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138

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T36865	Heat Shock Protein Inhibitor II
	Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hs...
T2444	KNK437	Heat Shock Protein Inhibitor I	HSP
	KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).		HSP
T80964	Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)
	Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) acts as a T cell proliferation activator by promoting the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner and is utilized...
T8668	HM03		HSP
	HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.		HSP
T3594	ML346		HSP
	ML346 is a novel activator of Hsp70.		HSP
T4125	HSF1A		HSP
	HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.		HSP
T6248	XL888		HSP
	XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis....		HSP
T3652	KRIBB11		Apoptosis , HSP
	KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.		Apoptosis , HSP
T3487	HSP70-IN-1		Others , HSP
	HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).		Others , HSP
T8858	DTHIB		HSP
	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.		HSP
T5008	Teprenone	Tetraprenylacetone,Geranylgeranylacetone	HSP
	Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).		HSP
T3527	TRC051384	TRC 051384	HSP
	TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated ...		HSP
T6855	HA15		Apoptosis , GPR , Others , HSP , Autophagy
	HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.		Apoptosis , GPR , Others , HSP , Autophagy
T7010	VER-155008	VER155008	GPR , HSP , Autophagy
	VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.		GPR , HSP , Autophagy
T6558	KW-2478	KW2478	HSP
	KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.		HSP
T10860	Col003		HSP
	Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It can be used for the investigation of fibrosis.		HSP
T16994	Pimitespib	TAS-116	HSP
	Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).		HSP
T5350	JG-98	JG98,JG 98	Apoptosis , HSP
	JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).		Apoptosis , HSP
T9202	DDO-5936		HSP
	DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.		HSP
T2309	Ganetespib	STA-9090	Apoptosis , HSP , HIF
	Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.		Apoptosis , HSP , HIF
T3293	Apoptozole	Apoptosis Activator VII	Apoptosis , HSP
	Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.		Apoptosis , HSP
T6284	Onalespib	AT13387,Onalespib (AT13387)	HSP
	Onalespib (AT13387) is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chap...		HSP
T8157	Centhaquin	PMZ-2010,Centhaquine	Others
	Centhaquin (Centhaquine)e is an adrenergic receptor potentially for the treatment of postoperative pain and for the resuscitation of hypovolemic shock		Others
T8901	YUM70		Apoptosis , GPR , HSP
	YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate...		Apoptosis , GPR , HSP
T7265	HSP27 inhibitor J2	J2	HSP
	HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.		HSP
T0756	Ethoxyquin	Santoquin,Quinol,Santoflex	HSP , Reactive Oxygen Species
	Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.		HSP , Reactive Oxygen Species
T3454	VER-49009	CCT 129397	HSP
	VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).		HSP
T7261	Grp94 Inhibitor-1		GPR , HSP
	Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).		GPR , HSP
T8958	PU-H54		GPR
	PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94.		GPR
T21551	2-hexyl-4-Pentynoic Acid		HDAC
	2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.		HDAC
T2114	VER-82576	NVP-BEP800	HSP
	VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.		HSP
T9804	NPX800	CCT361814	HSP
	NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.		HSP
T6609	NMS-E973		HSP
	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.		HSP
T7661	SD-169	SD 169	p38 MAPK
	SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.		p38 MAPK
T13554	Arimoclomol maleate	BRX-220	HSP
	Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.		HSP
T5152	MKT-077	MKT 077,FJ-776,MKT077	HSP
	MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability to inhibit members of the Hsp70 family of molecular ...		HSP
T2286	BIIB021	BIIB 021,CNF2024,BIIB-021	HSP , Autophagy
	BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).		HSP , Autophagy
T6118	NVP-HSP990	HSP990	Apoptosis , HSP
	NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).		Apoptosis , HSP
T6210	Pifithrin-μ	PFTμ,NSC 303580,2-Phenylethynesulfonamide	HSP , p53 , Autophagy
	Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.		HSP , p53 , Autophagy
T12492	Pivagabine	CXB-722	GABA Receptor
	Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor...		GABA Receptor
T2258	VER-50589	VER50589	Apoptosis , HSP
	VER-50589 is a potent HSP90 inhibitor.		Apoptosis , HSP
T13553	Arimoclomol	BRX-220 free base	HSP
	Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).		HSP
T1989	Luminespib	AUY922,VER-52296,NVP-AUY922	Apoptosis , HSP , Autophagy
	Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).		Apoptosis , HSP , Autophagy
T5593	L-Alanyl-L-glutamine	Ala-Gln	Others , Endogenous Metabolite
	L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals with better solubility and stability than glutamine (Gln).		Others , Endogenous Metabolite
T22419	S-Methylisothiourea sulfate	(S)-Methylisothiourea sulfate	NOS , NO Synthase , HSV
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].		NOS , NO Synthase , HSV
T6297	Alvespimycin hydrochloride	BMS 826476,NSC 707545,KOS-1022,17-DMAG hydrochloride,Alvespimycin (17-DMAG) HCl	Apoptosis , HSP
	Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.		Apoptosis , HSP
T6442	CH5138303		HSP
	CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.		HSP
T6804	Chetomin	Chaetomin,NSC289491,BRN0077366	Apoptosis , HSP , HIF
	Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.		Apoptosis , HSP , HIF
T3515	TRC051384 HCl		HSP
	TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.		HSP
T23480	U-83836E		Others
	U-83836E (lazaroid ) has neuroprotective activity and anti-tumor activity, inhibits glioma cell proliferation, inhibits tumor necrosis factor and reverses endotoxin-induced shock.		Others

