Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor function and corticotropin-releasing factor (CRF) levels in the rat brain.
説明 | Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor function and corticotropin-releasing factor (CRF) levels in the rat brain. |
In vivo | Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions[2]. |
動物実験 | Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions, reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex[2]. |
別名 | CXB-722 |
分子量 | 187.24 |
分子式 | C9H17NO3 |
CAS No. | 69542-93-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49 mg/mL (261.69 mM)
You can also refer to dose conversion for different animals. 詳細
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Pivagabine 69542-93-4 Membrane transporter/Ion channel Neuroscience GABA Receptor blood-brain γ-Aminobutyric acid Receptor psychoactive derivative Inhibitor inhibit foot factor barrier CXB722 CXB-722 shock Gamma-aminobutyric acid Receptor CXB 722 neuromodulatory corticotropin-releasing inhibitor