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T36949 |
Niaprazine
|
|
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2].
Niaprazine exhibits a low aff... |
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T3563 |
Lvguidingan
|
|
Others
|
|
Lvguidingan is an Anticonvulsant agent. |
|
T8887 |
2'MeO6MF
|
|
GABA Receptor
|
|
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response... |
|
T6464 |
Detomidine hydrochloride
|
MPV-253 AII,Domosedan,Detomidine HCl |
Adrenergic Receptor
|
|
Detomidine hydrochloride (MPV-253 AII) produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors. |
|
T7699 |
AZD7325
|
AZD-7325 |
P450
,
GABA Receptor
|
|
AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator. |
|
T14983 |
Clomethiazole
|
Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE |
P450
,
GABA Receptor
|
|
Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: C... |
|
T0370 |
Pheniramine maleate
|
Daneral,Inhiston,Trimetose |
5-HT Receptor
,
Histamine Receptor
|
|
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re... |
|
T0205 |
Brompheniramine maleate
|
Dimotane,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane |
5-HT Receptor
,
Histamine Receptor
|
|
Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors. |
|
T23445 |
Anxiolytic/nonsedative agent-1
|
TCS 1205 |
GABA Receptor
|
|
Anxiolytic/nonsedative agent-1 (TCS 1205) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α... |
|
T11506 |
Guaiapate
|
Mg 5454,Klamar |
Others
|
|
Guaiapate has an antitussive and sedative effect. |
|
T30248 |
AZD 3043
|
AZD-3043,THRX 918661,AZD3043 |
|
|
AZD 3043 is a propofol derivative which acts as a sedative-hypnotic agent. |
|
T31724 |
Etoxybamide
|
|
Others
|
|
Etoxybamide is a drug candidate for sedative (hypnotic). |
|
T28887 |
Suriclone
|
RP-31264,RP31264,RP 31264 |
GABA Receptor
|
|
Suriclone (RP 31264) is a selective cyclic pyrrolidone analog with sedative and anxiolytic activity, but not significant sedative effects.Suriclone shows its effects by modulating GABA-A receptors. |
|
T14314 |
Apronal
|
Apronalide,Allylisopropylacetylurea |
Others
|
|
Apronal (Apronalide) has the hypnotic and sedative capacity and can be used for studies about neuropsychiatry disorders. |
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T83647 |
(Z)-Tenilapine
|
|
Others
|
|
(Z)-Tenilapine is trans-Tenilapine, cis-Tenilapine has sedative activity. |
|
T28303 |
Pazinaclone
|
A-77000,DN-2327,DN2327,DN 2327,A 77000,A77000 |
GABA Receptor
|
|
Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity. |
|
T0227 |
Bromisoval
|
2-Bromo-N-carbamoyl-3-methylbutanamide,Isobromyl,BRN 1773255,Bromovalerylurea,Bromaral |
Others
|
|
Bromisoval (Isobromyl) is a mild hypnotic and sedative with potential toxicity. |
|
T32845 |
Lofendazam
|
Bu 1014 |
|
|
Lofendazam (Bu 1014) is a benzodiazepine derivative that has sedative and anxiolytic effects. |
|
T29096L |
Vapitadine
|
R 129160 |
Histamine Receptor
|
|
Vapitadine is a non-sedative antihistamine compound that relieves itching caused by atopic dermatitis. |
|
T0240 |
Trimetozine
|
Sedoxazine,Trioxazin |
Others
|
|
Trimetozine (Sedoxazine) is a sedative that has been marketed in Europe since 1959. It has mild tranquilizing effects and has been used to treat anxiety. |
|
T10796 |
Chlormethiazole hydrochloride
|
Clomethiazole hydrochloride |
Others
|
|
Chlormethiazole hydrochloride is an anticonvulsant and sedative. It also has neuroprotective. |
|
T0147 |
Clemastine fumarate
|
HS-592 (fumarate),Meclastine fumarate,Meclastine (fumarate) |
Autophagy
,
Histamine Receptor
|
|
Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
|
T10002 |
(E)-Crotylbarbital
|
Kalypnon |
Others
|
|
(E)-Crotylbarbital (Kalypnon), an isomer of Crotylbarbital, is a barbiturate derivative that has sedative, hypnotic, and anticonvulsant effects. (E)-Crotylbarbital can be used in studies to promote mental stability and s... |
|
T2222 |
Carbinoxamine Maleate Salt
|
Lergefin,CarbinoxaMine Maleate |
Histamine Receptor
|
|
Carbinoxamine Maleate Salt (Lergefin) is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties. |
|
T1269 |
Tripelennamine hydrochloride
|
Pyribenzamine hydrochloride,Tripelennamine HCl,Pyribenzamine HCl |
Histamine Receptor
|
|
Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. |
|
T8971 |
Imidazenil
|
|
GABA Receptor
|
|
Imidazenil is an modulator of GABA-A that blocks the sedative effects without lowering the convulsion threshold. |
|
T21011 |
Buspirone
|
Buspirone free base,Ansial |
5-HT Receptor
|
|
Buspirone (Buspirone free base) is an azaspiro compound which has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. |
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T1864 |
Fabomotizole
|
Obenoxazine,CM346 |
Others
|
|
Fabomotizole (Obenoxazine) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. |
|
T4275 |
Fluanisone
|
Sedalande,Haloanison |
Others
|
|
Fluanisone (Haloanison) is a butyrophenone derivative with sedative properties. It is a typical antipsychotic and is used in the treatment of schizophrenia. |
