Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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50 mg | 在庫あり | ¥ 11,500 | |||
100 mg | 在庫あり | ¥ 20,500 | |||
500 mg | 在庫あり | ¥ 58,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone. |
In vitro | Paliperidone significantly increases the intracellular accumulation of Rh123 and DOX in a concentration-dependent manner. [1] Paliperidone works finely at low concentrations (10 and 50 μM) against Aβ(25-35) and MPP(+) and solely protects SH-SY5Y from hydrogen peroxide. Paliperidone (100 μM) completely diminishes cell reduction induced by different stressors, regardless of their dosages. Paliperidone is demonstrated with higher oxidative stress-scavenging properties than other APDs in several aspects, such as generated bulk glutathione, low HNE, and protein carbonyl productions. [2] Paliperidone enhances dopamine toxicity at the highest dose and is the only AP that significantly increases cell viability (8.1%) compared with cells treated with dopamine alone. [3] |
別名 | 9-hydroxyrisperidone |
分子量 | 426.48 |
分子式 | C23H27FN4O3 |
CAS No. | 144598-75-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.3 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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Paliperidone 144598-75-4 GPCR/G Protein Immunology/Inflammation Neuroscience Adrenergic Receptor Histamine Receptor 5-HT Receptor Dopamine Receptor schizophrenia antipsychotic atypical inhibit 5-hydroxytryptamine Receptor Beta Receptor metabolite Inhibitor Serotonin Receptor 9-hydroxyrisperidone inhibitor