Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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100 mg | 在庫あり | ¥ 9,500 | |||
1 g | 在庫あり | ¥ 12,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity. |
ターゲット&IC50 | H2 receptor:0.9 nM, AChE:6.7 μM |
In vitro | In rats, Nizatidine exhibits its maximum inhibitory effect on gastric acid secretion one hour after administration, with an EC50 value of 1.383 μMol/kg. Intravenous administration of Nizatidine (0.3-3 mg/kg) not only enhances gastrointestinal motility but also suppresses gastric acid secretion, achieving 50% of the maximal effect at a dose of 2.94 mg/kg and 90% at 19.6 mg/kg for rats. |
In vivo | Nizatidine is a reversible, non-competitive inhibitor of acetylcholinesterase (IC50=6.7 μM, Ki=7.4 μM) and a selective antagonist of the histamine H2 receptor, effectively inhibiting gastric acid secretion (IC50=0.9 nM). |
別名 | Axid, Acinon, Zanizal |
分子量 | 331.46 |
分子式 | C12H21N5O2S2 |
CAS No. | 76963-41-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (181.02 mM)
H2O: 26 mg/mL (78.4 mM)
Ethanol: 15 mg/mL (45.3 mM)
You can also refer to dose conversion for different animals. 詳細
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Nizatidine 76963-41-2 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor AChE cancer gastroesophageal reflux disease inhibit intestines ulcers Axid hcc stomach Acinon Inhibitor erosive esophagitis Zanizal acid GERD inhibitor