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T7107 |
δ-Sleep Inducing Peptide
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DSIP,Delta-Sleep Inducing Peptide |
Antioxidant
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δ-Sleep Inducing Peptide (DSIP) is a neuropeptide, with antioxidant and anxiolytic properties. |
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T78005 |
δ-Sleep Inducing Peptide acetate
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Delta-Sleep Inducing Peptide acetate |
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δ-Sleep Inducing Peptide acetate, a neuropeptide, exhibits antioxidant and anxiolytic properties [1] [2]. |
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T82587 |
Delta (Phospho) Sleep Inducing Peptide
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DSIP-P |
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Delta (Phospho) Sleep Inducing Peptide (DSIP-P), a peptide that promotes sustained sleep, elicits alterations in circadian locomotor activity in rats [1] [2] [3]. |
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T36949 |
Niaprazine
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5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
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Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2].
Niaprazine exhibits a low aff... |
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T7694 |
6-fluoro-DL-Tryptophan
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5-HT Receptor
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6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis. |
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T7413 |
JNJ-5207852
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Histamine Receptor
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JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor. |
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T16421 |
P-MPPI hydrochloride
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5-HT Receptor
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p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. |
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T8944 |
TTA-A2
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Calcium Channel
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TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ... |
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T8822 |
JNJ-5207852 dihydrochloride
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Histamine Receptor
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JNJ-5207852 dihydrochloride is a novel, non-imidazole histamine H3 receptor antagonist with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor. |
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T12877L |
Seltorexant
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JNJ-42847922 |
OX Receptor
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Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a... |
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T3722 |
MK-1064
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Urokinase inhibitor 1,MK 1064 |
OX Receptor
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MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA). |
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T63736 |
Bafrekalant
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Others
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Bafrekalant is a diazabicyclo-substituted imidazo[1,2-a]pyrimidine derivative that can be used to study sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring. |
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T14974 |
Citenamide
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Cytenamide,AY-15613 |
Others
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Citenamide (AY-15613) has anticancer and anticonvulsant activity and is used in the study of neurological disorders because of its sleep-promoting properties. |
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T24421 |
LY-2624803
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DB-7,LY2624803,HY-10275,LY 2624803 |
5-HT Receptor
,
Histamine Receptor
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LY-2624803 is a 5-HT2A receptor antagonist and histamine receptor inverse agonist that can be used to improve slow wave sleep. |
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T33824 |
Orotirelin
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CG 3509,Orotireline |
Others
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Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia. |
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T26559 |
ACT-462206
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OX Receptor
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ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety. |
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T30188L1 |
(Iso)-Atagabalin HCl
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(Iso)-Atagabalin HCl((Iso)-223445-75-8) |
Others
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(Iso)-Atagabalin HCl(isomer-Atagabalin HCl) is an alpha -2- delta ligand that can be used to treat non-restorative sleep. |
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T67966 |
Triflubazam
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Triflubazam has a wide range of biological activities that can affect sleep and can be used to treat anxiety syndromes and psychological disorders. |
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T3495 |
Tasimelteon
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VEC-162,BMS-214778 |
Melatonin Receptor
,
MT Receptor
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Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals. |
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T10002 |
(E)-Crotylbarbital
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Kalypnon |
Others
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(E)-Crotylbarbital (Kalypnon), an isomer of Crotylbarbital, is a barbiturate derivative that has sedative, hypnotic, and anticonvulsant effects. (E)-Crotylbarbital can be used in studies to promote mental stability and s... |
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TQ0023 |
Lorediplon
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GABA Receptor
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Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep. |
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T37979 |
N-Desmethyl Pimavanserin
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AC-279 |
5-HT Receptor
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N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin, a 5-HT2A receptor inverse agonist, which is used in the treatment of sleep disorders such as insomnia. |
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T30188L |
Atagabalin HCl
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PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base） |
Calcium Channel
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Atagabalin HCl is a novel voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) ligand that affects slow-wave sleep and can be used to treat insomnia. |
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T6552 |
Istradefylline
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KW-6002 |
Adenosine Receptor
