Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
説明 | OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain. |
ターゲット&IC50 | BRPF1B:100 nM(Kd), BRPF2:500 nM(Kd) |
In vitro | As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity. [1] |
分子量 | 440.31 |
分子式 | C17H18BrN3O4S |
CAS No. | 919973-83-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8.8 mg/mL (20 mM)
You can also refer to dose conversion for different animals. 詳細
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OF-1 919973-83-4 Chromatin/Epigenetic Epigenetic Reader Domain Inhibitor inhibit OF1 OF 1 inhibitor