|
T12597 |
5-HT2 antagonist 1
|
|
5-HT Receptor
|
|
5-HT2 antagonist 1 is a potent 5-HT2 receptor antagonist, has weak α1 adrenoceptor blocking activity. |
|
T36949 |
Niaprazine
|
|
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2].
Niaprazine exhibits a low aff... |
|
T15270 |
Fananserin
|
RP 62203 |
Dopamine Receptor
,
5-HT Receptor
|
|
Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopamine D4 receptor (Ki: 2.93 nM for the human dopamine D4 recep... |
|
T0137 |
Mirtazapine
|
6-Azamianserin,Org3770 |
Dopamine Receptor
,
5-HT Receptor
,
Opioid Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h... |
|
T79804 |
5-HT2 agonist-1
|
|
5-HT Receptor
|
|
Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively. The free base form of this compound is utilized in research pertaini... |
|
T14968 |
Cinanserin hydrochloride
|
SQ 10643 |
Influenza Virus
,
5-HT Receptor
|
|
Cinanserin hydrochloride (SQ 10643) is a high affinity antagonist of the 5-HT2 receptor (Ki: 41 nM) and a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus. |
|
T4369 |
SCH-23390 hydrochloride
|
R-(+)-SCH23390 hydrochloride |
Potassium Channel
,
Dopamine Receptor
,
5-HT Receptor
|
|
SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM). |
|
T79805 |
5-HT2 agonist-1 free base
|
|
5-HT Receptor
|
|
Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively. It is utilized in research pertaining to depression... |
|
T1567 |
Olanzapine
|
LY170053 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
|
|
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. |
|
T22904 |
L-745870 trihydrochloride
|
L-745,870 trihydrochloride |
Dopamine Receptor
,
Sigma receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist. |
|
T12865 |
SCH-23390 maleate
|
R-(+)-SCH-23390 maleate |
Potassium Channel
,
Dopamine Receptor
,
5-HT Receptor
|
|
|
|
T5389 |
Volinanserin
|
M 100907,MDL100907 |
5-HT Receptor
|
|
Volinanserin (MDL100907) (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma recepto... |
|
T22029 |
AL 34662
|
|
5-HT Receptor
,
Adrenergic Receptor
|
|
AL 34662 is a selective and potent 5-HT2A receptor agonist with IC50s of 0.77 nM and 1.5 nM for rat and human 5-HT2 receptors, respectively.AL 34662 is also a low affinity α-1D adrenergic agonist, with an EC50 of 0.4 μM.... |
|
T23382 |
Spiroxatrine
|
R 5188 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Spiroxatrine (R 5188) is a selective and potent 5-HT1α and α2-adrenergic dual antagonist with sedative activity and inhibitory effects on 5-HT1α, 5-HT1 β, 5-HT2, and dopamine receptors.Spiroxatrine may be used in the stu... |
|
T16759 |
Ritanserin
|
R 55667 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Ritanserin (R 55667) is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM), less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors. |
|
T8702 |
SKF-83566
|
|
Dopamine Receptor
,
5-HT Receptor
,
AChR
|
|
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM |
|
T22959 |
M-Chlorophenylbiguanide hydrochloride
|
1-(3-Chlorophenyl)biguanidehydrochloride |
5-HT Receptor
|
|
5-HT3 receptor agonist |
|
T2599 |
Pirenperone
|
|
5-HT Receptor
|
|
Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action. |
|
T68142 |
Serazapine
|
|
5-HT Receptor
|
|
Serazapine is a highly specific serotonin (5-HT2) binding inhibitor with anxiolytic activity for the treatment of anxiety disorders. |
|
T22947 |
LY266097 hydrochloride
|
LY 266097 hydrochloride |
5-HT Receptor
|
|
LY266097 hydrochloride (LY 266097 hydrochloride) is an antagonist of 5-HT2 with pKis of 7.7, 9.8, and 7.6 for human 5-HT2A, 5-HT2B, and 5-HT2C and can be used in studies about depression. |
|
T2190 |
Methiothepin mesylate
|
Ro 8-6837 mesylate,Metitepine mesylate |
Dopamine Receptor
,
5-HT Receptor
|
|
Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic. |
|
T24885 |
Tiospirone
|
BMY 13859-1 |
Dopamine Receptor
,
5-HT Receptor
|
|
Tiospirone (BMY 13859-1 free base) is a 5-HT2 receptor antagonist and dopamine blocker that inhibits D2, 5-HT1a, 5-HT7, and sigma receptors.Tiospirone is used in the study of neurological disorders such as schizophrenia. |
|
T22871 |
Ipsapirone
|
|
5-HT Receptor
|
|
Ipsapirone is a partial agonist of 5-HT1A receptor and produces an inhibitory effect on 5-HT2 and the α1-adrenergic function at high doses. |
|
T22689 |
CP94253 hydrochloride
|
CP 94253 hydrochloride |
Others
,
5-HT Receptor
|
|
CP94253 hydrochloride (CP 94253 hydrochloride) is a potent, selective and centrally active agonist of 5-HT1B receptor with Ki of 2 nM. The Kis are 89, 49, 860, and 1600 nM for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors, ... |
|
T0351 |
Risperidone
|
Risperidal,R 64 766 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
P-gp
|
|
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent. |
