonstrates high potency. This compou... |
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T79539 |
Topoisomerase II inhibitor 16
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Topoisomerase
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Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the ability to penetrate the brain and stabilize double-stranded D... |
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T73187 |
BuChE-IN-7
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BuChE-IN-7 is a selective inhibitor targeting human butyrylcholinesterase (hBuChE) and equine butyrylcholinesterase (eqBuChE), demonstrating IC50 values of 40 nM and 80 nM, respectively. Demonstrating the ability to pene... |
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T80212 |
Lunasin
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Parasite
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Lunasin, a bioactive peptide derived from soybean, exhibits antioxidant, anti-inflammatory, anticancer, and anti-aging properties. It operates through an epigenetic mechanism linked to histone acetylation and has the abi... |
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T61693 |
AAK1-IN-5
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AAK1-IN-5 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), characterized by its ability to penetrate the central nervous system and its oral bioavailability. It displays high selectivit... |
