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T3278 |
Piribedil
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EU-4200,Trivastan,ET-495,Trivastal |
Dopamine Receptor
,
Histone Methyltransferase
,
Adrenergic Receptor
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Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease. |
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T21935L |
AMN082 free base
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AMN082 |
GluR
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AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist. |
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T6140 |
SB-334867 free base
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SB334867A free base,SB-334867,SB 334867,SB334867 |
OX Receptor
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SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist. |
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T21935 |
AMN082
|
AMN 082 dihydrochloride |
GluR
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AMN082 (AMN 082 dihydrochloride) is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity. |
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T35033 |
Vamicamide
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FK 176,FK-176,FK176 |
AChE
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Vamicamide (FK 176) is a novel anticholinergic compound. Vamicamide increases spontaneous locomotor activity in mice at 32 mg/kg (p.o.) or higher and inhibits cataleptic convulsions in mice at 100 mg/kg. |
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T35033L |
(S)-Vamicamide
|
(S)-Vamicamide (Iso-132373-81-0) |
AChE
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(S)-Vamicamide is a novel anticholinergic compound.Vamicamide increases spontaneous locomotor activity in mice at 32 mg/kg or higher (p.o.) and inhibits tonic convulsions in mice at 100 mg/kg.CAS 번호13483-86-1 |
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TP1940L1 |
Ac-RYYRIK-NH2 acetate
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Opioid Receptor
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Ac-RYYRIK-NH2 acetate is an agonist at nociceptin/orphanin FQ(noc/OFQ) receptors, affecting spontaneous locomotor activity. Ac-RYYRIK-NH2 acetate is a partial agonist on ORL1 transfected in CHO cells, antagonizes the sti... |
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T3685 |
SR9009
|
Stenabolic,REV-ERB Agonist II |
Autophagy
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|
SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during... |
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T21792 |
CGP 3466B maleate
|
Omigapil (Maleate),Omigapil maleate |
Apoptosis
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CGP 3466B maleate (Omigapil maleate) is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil male... |
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T37190 |
L-Allylglycine
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|
Dehydrogenase
,
GABA Receptor
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L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, ... |
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T32440 |
L 363572
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L363-572,L-363572,L-363-572,L363572,L 363-572 |
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L 363572, a hexapeptide analog of MK 678, does not effect locomotor acitivity in rats. |
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T81659 |
NocII TFA
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NocII TFA, an orphan neuropeptide, stimulates locomotor activity in mice [1]. |
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TP1982 |
Neuropeptide S(Rat)
|
Neuropeptide S (Rat) |
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Potent endogenous neuropeptide S receptor (NSPR) agonist (EC50 = 3.2 nM). Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice. |
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T75951 |
Neuropeptide S(Rat) TFA
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Neuropeptide S(Rat) TFA, a robust endogenous agonist for the neuropeptide S receptor (NSPR) with an EC50 of 3.2 nM, enhances locomotor activity and promotes wakefulness while concurrently diminishing anxiety-like behavio... |
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TP1983 |
Neuropeptide S (human)
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|
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Potent endogenous neuropeptide S receptor agonist (EC50 = 9.4 nM). Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice. |
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T28313 |
PD 117302
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PD-117302,PD117302 |
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PD 117302 is a nonpeptide opioid compound. It is a selective kappa-opioid agonist. PD 117302 causes naloxone-reversible locomotor impairment and diuresis. It is an Anti-Arrhythmia Agent, an Anticonvulsants, a Cardiovascu... |
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T29230 |
ZK-95962
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ZK-95962 is an agonist gamma-aminobutyric acid (GABA) receptor. ZK-95962 had selective effects on releasing exploratory locomotor activity suppressed by footshock (punished crossings). ZK-95962 had weak effects on the me... |
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T82587 |
Delta (Phospho) Sleep Inducing Peptide
|
DSIP-P |
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Delta (Phospho) Sleep Inducing Peptide (DSIP-P), a peptide that promotes sustained sleep, elicits alterations in circadian locomotor activity in rats [1] [2] [3]. |
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TP1980 |
Neuromedin S(rat)
