|
T4197 |
HZ-1157
|
HZ1157,DHFR-inhibitor |
HCV Protease
|
|
HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease. |
|
T9618 |
HeE1-2Tyr
|
|
SARS-CoV
|
|
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. It significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro. |
|
T23004 |
ML-SA1
|
Mucolipin synthetic agonist 1 |
Others
,
TRP/TRPV Channel
|
|
ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV... |
|
T11760 |
KIN101
|
3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene |
HCV Protease
,
Influenza Virus
,
RSV
,
Antifection
|
|
KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and R... |
|
T13397 |
ZINC03129319
|
|
Virus Protease
|
|
ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease. |
|
T64091 |
(-)-JNJ-A07
|
|
Others
|
|
(-)-JNJ-A07 is a selective and potent dengue virus (DENV) inhibitor (EC50:31 nM) with antiviral activity for the study of dengue virus infections. |
|
T8886 |
NITD-2
|
|
DNA/RNA Synthesis
|
|
NITD-2 is a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. Dengue virus (DENV) is the most prevalent mosquito- borne viral pathogen in hu... |
|
T16914 |
SP187
|
UV4,MON-DNJ |
Others
,
Virus Protease
,
Influenza Virus
|
|
SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses. |
|
T16325 |
NITD008
|
7-Deaza-2'-C-acetylene-adenosine |
Others
|
|
NITD008 (7-Deaza-2'-C-acetylene-adenosine) is a potent and selective adenosine nucleoside inhibitor.NITD008 is an adenosine nucleoside analog with broad-spectrum antiviral activity that inhibits dengue, animal cupripoxvi... |
|
T17190 |
U18666A
|
|
Others
,
HCV Protease
|
|
U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus. |
|
T16702 |
QL47
|
|
Virus Protease
,
BTK
|
|
QL47 is a host-targeted small molecule antiviral agent with antiviral activity against dengue and other RNA viruses.QL47 acts as an inhibitor of viral translation and a covalent inhibitor of BTK, and can be used in the s... |
|
T63143 |
DENV-IN-5
|
|
Virus Protease
,
HIV Protease
|
|
Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB. |
|
T38960 |
QL-X-138
|
|
Virus Protease
,
MNK
,
BTK
|
|
QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK.The IC 50 s of QL-X-138 against BTK, MNK1 and MNK2 kinases are 9.4 nM, 107.4 nM and 26 nM, respe... |
|
T76856 |
Andecaliximab
|
GS-5745 |
MMP
,
Virus Protease
|
|
Andecaliximab is a recombinant IgG4 monoclonal antibody targeting matrix metalloproteinase 9 (MMP9). Andecaliximab showed antifibrotic effects in a mouse model of idiopathic pulmonary fibrosis. Andecaliximab can be used ... |
|
T11281L |
FGI-106 tetrahydrochloride
|
|
Virus Protease
,
HCV Protease
,
Influenza Virus
,
HIV Protease
|
|
|
|
T38960L |
QL-X-138 HCl
|
QL-X-138 HCl（1469988-63-3 Free base） |
MNK
,
BTK
|
|
QL-X-138 HCl is a novel selective and highly potent BTK/MNK dual-kinase inhibitor with anticancer activity that binds covalently to BTK and noncovalently to MNK. QL-X-138 HCl inhibited BTK, MNK1, and MNK2 kinases. QL-X-1... |
|
T24432 |
MB21
|
MB-21,MB 21 |
|
|
MB21 is a dengue type 2 protease inhibitor that acts by inhibiting each one of the four serotypes of dengue viruses in infected cells in culture. |
|
T25171 |
BP13944
|
BP 13944,BP-13944 |
|
|
BP13944 is used as a potential dengue virus NS2B/NS3 protease inhibitor. |
|
T69649 |
NITD-688
|
|
|
|
NITD-688 is a pan-serotype inhibitor targeting the dengue virus NS4B protein, effective through oral administration. It holds potential in dengue virus (DENV) research applications. |
|
T27498 |
GSK983
|
GSK-983,GSK 983 |
|
|
GSK983, a potent broad-spectrum antiviral, blocks cell proliferation and dengue virus replication by inhibiting the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH). |
|
T39783 |
DENV-IN-2
|
|
|
|
DENV-IN-2 is a highly effective inhibitor of dengue viral replication with a potency indicated by an EC 50 of 0.016 nM. It exhibits significant activity against all four serotypes of the Dengue virus, with EC 50 values r... |
|
T69186 |
CP26
|
|
|
|
CP26 is a novel inhibitor of ER-to-cytosol protein dislocation, exhibiting anti-dengue and anti-Zika virus activity. |
|
T71748 |
RK-0404678
|
|
|
|
RK-0404678 is a novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities. |
|
T28860 |
ST-148
|
ST148 |
|
|
ST-148 is a potent inhibitor for Dengue virus capsid. ST-148-enhanced capsid protein self-interaction perturbs assembly and disassembly of DV nucleocapsids, probably by inducing structural rigidity. |
|
T19740 |
Narasin
|
Monteban,A28086A,A 28086A,A-28086A |
|
|
Narasin is a novel agent that inhibits dengue virus replication in vitro through non-cytotoxic mechanisms. It is used for the treatment of coccidiosis from a class of protozoa. It has been shown to foster the apoptosis o... |
|
T73311 |
DENV-IN-7
|
|
|
|
DENV-IN-7, a flavone analog, functions as an inhibitor of the dengue virus (DENV), demonstrating anti-dengue activity with an effective concentration (EC50) of 70 nM while exhibiting low toxicity against normal cells. |
|
T37870 |
Bz-Nle-Lys-Arg-Arg-AMC
|
|
|
|
Substrate for dengue virus NS2B-NS3 and yellow fever virus NS3 protease. The kcat/Km value of Bz-NleKRR-AMC for the dengue virus type 4 (DEN4) enzyme is > 800 fold higher than that of Boc-Gly-Arg-Arg-AMC, a widely used N... |
|
T82172 |
Hs-1
|
|
|
|
Hs-1, an antimicrobial peptide, exhibits 80% protection against the Dengue-2 virus [1]. |
|
T15554 |
IHVR-19029
|
|
Others
|
|
IHVR-19029 is an effective endoplasmic reticulum (ER) α-glucosidases I and II inhibitor (IC50: 0.48 μM for ER a-glucosidase I). IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as ... |
|
T27050 |
CM-10-18
|
CM-1018 |
|
|
CM-10-18 is a potent inhibitor of ER α-glucosidase. CM-10-18 demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever. CM-10-18 efficiently prote... |
|
T61703 |
GAK inhibitor 2
|
|
|
|
GAK inhibitor 2 (Compound 14g) is a highly potent inhibitor of cyclin G-associated kinase (GAK) with an IC 50 of 0.024 μM. It exhibits remarkable antiviral activity against dengue virus (DENV), with an EC 50 of 1.049 μM ... |
|
T38818 |
Golgicide A-2
|
Golgicide A-2,GCA-2 |
|
|
Golgicide A-2 (GCA-2), a derivative of Golgicide A (GCA), is the highly active enantiomer of GCA. It exhibits exceptional selectivity and efficiency in eradicating An. stephensi larvae, thus making it a valuable tool for... |
|
T64044 |
SP-471
|
|
|
|
SP-471 is a potent inhibitor of dengue virus (DENV) protease (IC50: 18 μM) and inhibits the inter- and intramolecular protease processes of DENV. |
|
T70954 |
SP-187 HCl
|
|
|
|
SP-187, also known as N-9-DNJ and UV-4B, is an alpha-Glucosidase inhibitor potentially for the treatment of dengue fever and influenza infection. Proline-producing strains of Serratia marcescens were more osmotolerant t... |
|
T11281 |
FGI-106
|
|
Others
|
|
FGI-106 is a potent, broad-spectrum inhibitor demonstrating activity against various viruses, including Ebola, Rift Valley Fever, and Dengue Fever, exhibiting EC50 values of 100 nM, 800 nM, and 400-900 nM, respectively. ... |
|
T37463 |
CAY10704
|
|
|
|
CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 μM). It displays good pharmacokinetics in m... |
|
T62932 |
NS2B/NS3-IN-2
|
|
|
|
NS2B/NS3-IN-2 is a potent, covalent inhibitor of dengue virus (DENV) NS2B/NS3 (IC50: 6.0 nM, Ki: 0.66 μM). NS2B/NS3-IN-2 significantly increases cell viability and is not cytotoxic. |
|
T25611 |
Lanatoside
|
Lantoside,ABC lanatoside complex |
|
|
Lanatoside is an FDA-approved cardiac glycoside that has been identified as a candidate anti-dengue compound. It has also been found to promote atherosclerosis. It also has anti-tumor activity, inhibiting the growth of c... |
|
T78562 |
FX-06
|
Fibrin-derived peptide Bβ15-42 |
|
|
FX-06 (Fibrin-derived peptide Bβ15-42) is a peptide derived from the fibrin Bbeta chain. It interacts with VE-cadherin to inhibit leukocyte transmigration and initiate VE-cadherin-mediated signaling pathways. This compou... |
|
T79334 |
Antiviral agent 36
|
|
DNA/RNA Synthesis
|
|
Antiviral agent 36 (compound 27), a potent inhibitor of both dengue (DENV) and Zika (ZIKV) viruses, demonstrates replication inhibition with EC50 values of 100 nM for ZIKV-FLR, 90 nM for ZIKV-HN16, 210 nM for DENV-2, and... |
|
T79141 |
Mosnodenvir
|
JNJ-1802 |
Virus Protease
|
|
Mosnodenvir (JNJ-1802), a pan-serotype dengue antiviral agent, exhibits picomolar to low nanomolar in vitro activity with a high barrier to resistance and is safe and well-tolerated in murine models [1] [2]. It functions... |
|
T78700 |
DENV-IN-10
|
|
|
|
DENV-IN-10 is a potent tetravalent inhibitor of the dengue virus, exhibiting half-maximal effective concentrations (EC50s) of 1.36, 0.87, 0.94, and 0.95 μM against the DENV-1, DENV-2, DENV-3, and DENV-4 serotypes, respec... |
|
T73420 |
SP-471P
|
|
|
|
SP-471P is a potent inhibitor of dengue virus (DENV) protease, exhibiting half-maximal effective concentrations (EC50) of 5.9 μM for DENV1, 1.4 μM for DENV2, 5.1 μM for DENV3, and 1.7 μM for DENV4, with a cytotoxic conce... |
|
T38309 |
LL-37 amide (trifluoroacetate salt)
|
|
|
|
LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D... |