Compounds

Heat Shock Protein Inhibitor II

Synonym: Heat Shock Protein Inhibitor I

Target: HSP

Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)

Target: Apoptosis, HSP

Synonym: Tetraprenylacetone,Geranylgeranylacetone

Target: Apoptosis, GPR, Others, HSP, Autophagy

VER-155008

T7010

Synonym: VER155008

Target: GPR, HSP, Autophagy

Target: Apoptosis, HSP

Target: Apoptosis, HSP, HIF

Apoptozole

T3293

Synonym: Apoptosis Activator VII

Target: Apoptosis, HSP

Onalespib

T6284

Synonym: AT13387,Onalespib (AT13387)

Target: HSP

Centhaquin

T8157

Synonym: PMZ-2010,Centhaquine

Target: Apoptosis, GPR, HSP

Synonym: Santoquin,Quinol,Santoflex

Target: HSP, Reactive Oxygen Species

2-hexyl-4-Pentynoic Acid

Synonym: MKT 077,FJ-776,MKT077

Target: HSP

BIIB021

T2286

Synonym: BIIB 021,CNF2024,BIIB-021

Target: HSP, Autophagy

NVP-HSP990

T6118

Synonym: HSP990

Target: Apoptosis, HSP

Pifithrin-μ

T6210

Synonym: PFTμ,NSC 303580,2-Phenylethynesulfonamide

Target: HSP, p53, Autophagy

Pivagabine

T12492

Synonym: CXB-722

Target: GABA Receptor

VER-50589

T2258

Synonym: VER50589

Target: Apoptosis, HSP

Arimoclomol

T13553

Synonym: BRX-220 free base

Target: HSP

Luminespib

T1989

Synonym: AUY922,VER-52296,NVP-AUY922

Target: Apoptosis, HSP, Autophagy

L-Alanyl-L-glutamine

T5593

Synonym: Ala-Gln

Target: Others, Endogenous Metabolite

S-Methylisothiourea sulfate

T22419

Synonym: (S)-Methylisothiourea sulfate

Target: NOS, NO Synthase, HSV

Alvespimycin hydrochloride

T6297

Synonym: BMS 826476,NSC 707545,KOS-1022,17-DMAG hydrochloride,Alvespimycin (17-DMAG) HCl

