Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 10,000 | |||
10 mg | 在庫あり | ¥ 12,500 | |||
25 mg | 在庫あり | ¥ 22,000 | |||
50 mg | 在庫あり | ¥ 37,500 | |||
100 mg | 在庫あり | ¥ 68,500 | |||
500 mg | 在庫あり | ¥ 170,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) . |
ターゲット&IC50 | MGMT:5 nM |
In vitro | In the A375M human melanoma xenograft model, intraperitoneal injection of Lomeguatrib (20 mg/kg) treatment was found to inhibit ATase activity. |
In vivo | In Raji cells, Lomeguatrib inhibits ATase activity with an IC50 value of 10 nM, while in MCF-7 cells, it effectively inhibits MGMT with an IC50 of 6 nM. |
別名 | PaTrin-2 |
分子量 | 326.17 |
分子式 | C10H8BrN5OS |
CAS No. | 192441-08-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 60 mg/mL (184 mM)
You can also refer to dose conversion for different animals. 詳細
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Lomeguatrib 192441-08-0 Chromatin/Epigenetic DNA Damage/DNA Repair DNA Alkylation DNA Methyltransferase inhibit DNMTs PaTrin 2 DNA MTases PaTrin-2 PaTrin2 Inhibitor inhibitor