Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 35,500 | |||
25 mg | 在庫あり | ¥ 66,500 | |||
50 mg | 在庫あり | ¥ 91,000 | |||
100 mg | 在庫あり | ¥ 136,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 26,000 |
説明 | SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist. |
In vitro | SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. |
In vivo | In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. |
動物実験 | Animal Models: RatFormulation: DMSODosages: 2.5 nMAdministration: Intracerebroventricular administration(Only for Reference) |
別名 | Smoothened Agonist HCl |
分子量 | 526.52 |
分子式 | C28H29Cl2N3OS |
CAS No. | 2095432-58-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 38 mg/mL (72.2 mM)
DMSO: 66 mg/mL (125.4 mM)
You can also refer to dose conversion for different animals. 詳細
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SAG hydrochloride (912545-86-9(free base)) 2095432-58-7 GPCR/G Protein Stem Cells Hedgehog/Smoothened SAG hydrochloride (912545 86 9(free base)) Smoothened Agonist HCl SAG hydrochloride (912545869(free base)) Inhibitor inhibitor inhibit