Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 15,500 | |||
5 mg | 在庫あり | ¥ 37,500 | |||
10 mg | 在庫あり | ¥ 66,500 | |||
25 mg | 在庫あり | ¥ 123,500 | |||
50 mg | 在庫あり | ¥ 178,500 | |||
100 mg | 在庫あり | ¥ 250,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 40,000 |
説明 | CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor. |
ターゲット&IC50 | DNMT3B:1200 nM (IC50), G9a:8 nM, GLP:2 nM, DNMT3A:85 nM, DNMT1:382 nM |
In vitro | CM-272, inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models. |
In vivo | CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models.Induced a statistically significant increase in overall survival (OS) in mice. |
細胞研究 | Cell Line:CEMO-1, MV4-11 and OCI-Ly10 cell lines. Concentration:125 nM, 250 nM, 500 nM (CEMO-1 cells); 135 nM, 270 nM, 540 nM (MV4-11 cells); 100 nM, 400 nM, 1000 nM (OCI-Ly10 cells). Incubation Time:12 hours, 24 hours, 48 hours and 72?hours |
動物実験 | CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models. Animal Model:Female BALB/Ca-Rag2?/?γc?/? mice (6–8-week-old) with CEMO-1 cells. Dosage:2.5 mg/kg. Administration:Intravenous injection; daily; for 28 days |
分子量 | 478.63 |
分子式 | C28H38N4O3 |
CAS No. | 1846570-31-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 96 mg/mL (200.57 mM)
Ethanol: 96 mg/mL (200.57 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CM-272 1846570-31-7 Apoptosis Chromatin/Epigenetic Histone Methyltransferase DNA Methyltransferase DNMT1 anti-tumour DNMTs immunogenic DNA MTases DNMT3A G9a H3K9me2 Inhibitor epigenetics GLP inhibit substrate-competitive DNMT3B CM272 CM 272 inhibitor