Target: Apoptosis, HSP

Synonym: Chaetomin,NSC289491,BRN0077366

Target: Apoptosis, HSP, HIF

カタログ番号	製品名	別名	ターゲット
TQ0280	Feretoside		HSP
	Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).		HSP
T8189	Dihydroberberine		Potassium Channel , HSP , HER
	Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interacti...		Potassium Channel , HSP , HER
T21883	Gedunin		HSP
	Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.		HSP
T5826	Eupalinolide A		HSP
	Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.		HSP
TN6729	Azadiradione	AZD	Others
	Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica		Others
T6343	Geldanamycin	NSC 122750	HSP , Influenza Virus , Tyrosine Kinases , Antibacterial , Antibiotic
	Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
TJS0928	Calenduloside E	Silphioside F	Others
	Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by inhibiting glucose transport at the brush border of the small intesti...		Others
T8149	Dobutamine hydrochloride	Dobutamine (hydrochloride)	Adrenergic Receptor
	Dobutamine hydrochloride (Dobutamine (hydrochloride)) is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects.		Adrenergic Receptor
T2908	Palmitic acid	Hexadecoic acid,hexadecanoic acid,Cetylic acid	HSP , Endogenous Metabolite
	Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms. Palmitic acid has antitumor activity.		HSP , Endogenous Metabolite
T2230	Paeoniflorin	Peoniflorin	HSP , COX
	Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.		HSP , COX
TQ0131	Rocaglamide	Rocaglamide A,Roc-A	HSP , NF-κB , PERK
	Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.		HSP , NF-κB , PERK
T0974	Novobiocin Sodium	Albamycinsodium,Cathomycin,Albamycin	Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy
	Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim...
T6290	Tanespimycin	17-AAG,CP 127374,NSC 330507,KOS 953	Apoptosis , Mitophagy , HSP , Antibacterial , Antibiotic , Autophagy
	Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T8304	Anisodamine Hydrobromide	6-Hydroxyhyoscyamine	Adrenergic Receptor , AChR
	Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.		Adrenergic Receptor , AChR
T0970	Racanisodamine	Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine	Adrenergic Receptor , AChR
	Racanisodamine (7β-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.		Adrenergic Receptor , AChR
T6662	Scopine	6,7-Epoxytropine	Adrenergic Receptor
	Scopine (6,7-Epoxytropine), the metabolite of anisodine, is an α1-adrenergic receptor agonist used in the therapy of acute circulatory shock.		Adrenergic Receptor
T21532	Anisodamine	6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine	AChR
	Anisodamine (6-beta-Hydroxyhyoscyamine) is an antagonist of muscarinic and nicotinic cholinoceptor with similar affinities at the muscarinic receptor as scopolamine and atropine. Anisodamine improve the microcirculation ...		AChR
TN6774	Emodin 6-O-β-D-glucoside	Glucoemodin	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ...		Others
T4904	1-Methylguanidine hydrochloride		Others , Endogenous Metabolite
	Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibit...		Others , Endogenous Metabolite
T4839	Ac-Ala-OH	N-Acetylalanine,N-Acetyl-L-alanine	Others , Endogenous Metabolite
	Ac-Ala-OH (N-Acetyl-L-alanine) is a substrate for Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Myelin basic protein, GTP-binding nuclear protein Ran, Tropomyosin alpha 4 chain, HIV-1 Rev binding pro...		Others , Endogenous Metabolite
T3729	Ethyl gallate	Nipagallin A,Phyllemblin,gallic acid ethyl ester	MMP , NF-κB , Akt , Antibacterial
	Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib...		MMP , NF-κB , Akt , Antibacterial
T4S0350	Licochalcone B		Beta Amyloid , Others
	1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licoc...		Beta Amyloid , Others
T5136	Kongensin A
	Kongensin A is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications.
TN3572	Calyxin H		HSP
	Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.		HSP
T10034	(R)-10,11-Dehydrocurvularin	10,11-Dehydrocurvularin	Others
	10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response. It inhibits the TGF-β signaling pathway and has anti-tumorous activity.		Others
TN3839	Desoxo-narchinol A		ERK , IL Receptor , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor , JNK
	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO production. Desoxo-narchinol A shows cytot...
T75533	Dihydromaniwamycin E
	Dihydromaniwamycin E is a heat-shock metabolite exhibiting antiviral activity against influenza and SARS-CoV-2 viruses [1].
TN4013	Esculentic acid		IL Receptor , TNF , COX
	Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflammatory cytokines and mediators, and protei...		IL Receptor , TNF , COX
TN3366	Ailanthoidol		IL Receptor , NOS , COX , Prostaglandin Receptor , PPAR
	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemopreventive agent against tumor promotion. Ailan...		IL Receptor , NOS , COX , Prostaglandin Receptor , PPAR
TN6613	Delphinidin-3-O-galactoside chloride
	Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity. D3G is capable of masking the EGCG-induced cyto...
T83319	4-epi-Withaferin A
	4-epi-Withaferin A (compound 28), an analogue of Withaferin A, exhibits enhanced cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). It shows promise for the investigation of protein aggregation-associate...

天然物製品

Target: Potassium Channel, HSP, HER

Target: HSP, Influenza Virus, Tyrosine Kinases, Antibacterial, Antibiotic

Calenduloside E

TJS0928

Synonym: Silphioside F

Target: Others

Dobutamine hydrochloride

T8149

Synonym: Dobutamine (hydrochloride)

