Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
ターゲット&IC50 | SIRT1:15 nM, SIRT3:33 nM, SIRT2:10 nM |
In vitro | SIRT-IN-1 is one of the most potent inhibitor of truncated pan SIRT1/ 2/3(IC50 values are 0.015, 0.010, 0.033 μM, respectively). SIRT-IN-1 binds identically in the catalytic active site (RMS=0.29 ), occupying the nicotinamide C-pocket and acetyl lysine substrate channel. |
分子量 | 389.52 |
分子式 | C19H27N5O2S |
CAS No. | 1431411-60-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 19.23 mg/mL (49.37 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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SIRT-IN-1 1431411-60-7 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor SIRT IN 1 SIRTIN1 inhibit inhibitor