|
T26600 |
Alpidem
|
Ananxyl |
GABA Receptor
|
|
Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family. Alpidem does not produce sedative effects at normal doses, and is instead used specifically for the treatment of anxiety. Alpidem has nanomolar bin... |
|
T6398 |
Azaperone
|
R-1929,Fluoperidol,Stresnil,NSC 170976,Suicalm |
Others
,
Dopamine Receptor
|
|
Azaperone (Fluoperidol) is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. |
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T68047 |
Clopipazan
|
|
Others
|
|
Clopipazan is an antipsychotic and antidepressant compound.Clopipazan has sedative and anxiolytic activity, possibly due to selective GABergic blockade of certain interneurons. |
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T3282 |
Alimemazine hemitartrate
|
Alimemazine Tartrate,Methylpromazine Tartrate,Trimeprazine tartrate,Trimeprazine hemitartrate |
Others
|
|
Alimemazine hemitartrate (Trimeprazine hemitartrate) is aphenothiazine derivative that is used as an antipruritic. It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. |
|
T23382 |
Spiroxatrine
|
R 5188 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Spiroxatrine (R 5188) is a selective and potent 5-HT1α and α2-adrenergic dual antagonist with sedative activity and inhibitory effects on 5-HT1α, 5-HT1 β, 5-HT2, and dopamine receptors.Spiroxatrine may be used in the stu... |
|
TNU0429 |
N6-(2-Hydroxyethyl)adenosine
|
|
Calcium Channel
|
|
N6-(2-Hydroxyethyl)adenosine is a Ca2+ antagonist and anti-inflammatory agent that is associated with the control of cerebral and coronary circulation and is thought to possess sedative activity. |
|
T21419 |
Diphenhydramine
|
Debendrin,PM 255,PM255,Dabylen,Syntedril,PM-255 |
Histamine Receptor
|
|
Diphenhydramine (Syntedril), a first-generation antihistamine possessing antiemetic, antitussive, anticholinergic, and sedative properties, is mainly used in the treatment of allergies. Diphenhydramine is also used in th... |
|
T0901 |
Chlorobutanol
|
Chlortran,Chloretone,YM-57158,Chlorbutol,Chloreton |
Antibacterial
,
Antibiotic
,
Antifungal
|
|
Chlorobutanol (Chlortran) is a chemical preservative, sedative hypnotic and weak local anaesthetic. It has Antibacterial and Antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lend... |
|
T1249 |
Beclamide
|
N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon |
Others
|
|
Beclamide (Chlorakon) (N-benzyl-B-chloropropionamide) is a drug that possesses anticonvulsant activity. It is no longer used. It has been used as a sedative and as an anticonvulsant. It was studied in the 1950s for its a... |
|
T5954 |
Methyldopa hydrate
|
Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate |
Dopamine Receptor
,
Adrenergic Receptor
|
|
Methyldopa hydrate (MK-351 hydrate) is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympathetic nervous system, decreases production of dopamine, ... |
|
T0053 |
Hydroxyzine Pamoate
|
Hydroxyzine embonate,Bobsule,Equipose |
Histamine Receptor
|
|
Hydroxyzine Pamoate (Bobsule) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does ca... |
|
T12489L |
Pimethixene maleate
|
Pimetixene maleate |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... |
|
T50048 |
4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one
|
|
Others
|
|
4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one is a benzodiazepine derivative. It is an orthosteric modulator of the GABAA receptor and selectively binds to the benzodiazepine site of the GABAA receptor. It h... |
|
T1266 |
Terfenadine
|
(±)-Terfenadine,MDL-991 |
Apoptosis
,
Potassium Channel
,
5-HT Receptor
,
Caspase
,
Na+/Ca2+ Exchanger
,
HER
,
AChR
,
Histamine Receptor
|
|
Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. |
|
T4993 |
Afloqualone
|
HQ-495 |
GABA Receptor
|
|
Afloqualone (HQ-495) is a agonist of GABA Receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. It has sedative and muscle-relaxant effects, resulting from its agonist activity ... |
|
T1278 |
Astemizole
|
Laridal,Histaminos,Paralergin |
Potassium Channel
,
Histamine Receptor
|
|
Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to re... |
|
T0939 |
Phenytoin
|
Diphenylhydantoin,5,5-Diphenylhydantoin |
Virus Protease
,
Sodium Channel
|
|
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor... |
|
T4688 |
Pipequaline hydrochloride
|
PK-8165 hydrochloride |
GABA Receptor
|
|
Pipequaline hydrochloride (PK-8165 hydrochloride) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely re... |
|
T2200 |
Hydroxyzine dihydrochloride
|
Hydroxyzine 2HCl |
Histamine Receptor
|
|
Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIR... |
|
T1442 |
Pizotifen
|
Pizotyline,BC-105 |
5-HT Receptor
|
|
Pizotifen (Pizotyline) is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appetite-stimulating properties. Pizotifen hydroch... |
|
T1115 |
Doxylamine succinate
|
Decapryn |
Histamine Receptor
|
|
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ... |