Target: Adrenergic Receptor

Palmitic acid

T2908

Synonym: Hexadecoic acid,hexadecanoic acid,Cetylic acid

Target: HSP, Endogenous Metabolite

Synonym: Rocaglamide A,Roc-A

Target: HSP, NF-κB, PERK

Novobiocin Sodium

T0974

Synonym: Albamycinsodium,Cathomycin,Albamycin

Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy

Tanespimycin

T6290

Synonym: 17-AAG,CP 127374,NSC 330507,KOS 953

Target: Apoptosis, Mitophagy, HSP, Antibacterial, Antibiotic, Autophagy

Anisodamine Hydrobromide

T8304

Synonym: 6-Hydroxyhyoscyamine

Target: Adrenergic Receptor, AChR

Racanisodamine

T0970

Synonym: Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine

Target: Adrenergic Receptor, AChR

Scopine

T6662

Synonym: 6,7-Epoxytropine

Target: Adrenergic Receptor

Anisodamine

T21532

Synonym: 6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine

Target: AChR

Emodin 6-O-β-D-glucoside

TN6774

Synonym: Glucoemodin

Target: Others

1-Methylguanidine hydrochloride

T4904

Synonym:

Target: Others, Endogenous Metabolite

Ac-Ala-OH

T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine

Target: Others, Endogenous Metabolite

Ethyl gallate

T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester

Target: MMP, NF-κB, Akt, Antibacterial

Licochalcone B

T4S0350

Synonym:

Target: Beta Amyloid, Others

(R)-10,11-Dehydrocurvularin

T10034

Synonym: 10,11-Dehydrocurvularin

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor, JNK

Target: IL Receptor, TNF, COX

Ailanthoidol

TN3366

Synonym:

Target: IL Receptor, NOS, COX, Prostaglandin Receptor, PPAR

Delphinidin-3-O-galactoside chloride

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02443	HSP70 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	HSP70 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 72.2 kDa and the accession number is A8K5I0.
TMPY-01478	HSP90 alpha Protein, Human, Recombinant	Human	E. coli
	HSP90 alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.6 kDa and the accession number is K9JA46.
TMPY-06092	HSP70 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	HSP70 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.6 kDa and the accession number is A6KTP2.
TMPH-00593	DnaK Protein, E. coli, Recombinant (Yeast, His)	E. coli	P. pastoris (Yeast)
	Acts as a chaperone.
TMPH-00592	DnaK Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Acts as a chaperone.
TMPJ-01080	HSF2 Protein, Human, Recombinant (His)	Human	E. coli
	Heat Shock Factor Protein 2 (HSF2) belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. In higher eukaryotes, HSF is unable to bind to t...
TMPH-03467	CspA Protein, Salmonella enteritidis, Recombinant (His & Myc)	Salmonella enteritidis	E. coli
	Binds to and stimulates the transcription of the CCAAT-containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3'. CspA Protein, Salmonella enteritidis, Recomb...
TMPY-02072	HSF1 Protein, Human, Recombinant (His)	Human	E. coli
	Heat shock factor protein 1, also known as heat shock transcription factor 1, HSF1, and HSTF1, is a cytoplasm and nucleus protein that belongs to the HSF family. HSF1 is the major transcription factor of HSPs (heat shock...
TMPY-01924	HSP60 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	HSP60 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 62.3 kDa and the accession number is P63038-1.
TMPJ-01411	HSPB11 Protein, Human, Recombinant (His)	Human	E. coli
	Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT2...
TMPJ-00754	CRYAA Protein, Human, Recombinant (His)	Human	E. coli
	Alpha-Crystallin A Chain (CRYAA) belongs to the small heat shock protein (HSP20) family and can be induced by heat shock. The expression of CRYAA is preferentially restricted to the lens cell. CRYAA may contribute to the...
TMPY-06091	HSP70 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	HSP70 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.5 kDa and the accession number is Q3TU85.
TMPH-00071	AtHsp23.6 Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	E. coli
	AtHsp23.6 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.4 kDa and the accession number is Q96331.
TMPY-04804	Cpn10/HSPE1 Protein, Human, Recombinant (His)	Human	E. coli
	Cpn10/HSPE1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 13.2 kDa and the accession number is A0A384N6A4.
TMPJ-01372	Cornulin Protein, Human, Recombinant (His)	Human	E. coli
	Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-ter...
TMPH-00708	DegP Protein, E. coli, Recombinant (His)	E. coli	P. pastoris (Yeast)
	DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm fo...
TMPH-00887	AHSA1 Protein, Human, Recombinant (GST)	Human	E. coli
	Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a re...
TMPJ-00915	HSP40 Protein, Human, Recombinant (His)	Human	E. coli
	DnaJ Homolog Subfamily B Member 1 (DNAJB1) is a member of the heat shock protein family. Heat shock proteins (HSPs) are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperon...
TMPY-01876	HSP60 Protein, Human, Recombinant (His & GST)	Human	E. coli
	HSP60 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 88.7 kDa and the accession number is A0A024R3X4.
TMPJ-01382	HSPB8 Protein, Human, Recombinant (His)	Human	E. coli
	Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in t...
TMPY-06846	HSP90 alpha Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	HSP90 alpha Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.19 kDa and the accession number is NP_032328.2.
TMPJ-00755	CRYAB Protein, Human, Recombinant (His)	Human	E. coli
	α Crystallin B Chain (CRYAB) is a cytoplasmic protein that belongs to the small heat shock protein (HSP20) family. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectiv...
TMPY-06845	HSP90 alpha Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	HSP90 alpha Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.06 kDa and the accession number is NP_005339.3.
TMPY-02217	HSC70 Protein, Human, Recombinant (His)	Human	E. coli
	HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised of both heat-inducible and constitutively expressed m...
TMPJ-00995	Serpin H1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Serpin H1 is a serine proteinase inhibitors Which belongs to the serpin family. Serpin H1 is induced by heat shock. Serpin H1 localizes to the endoplasmic reticulum lumen and binds specifically to collagen. Thus it is th...
TMPH-00729	RpoH Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. Intrac...
TMPH-01285	EEF1D Protein, Human, Recombinant (His)	Human	E. coli
	EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; Regulates induction of heat-shock-responsive g...
TMPK-00693	HSP27/HSPB1 Protein, Human, Recombinant (His)	Human	E. coli
	Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat shock protein involved in many cellular processes and reportedly protects cells against oxidative stress. This protein is expressed only in insulin-d...
TMPK-00015	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell prolifer...
TMPK-00016	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell prolifer...
TMPH-03579	TSST-1 Protein, S. aureus, Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Responsible for the symptoms of toxic shock syndrome. TSST-1 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37.9 kDa and th...
TMPY-03854	TMED4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TMED4, also known as ERS25, belongs to the EMP24/GP25L family. TMED4 may play a role in the regulation of heat-shock response and apoptosis. It is involved in vesicular protein trafficking, mainly in the early secretory ...
TMPY-00342	TMED4 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	TMED4, also known as ERS25, belongs to the EMP24/GP25L family. TMED4 may play a role in the regulation of heat-shock response and apoptosis. It is involved in vesicular protein trafficking, mainly in the early secretory ...
TMPH-03546	Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S....
TMPH-03548	Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His)	Staphylococcus aureus	P. pastoris (Yeast)
	Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S....
TMPH-03594	Exotoxin type A Protein, S. pyogenes, Recombinant (His & SUMO)	Streptococcus pyogenes	E. coli
	Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever. Exotoxin type A Protein, S. pyog...
TMPH-03073	TDX Protein, Japonica rice, Recombinant (His & Myc)	Rice	E. coli
	Probable thiol-disulfide oxidoreductase that may participate in various redox reactions and act as chaperone under heat shock. May interact with HSP70 proteins through the TPR repeats. TDX Protein, Japonica rice, Recombi...
TMPH-03547	Enterotoxin type G Protein, S. aureus (strain Mu50/ATCC 700699), Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S....
TMPK-00993	Coagulation Factor III/Tissue Factor Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	Tissue factor (also named Coagulation Factor III) is a cell surface glycoprotein responsible for initiating the extrinsic pathway of coagulation.Tissue factor is the primary cellular initiator of blood coagulation via in...
TMPH-03721	IbpA Protein, Yersinia pestis bv. Antiqua, Recombinant (His)	Yersinia pestis	E. coli
	Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the Ibp...
TMPH-01251	DUSP26 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis...
TMPK-00745	PGLYRP1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he...
TMPK-00749	PGLYRP1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he...
TMPY-01577	ORP150 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Hypoxia up-regulated protein 1, also known as 15 kDa oxygen-regulated protein, 17 kDa glucose-regulated protein, ORP-15, GRP-17, and HYOU1, is a member of the heat shock protein 7 family. Seven members from four differen...
TMPJ-00679	SGTA Protein, Human, Recombinant (His)	Human	E. coli
	Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein α (SGTA) is an ubiquitously expressed protein which belongs to the SGT Family. SGTA contains three TPR Protein-Protein Interaction Duplicates. SGTA is a co...
TMPJ-01074	PKCE Protein, Human, Recombinant (His)	Human	E. coli
	Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these doma...
TMPH-00085	SIZ1 Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	E. coli
	E3 SUMO protein ligase involved in regulation processes. Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses. Functions as an upstream negative regulator of s...
TMPY-04425	PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated...