Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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25 mg | 在庫あり | ¥ 8,000 | |||
50 mg | 在庫あり | ¥ 10,500 | |||
100 mg | 在庫あり | ¥ 15,500 | |||
200 mg | 在庫あり | ¥ 21,500 | |||
500 mg | 在庫あり | ¥ 35,500 | |||
1 g | 在庫あり | ¥ 52,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 7,000 |
説明 | Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol. |
ターゲット&IC50 | HMG-CoA reductase:3.4 nM |
In vivo | Lovastatin, initially an inactive lactone, undergoes hydrolysis in the liver to become an active β-hydroxyacid. This key metabolite acts as an inhibitor of HMG-CoA reductase enzyme, with a Ki of 1 nM, exhibiting strong binding to human plasma proteins. Both lovastatin and its β-hydroxyacid metabolite can cross the blood-brain and placental barriers. The compound significantly lowers concentrations of apolipoprotein-B-containing lipoproteins, primarily LDL cholesterol, moderately reduces plasma triglycerides, and slightly elevates HDL cholesterol levels. |
細胞研究 | Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2]. |
別名 | MK-803, Mevinolin |
分子量 | 404.54 |
分子式 | C24H36O5 |
CAS No. | 75330-75-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (111.24 mM)
Ethanol: 20.2 mg/mL (50 mM)), Heating is recommended.
5% DMSO+95% Saline: 2.03 mg/mL (5.01 mM, suspension)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Lovastatin 75330-75-5 Apoptosis Autophagy Metabolism HMG-CoA Reductase Ferroptosis MK 803 MK-803 Inhibitor MK803 Mevinolin HMG-CoA Reductase (HMGCR) inhibit inhibitor