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Neuromedin S (rat) |
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Potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent en... |
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T71327 |
Paraxanthine-d6
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Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the c... |
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T60270 |
(R)-Preclamol
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|
|
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(R)-Preclamol, a dopamine (DA) agonist, exhibits both autoreceptor and postsynaptic receptor stimulatory effects. It effectively reduces the locomotor activity in mice and rats at low doses [1]. |
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TP1981 |
Neuropeptide S(Mouse)
|
Neuropeptide S (Mouse) |
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Potent endogenous neuropeptide S receptor (NPSR) agonist (EC50 = 3 nM). Induces mobilization of intracellular Ca2+. Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice. |
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T29206 |
ZCZ011
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ZCZ 011,ZCZ-011 |
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ZCZ011 is a positive allosteric modulator of the cannabinoid CB1 receptor. ZCZ011 is brain penetrant, increased the potency of orthosteric agonists in mouse behavioral assays indicative of cannabimimetic activity, includ... |
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T35785 |
N-Oleoyl Leucine
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N-Oleoyl leucine is an N-acyl amide generated by PM20D1 that uncouples mitochondrial respiration independent of uncoupling protein 1 (UCP1) in vitro. N-Oleoyl leucine (25 mg/kg, i.p.) decreases body weight and food intak... |
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T75950 |
Neuropeptide S(Mouse) TFA
|
|
|
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Neuropeptide S(Mouse) TFA, an endogenous agonist for the neuropeptide S receptor (NPSR) with an EC50 value of 3 nM, plays a significant role in physiological processes by inducing the mobilization of intracellular Ca2+. ... |
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TP1940 |
Ac-RYYRIK-NH2
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|
|
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High affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties... |
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T38172 |
RO 5263397 hydrochloride
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|
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Potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhib... |
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T75915 |
CTOP TFA
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CTOP TFA, a potent and highly selective μ-opioid receptor antagonist, antagonizes acute analgesic effects and hypermotility, while enhancing extracellular dopamine levels in the nucleus accumbens. It also dose-dependentl... |
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T38221 |
N,N-Dipropyldopamine (hydrobromide)
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N,N-Dipropyldopamine is a dopamine receptor agonist.1,2,3 It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum of reserpinized rats (ED50s = 25 and 20 μmol/kg, respectively), as well as re... |
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T80900 |
Unasnemab
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MT-3921,rH116A3 |
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Unasnemab (MT-3921), a humanized IgG1 monoclonal antibody, targets repulsive guidance molecule A (RGMa) to enhance locomotor function and support neuroregeneration, showing potential for spinal cord injury research [1]. |
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TP1986 |
[Arg14,Lys15]Nociceptin
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Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasti... |
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T23099 |
O-2050
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Others
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O-2050 is a high affinity cannabinoid CB 1 receptor antagonist with a K i of 2.5 nM. O-2050 inhibits cannabinoid CB 2 receptor with Ki of 0.2 nM. O-2050 decreased food intake in mice and caused locomotor stimulation in m... |
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T71000 |
RO-5328673
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RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig... |
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TP1989 |
NEP(1-40)
|
Nogo-66 (1-40) |
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Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS ... |
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T83166 |
Adipokinetic hormone (Gryllus bimaculatus)
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Grybi-AKH |
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Adipokinetic hormone Gryllus bimaculatus (Grybi-AKH), an adipokinetic hormone, mobilizes lipids and carbohydrates from the insect fat body, effectively regulating energy homeostasis. It also enhances the locomotor activi... |
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T36499 |
CuATSM
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|
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The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Mutations in SOD1, which alter its metal binding capacity and can result in protein misfolding ... |
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T37094 |
(S)-UFR2709 hydrochloride
|
(S)-UFR2709 hydrochloride |
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(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol pre... |
