Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 91,500 | |||
25 mg | 在庫あり | ¥ 152,500 | |||
50 mg | 在庫あり | ¥ 217,000 | |||
100 mg | 在庫あり | ¥ 294,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 64,000 |
説明 | RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1]. |
ターゲット&IC50 | RORγ:63.8 nM |
In vitro | RORγt inverse agonist 13 (Compound 3i) shows an inhibition of 76% at 0.3?μM in Th17 cell differentiation assay[1]. |
In vivo | RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model[1]. |
分子量 | 513.29 |
分子式 | C23H17Cl2F3N2O4 |
CAS No. | 2170477-75-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (19.48 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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RORγt inverse agonist 13 2170477-75-3 Metabolism ROR RORγt inverse agonist-13 RAR-related orphan receptor inhibit RORγt inverse agonist13 RORrt inverse agonist 13 Inhibitor RORgammat inverse agonist 13 inhibitor