Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 25,000 | |||
25 mg | 在庫あり | ¥ 52,500 | |||
50 mg | 在庫あり | ¥ 85,500 | |||
100 mg | 在庫あり | ¥ 137,000 | |||
500 mg | 在庫あり | ¥ 289,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation. |
In vitro | NSC59984 specifically restores p53 pathway signaling and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. NSC59984 also induces cell death in a panel of cancer cell lines bearing different p53 mutations with little or no genotoxicity in normal cells. [1] |
In vivo | In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. [1] |
細胞研究 | Cells are seeded at 5,000 cells per well on 96-well plates. Cells are mixed with an equal volume of CellTiter-Glo reagents, following the manufacturer's protocol, and bioluminescence imaging is measured using the IVIS imager.(Only for Reference) |
分子量 | 265.27 |
分子式 | C12H15N3O4 |
CAS No. | 803647-40-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 49 mg/mL (184.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 49 mg/mL (184.7 mM)
You can also refer to dose conversion for different animals. 詳細
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NSC59984 803647-40-7 Apoptosis p53 inhibit Inhibitor NSC-59984 MDM-2/p53 NSC 59984 inhibitor