Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 15,000 | |||
25 mg | 在庫あり | ¥ 26,500 | |||
50 mg | 在庫あり | ¥ 43,500 | |||
100 mg | 在庫あり | ¥ 65,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL. |
ターゲット&IC50 | CE2 (human):132.8 μM (IC50), CE1 (human):2.64 μM (IC50) |
In vitro | The alkenylbenzene methyleugenol occurs naturally in a variety of spices and herbs, including basil, and their essential oils. At high dose levels methyleugenol induces hepatocarcinogenicity in rodents following bioactivation to 1'-sulfooxymethyleugenol which forms DNA adducts. METHODS AND RESULTS: This study investigated whether the inhibitory effect of the basil flavonoid Nevadensin on sulfotransferase (SULT)-mediated bioactivation of methyleugenol observed in vitro would also be reflected in a reduction of DNA adduct formation and a reduction in an early marker for liver carcinogenesis in an 8-week rat study. Co-exposure to methyleugenol and Nevadensin orally resulted in a significant inhibition of liver methyleugenol DNA adduct formation and in inhibition of hepatocellular altered foci induction, representing indicators for initiation of neoplasia. CONCLUSIONS: These results suggest that tumor formation could be lower in rodent bioassays when methyleugenol would be dosed in a matrix containing SULT inhibitors such as Nevadensin compared to experiments using the pure methyleugenol. |
植物由来 |
別名 | Pedunculin |
分子量 | 344.32 |
分子式 | C18H16O7 |
CAS No. | 10176-66-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 14.71 mg/mL (42.72 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Nevadensin 10176-66-6 Microbiology/Virology Anti-infection Antibacterial pharmacological selective Pedunculin Inhibitor flavonoid effect Bacterial natural inhibit inhibition inhibitor