|
T3497 |
Ocaperidone
|
Ocaperidona,R79598 |
Dopamine Receptor
,
5-HT Receptor
|
|
Ocaperidona (Ocaperidone (Ocaperidona)), a very high affinity dopamine D2 antagonist. |
|
T68080 |
Gevotroline
|
|
5-HT Receptor
|
|
Gevotroline, a chemical in palm wine that can be used to treat psychosis, is a 5-HT2 receptor antagonist that can be used to study behavioral disorders. |
|
T12596 |
(4E)-SUN9221
|
|
5-HT Receptor
,
Adrenergic Receptor
|
|
|
|
T10872L |
CP 96021
|
|
5-HT Receptor
|
|
CP 96021 is a group of 5-HT1 receptors and 5-HT2 receptors antagonists that have anti-inflammatory properties and are non-non-self anti-ulcer compounds for the treatment of gastrointestinal tract and respiratory asthma. |
|
T12632L |
(S)-Mirtazapine
|
(S)-6-Azamianserin,(S)-Org3770 |
5-HT Receptor
|
|
(S)-Mirtazapine ((S)-Org3770) is the S(+)-enantiomer of Mirtazapine. (S)-Mirtazapine is a selective 5-HT2 receptor antagonist with pro-nociceptive effects and is often used in combination with the R(-)-enantiomer of Mirt... |
|
T21385 |
Cinitapride
|
Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove |
5-HT Receptor
|
|
Cinitapride (Blaston) is a gastroprokinetic agent. It slows the actions of the muscles to reduce the symptoms of conditions such as acid reflux, delayed gastric emptying, and ulcer dyspepsia. Cinitapride acts as an antag... |
|
T30098 |
Aplindore Fumarate
|
Aplindore,DAB-452 Fumarate,DAB-452 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-H... |
|
T28167 |
NGB 2904
|
NGB2904 HCl,NGB-2904,NGB2904 |
Others
,
Dopamine Receptor
,
5-HT Receptor
|
|
NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antag... |
|
T22987 |
MK 212 hydrochloride
|
|
5-HT Receptor
|
|
MK 212 hydrochloride is a 5-HT2C receptor agonist |
|
T0225 |
Pizotifen Malate
|
Pizotyline (malate),BC-105 (malate),BC-105 |
5-HT Receptor
|
|
Pizotifen Malate (BC-105 malate), a highly selective 5-HT receptor blocking agent, is a drug based on benzocycloheptane. |
|
T1735 |
Lurasidone hydrochloride
|
Lurasidone HCl,SM-13496 (Hydrochloride),SM-13496 |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
|
|
Lurasidone hydrochloride (Lurasidone HCl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antag... |
|
T0074L |
Chlorprothixene hydrochloride
|
NSC 78193,Minithixen,Truxal hydrochloride,NSC 56379,NSC 169899,Minithixen hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Antibacterial
,
AChR
,
Histamine Receptor
|
|
Chlorprothixene hydrochloride (Truxal hydrochloride) brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene hydrochloride s a typical an... |
|
T4978 |
Sarpogrelate hydrochloride
|
MCI-9042 |
5-HT Receptor
|
|
Sarpogrelate hydrochloride (MCI-9042) , a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is a drug which acts as an antagonist at ... |
|
T0162 |
Quetiapine
|
ICI204636,Quetiapin |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
|
|
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago... |
|
T1539 |
Iloperidone
|
HP 873 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Iloperidone (HP 873) is an atypical antipsychotic agent that is used for treatment of schizophrenia. |
|
T2546 |
Pimozide
|
R6238 |
Potassium Channel
,
Dopamine Receptor
,
Adrenergic Receptor
,
STAT
|
|
Pimozide (R6238) is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby... |
|
T1081 |
Naftidrofuryl oxalate
|
Nafronyl oxalate,Nafronyl oxalate salt |
5-HT Receptor
|
|
Naftidrofuryl oxalate (Nafronyl oxalate) is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It may also be an ant... |
|
T1442 |
Pizotifen
|
Pizotyline,BC-105 |
5-HT Receptor
|
|
Pizotifen (Pizotyline) is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appetite-stimulating properties. Pizotifen hydroch... |
|
T6814 |
Cyproheptadine hydrochloride
|
Periactin hydrochloride,Anarexol,Cyproheptadine HCl,Nuran |
5-HT Receptor
|
|
Cyproheptadine hydrochloride (Periactin hydrochloride) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist. |
|
T11799 |
L-745870 hydrochloride
|
|
Dopamine Receptor
|
|
L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM, and considerably weaker D2 recept... |
|
T11217 |
Eplivanserin
|
SR-46349 |
5-HT Receptor
|
|
|
|
T0174 |
Cyproheptadine hydrochloride sesquihydrate
|
Peritol,Periactin hydrochloride,Cyproheptadine hydrochloride |
5-HT Receptor
,
Histone Methyltransferase
,
Histamine Receptor
|
|
Cyproheptadine hydrochloride sesquihydrate (Peritol), an antihistamine, is an antagonist of serotonin and histamine2. |
|
T1412 |
Loxapine succinate
|
Daxolin,Loxapac,Cloxazepin,Loxapine succinate salt |
Dopamine Receptor
,
5-HT Receptor
|
|
Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia. |
|
T23246 |
Ro 60-0175 fumarate
|
|
Others
|
|
5-HT2 receptor agonist |
|
T23219 |
R-96544 hydrochloride
|
|
Others
|
|
5-HT2 receptor antagonist |