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Istradefylline (KW-6002)(Ki of 2.2 nM) is a selective adenosine A2A receptor (A2AR) antagonist, which is under development in Phase 3 trails. It has been used in trials studying the treatment and basic science of Drug Ab... |
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T34081 |
Piromelatine
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NEU-P-11,NEU-P 11,NEU-P11 |
P2X Receptor
,
5-HT Receptor
,
MT Receptor
,
Sodium Channel
,
TRP/TRPV Channel
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Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... |
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T76867 |
Ravulizumab
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ALXN1210 |
Complement System
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Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity to block complement activation. Ravulizumab can be used fo... |
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T22530 |
6-Chloromelatonin
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Melatonin Receptor
,
Dopamine Receptor
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6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]... |
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T30629 |
Butoctamide semisuccinate
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M 2H,Butoctamide hydrogen succinate,M-2H,M2H |
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Butoctamide semisuccinate enhances REM sleep in chronically prepared cats. |
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T68685 |
Mioflazine hydrochloride
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Mioflazine hydrochloride is a nucleoside transport inhibitor that acts on adenosine to improve sleep. |
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T68603 |
Mioflazine hydrochloride anhydrous
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Mioflazine hydrochloride anhydrous is a nucleoside transport inhibitor that acts on adenosine to improve sleep. |
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T37664 |
Emideltide (acetate)
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Emideltide, also known as delta sleep-inducing peptide (DSIP), is a synthetic nonapeptide sedative.1 |
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T16076 |
Mioflazine
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Others
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Mioflazine suppresses nucleoside uptake. Mioflazine is an orally active nucleoside transport inhibitor. It has the potential for sleep disorders treatment. |
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T80392 |
NEMURI
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NEMURI is a sleep-promoting antimicrobial peptide [1]. |
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T27430 |
GR 196429
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GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429 |
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GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice. |
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T36591 |
ABD459
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ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). It inhibits food consumption in nonfasted mice without affecting motor activity. ABD459 reduces active food seeking for 5-6 hours ... |
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T34752 |
Samelisant dihydrochloride
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SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl |
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Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, ob... |
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T68327 |
Dexnafenodone Free Base
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Dexnafenodone Free Base is a potent inhibitor of noradrenaline, and to a lesser degree of serotonin reuptake, induced changes in the pattern of sleep which are comparable to those of non‐sedating tricyclic antidepressant... |
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T38143 |
Elaidamide
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Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and hu... |
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TP1188 |
Cortistatin 14, human, rat
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CST-14, human, rat |
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Cortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus. |
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T39004 |
Vornorexant
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ORN-0829,TS-142 |
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Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC 50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia tr... |
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TP1550 |
Orexin A (human, rat, mouse) (TFA)
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Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and o... |
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T17095 |
TIK-301
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PD-6735,LY-156735 |
5-HT Receptor
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TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor an... |
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T71423 |
AZD5213
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AZD5213 is a selective, competitive antagonist of the human H3 receptor, exhibiting a pK i of 9.3 against hH3R. It is utilized in the research of sleep and cognitive regulation. |
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T71209 |
CGS 12066A
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CGS 12066A is a drug which acts as a potent and selective agonist for the 5-HT1B receptor with lower affinity for the three 5-HT₂ receptor subtypes. It is used for studying the role of the 5-HT1B receptor in various proc... |
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T38257 |
PGDM
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Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smoot... |
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T38172 |
RO 5263397 hydrochloride
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Potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhib... |
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T60445 |
Desipramine
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Desipramine is a tricyclic psychotic compound with antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activ... |
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T75970 |
Melanin Concentrating Hormone, salmon TFA
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Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide discovered in teleost fish's pituitary gland, involved in controlling food intake, energy balance, sleep states, and cardiovasc... |
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T38341 |
11(Z),14(Z)-Eicosadienoic Acid methyl ester
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11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid , a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inos... |
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T70035 |
Tasimelteon-d5
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Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ... |
