Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH 58261 is a potent and selective A2a adenosine receptor antagonist.The Ki =2.3 nM for rat A2a and 2 nM is for bovine A2a.
説明 | SCH 58261 is a potent and selective A2a adenosine receptor antagonist.The Ki =2.3 nM for rat A2a and 2 nM is for bovine A2a. |
ターゲット&IC50 | A2A (rat):2.3 nM(Ki), A2a (bovine):2.0 nM(Ki) |
In vitro | SCH 58261 causes the inhibition of rabbit platelet aggregation and porcine coronary artery relaxation by antagonizing competitively the effects induced by CGS 21680. [1] |
In vivo | In mice with Spinal cord injury, SCH58261 (0.01 mg/kg, i.p.) reduces demyelination and levels of TNF-α, Fas-L, PAR, Bax expression and activation of JNK MAPK. Chronic SCH58261 administration improves the neurological deficit up. [2] In rats with 6-OHDA-induced Parkinson's disease, SCH58261 (2 mg/kg, i.p.) improves the 6-OHDA-induced bradykinesia and motor disturbance. [3] |
別名 | SCH58261 |
分子量 | 345.36 |
分子式 | C18H15N7O |
CAS No. | 160098-96-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 34.5 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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SCH 58261 160098-96-4 GPCR/G Protein Neuroscience Adenosine Receptor Inhibitor inhibit SCH-58261 SCH58261 P1 receptor inhibitor