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T74798 |
Antipsychotic agent-2
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|
|
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Antipsychotic agent-2 (Compound 11) is a potent antipsychotic with high affinities for 5-HT 1A, 5-HT 2A, 5-HT 2C, D 2, and H 1 receptors, exhibiting K i values of 56.6, 66.7, 552, 596, and 1140 nM, respectively. It also ... |
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T9827 |
Carfenazine
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Dopamine Receptor
|
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carfenazine targets the Dopamine receptor and is used for schizophrenia research. |
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T22641 |
CDPPB
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|
GluR
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CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5). |
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T10232 |
Acetophenazine dimaleate
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|
Dopamine Receptor
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Acetophenazine dimaleate is an antipsychotic agent, effective in anxious depression. Acetophenazine dimaleate primarily targets the dopamine D2 receptor. |
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T9070 |
ASP2905
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ASP-2905 |
Potassium Channel
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ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsychotic activities |
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T19680 |
Zotepine
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|
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
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Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second... |
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T6022 |
LY404039
|
pomaglumetad |
Glucocorticoid Receptor
,
GluR
|
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LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM). |
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T14830 |
Bromperidol
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R-11333 |
5-HT Receptor
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Bromperidol (R-11333) is a butyrophenone derivative and it is a potent and long-acting neuroleptic. Which is used as an antipsychotic in the treatment of schizophrenia. |
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T2053 |
ADX-47273
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BA 94673139 |
GluR
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ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM). |
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T16472 |
Pericyazine
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Propericiazine,RP 8909 |
Dopamine Receptor
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Pericyazine (Propericiazine) is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term management of severe anxiety states and psych... |
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T8357 |
SB-200646
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5-HT Receptor
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SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor |
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T24055 |
FAUC 213
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FAUC213,FAUC-213 |
Dopamine Receptor
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FAUC 213 is a selective full antagonist of the dopamine D4 receptor. |
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T0766 |
Promazine hydrochloride
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Romtiazin hydrochloride,Sinophenin hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
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Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as ... |
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T1539 |
Iloperidone
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HP 873 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
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Iloperidone (HP 873) is an atypical antipsychotic agent that is used for treatment of schizophrenia. |
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T4576 |
Perospirone
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Lullan |
Dopamine Receptor
,
5-HT Receptor
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Perospirone (Lullan) is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. |
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T10871 |
CP-809101 hydrochloride
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5-HT Receptor
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CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). |
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T4195 |
Betahistine
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PT 9 base,Vasomotal,Serc base |
Histamine Receptor
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Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahisti... |
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T1566 |
Aripiprazole
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OPC-14597 |
5-HT Receptor
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Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a... |
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T25487 |
Haloperidol decanoate
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KD 16,KD-136,KD 136,Neoperidole,Haldol |
Others
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Haloperidol decanoate (KD 16) is a typical antipsychotic agent utilized as maintenance treatment for schizophrenia and mood disorders formulated as an ester for intramuscular injection. |
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T10989 |
Dehydroaripiprazole
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OPC-14857,DM-14857 |
5-HT Receptor
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Dehydroaripiprazole (DM-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroaripiprazole. Dehydroaripiprazole has anti... |
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T0365 |
Thioridazine hydrochloride
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Mellaril,Aldazine |
Apoptosis
,
Potassium Channel
,
Dopamine Receptor
,
5-HT Receptor
,
Antibacterial
,
Adrenergic Receptor
,
Autophagy
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Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity. |
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T0246 |
Betahistine dihydrochloride
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PT-9,Betahistine 2HCl |
Histamine Receptor
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Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator. |
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T0031L2 |
Ziprasidone
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Geodon,Zeldox,CP-88059 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
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Ziprasidone (Geodon) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
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T26375 |
(S)-Amisulpride
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Esamisulpride,(S) Amisulpride,SEP-4199 |
Dopamine Receptor
,
5-HT Receptor
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(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a Ki of 900 nM. (S)-Amisulpride has antipsychotic and antidepr... |
