Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lasofoxifene Tartrate (CP-336156) is a third-generation, non-steroidal selective estrogen receptor modulator.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 12,500 | |||
10 mg | 在庫あり | ¥ 16,500 | |||
25 mg | 在庫あり | ¥ 32,500 | |||
50 mg | 在庫あり | ¥ 59,000 | |||
100 mg | 在庫あり | ¥ 76,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,500 |
説明 | Lasofoxifene Tartrate (CP-336156) is a third-generation, non-steroidal selective estrogen receptor modulator. |
In vivo | Lasofoxifene (LAS) and BZA reduced the clinical severity of arthritis as well as the grade of histologic synovitis and erosions on cartilage and bone.?Moreover, SERMs protected against generalised bone loss in CIA by increasing trabecular BMD.?Both SERMs decreased serum marker of cartilage destruction and LAS reduced serum IL-6 levels.?SERMs did not alter Th17 cells in lymph nodes as E2 did[1]. |
動物実験 | Female DBA/1 mice were ovariectomised and subjected to CIA as a model of post-menopausal RA. Mice received treatment with Lasofoxifene (LAS), BZA, 17β-estradiol (E2) as reference or vehicle. Arthritis development was assessed and BMD was determined by peripheral quantitative CT of the femurs. Serologic markers of inflammation and cartilage destruction were analysed. Immune cells in lymph nodes were studied by flow cytometry[1]. |
別名 | CP-336156 |
分子量 | 563.64 |
分子式 | C32H37NO8 |
CAS No. | 190791-29-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (10.65 mM)
You can also refer to dose conversion for different animals. 詳細
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Lasofoxifene Tartrate 190791-29-8 Endocrinology/Hormones Estrogen Receptor/ERR osteoporosis inhibit CP-336156 arthritis endocrine resistant breast cancer CP 336156 Inhibitor selective oestrogen receptor modulators tartrate oestrogen CP336156 Lasofoxifene inhibitor