Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.
説明 | Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. |
ターゲット&IC50 | 5-HT2:25 nM(Ki), α1-adrenoceptor:77 nM(Ki) |
In vitro | Niaprazine demonstrates a low affinity for the vesicular monoamine transporter as well as D2, α2, β, H1, and mAch receptors. Notably, the (+)stereoisomer of Niaprazine shows a significantly higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, whereas it is poorly recognized by 5-HT1A and 5-HT1B binding sites[2]. |
In vivo | Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Niaprazine also produces a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA)[3]. Animal Model: Male Sprague-Dawley rats (150-200 g)[3] |
分子量 | 356.44 |
分子式 | C20H25FN4O |
CAS No. | 27367-90-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (280.55 mM)
You can also refer to dose conversion for different animals. 詳細
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Niaprazine 27367-90-4 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Adrenergic Receptor 5-HT Receptor 5-HIAA disorders sleep autistic inhibit 5-HT2 sedative Inhibitor H1-receptor inhibitor