Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 13,000 | |||
25 mg | 在庫あり | ¥ 20,000 | |||
50 mg | 在庫あり | ¥ 26,000 | |||
100 mg | 在庫あり | ¥ 45,500 | |||
200 mg | 在庫あり | ¥ 79,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis. |
In vitro | Lodoxamide effectively inhibits histamine release induced by compound 48/80 and reduces 45Ca influx triggered by ionophores, accompanied by a decrease in histamine release in purified rat peritoneal mast cells [1]. Moreover, it significantly and dose-dependently suppresses eosinophil chemotaxis towards fMLP and IL-5. Additionally, Lodoxamide robustly inhibits the release of eosinophil peroxidase following IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin [2]. |
In vivo | Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anaesthetized rhesus monkeys [1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation decreased microvascular permeability, and increased compliance [3]. |
別名 | Lodoxamidum |
分子量 | 311.63 |
分子式 | C11H6ClN3O6 |
CAS No. | 53882-12-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Lodoxamide 53882-12-5 Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Neuroscience GPR Histamine Receptor Lodoxamidum Inhibitor inhibit U-42585E inhibitor