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T1180 |
Blonanserin
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AD-5423 |
Dopamine Receptor
,
Sigma receptor
,
5-HT Receptor
,
Adrenergic Receptor
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Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal ... |
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T2306 |
Brexpiprazole
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OPC-34712 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
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Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors. |
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T1567 |
Olanzapine
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LY170053 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
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Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. |
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T8389 |
Trifluoperazine
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trifluoroperazine |
CaMK
,
Dopamine Receptor
,
Influenza Virus
,
Adrenergic Receptor
,
P-gp
,
Autophagy
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Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia. |
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T0455 |
Clozapine
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HF 1854,LX 100-129 |
Dopamine Receptor
,
Adrenergic Receptor
,
AChR
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Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a... |
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T8690 |
Brexpiprazole HCl
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OPC 34712 dihydrochloride |
Others
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Brexpiprazole HCl (OPC 34712 dihydrochloride) is a new antipsychotic drug. |
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T22904 |
L-745870 trihydrochloride
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L-745,870 trihydrochloride |
Dopamine Receptor
,
Sigma receptor
,
5-HT Receptor
,
Adrenergic Receptor
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L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist. |
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T0031 |
Ziprasidone hydrochloride monohydrate
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CP 88059 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
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Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity. |
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T8136 |
Perospirone hydrochloride
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Perospirone HCl,SM-9018 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
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Perospirone hydrochloride (Perospirone HCl) is an atypical antipsychotic agent for the treatment of schizophrenia. It also displays affinity towards 5HT1A receptors as a partial agonist. |
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T1222 |
Trifluoperazine dihydrochloride
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Trifluoperazine 2HCl,SKF5019,Urinox |
CaMK
,
Dopamine Receptor
,
Influenza Virus
,
Adrenergic Receptor
,
P-gp
,
Autophagy
|
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Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic. |
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T0031L |
Ziprasidone hydrochloride
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CP-88059 hydrochloride,CP-88059,Ziprasidone HCl |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
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T5858 |
Sertindole
|
Lu 23-174 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Autophagy
|
|
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
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T26085 |
Rilapine
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Rilapinum |
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Rilapine is an atypical antipsychotic with high affinity for the 5-HT6 receptor. |
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T13620 |
Clothixamide
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Clotixamide |
Others
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Clothixamide（Clotixamide） is a thioxanthene derivative with antipsychotic activity. |
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T1105 |
Penfluridol
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R-16341,TLP-607 |
Calcium Channel
,
Dopamine Receptor
,
Autophagy
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Penfluridol (TLP-607) is a highly potent antipsychotic. |
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T8588 |
Buramate
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Antibacterial
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Buramate is an antipsychotic and anticonvulsant. |
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T3085 |
Piperacetazine
|
Psymod,Piperacetazinum,Quide |
Dopamine Receptor
,
5-HT Receptor
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Piperacetazine (Piperacetazinum), an antipsychotic prodrug, is used forschizophrenia. |
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T0561 |
2-Methoxy-5-sulfamoylbenzoic acid
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Others
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2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride. |
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T28267 |
ORM-10921
|
ORM10921,ORM 10921 |
Adrenergic Receptor
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ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies. |
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T28231 |
Olanzapine N-Oxide
|
|
Others
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Olanzapine N-Oxide is a metabolite of Olanzapine which shows antipsychotic activity. |
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T15352 |
FTBMT
|
|
GPR
|
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FTBMT is a selective GPR52 agonist (EC50: 75 nM) and has antipsychotic and procognitive properties. |
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T0302 |
Triflupromazine hydrochloride
|
Neoprin,Fluopromazine hydrochloride,Fluorofen,Flumazin |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Autophagy
|
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Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists. |
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T4007 |
Eticlopride hydrochloride
|
|
Dopamine Receptor
|
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Eticlopride, an antipsychotic, is a Selective dopamine D2/D3 receptor antagonist (Ki: 0.5/0.16 nM). |
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T17072 |
Thiethylperazine dimaleate
|
Toresten,Thiethylperazine maleate,Norzine |
Dopamine Receptor
,
Antibacterial
,
ABC
,
Histamine Receptor
|
|
Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, anti-emetic, and antipsychotic e... |
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T2190 |
Methiothepin mesylate
|
Ro 8-6837 mesylate,Metitepine mesylate |
Dopamine Receptor
,
5-HT Receptor
|
|
Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic. |
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T4275 |
Fluanisone
|
Sedalande,Haloanison |
Others
|
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Fluanisone (Haloanison) is a butyrophenone derivative with sedative properties. It is a typical antipsychotic and is used in the treatment of schizophrenia. |
