Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 13,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 68,500 | |||
100 mg | 在庫あり | ¥ 103,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,000 |
説明 | MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM. |
ターゲット&IC50 | p53:10μM, WRN helicase:20 µM |
In vitro | MIRA-1 induces p53 transcriptional transactivation of p21, MDM2, and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro with an IC50 of 10μM[1]. |
別名 | p53 Activator VIII, 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione, (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate, NSC 19630, WRN Helicase Inhibitor |
分子量 | 183.16 |
分子式 | C8H9NO4 |
CAS No. | 72835-26-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL(109.19 mM)
Ethanol: 20 mg/mL(109.19 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MIRA-1 72835-26-8 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis p53 inhibit MDM-2/p53 p53 Activator VIII MIRA 1 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione NSC19630 Inhibitor H1299 SKOV (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate NSC 19630 WRN Helicase Inhibitor MIRA1 NSC-19630 Anticancer Saos-2 inhibitor