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ターゲット

E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase Others Ligand for E3 Ligase

474

阻害剤

天然化合物

100

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T17879	E3 ligase Ligand 8		Others , Ligand for E3 Ligase
	E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoti...		Others , Ligand for E3 Ligase
T9809	E3 ligase Ligand 23		Ligand for E3 Ligase
	E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.		Ligand for E3 Ligase
T17870	CIAP1 ligand 1	E3 ligase Ligand 12	Others
	cIAP1 ligand 1 (E3 ligase Ligand 12) is an apoptotic protein ligand based on the LCL161 derivative that recruits IAP ubiquitin ligases to degrade target proteins, and can be used to couple with androgen receptor ligands ...		Others
T17872	E3 ligase Ligand 14		Others
	E3 ligase Ligand 14 is a ligand that binds to E3 ubiquitin ligase and can be conjugated to a protein ligand via a linker to create PROTACs. These PROTACs are capable of promoting ubiquitination-mediated degradation of ca...		Others
T17871	E3 ligase Ligand 13		Others
	E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degrad...		Others
T17876	E3 ligase Ligand 18		Others
	E3 ligase Ligand 18 is a ligand that binds to E3 ubiquitin ligase, and it can be chemically attached to a protein ligand through a linker to create PROTACs. The resulting PROTACs function as inducers of ubiquitination-me...		Others
T17880	E3 ligase Ligand 9		Others
	E3 ligase Ligand 9 is a compound that serves as a ligand for E3 ubiquitin ligase. It can be linked to the protein ligand through a linker, forming PROTACs or SNIPERs. These PROTACs are known to induce the degradation of ...		Others
T17868	E3 ligase Ligand 10		Others
	E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated d...		Others
T3103	L67	DNA Ligase Inhibitor	DNA , DNA/RNA Synthesis
	L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).		DNA , DNA/RNA Synthesis
T7755	Thalidomide 4-fluoride	E3 ligase Ligand 4	IRAK , Ligand for E3 Ligase
	Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) ...		IRAK , Ligand for E3 Ligase
T7763	Thalidomide-4-OH	Cereblon ligand 2,E3 ligase Ligand 2	Ligand for E3 Ligase
	Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs		Ligand for E3 Ligase
T7752	(S,R,S)-AHPC-Me	VHL ligand 2,E3 ligase Ligand 1A	Ligand for E3 Ligase
	(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a...		Ligand for E3 Ligase
T7753	Thalidomide-O-COOH	Cereblon ligand 3,E3 ligase Ligand 3,TCE35031	Others , Ligand for E3 Ligase
	Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs.		Others , Ligand for E3 Ligase
T79924	T4 RNA ligase		DNA/RNA Synthesis
	T4 RNA ligase is an enzyme that facilitates the ligation of single-stranded DNA. It is utilized for the synthesis of enzymatic oligoribonucleotides and the 3′-terminal labeling of RNA [1] [2].		DNA/RNA Synthesis
T13671	(S,R,S)-AHPC-Me hydrochloride	VHL ligand 2 hydrochloride,E3 ligase Ligand 1	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cell...		Others , Ligand for E3 Ligase
T17877	VH032-cyclopropane-F	VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101	Others , Ligand for E3 Ligase
	VH032-cyclopropane-F (Phenolic VH101) is a VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein by a linker to form PROTACs. PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4.		Others , Ligand for E3 Ligase
T17919	Thalidomide-O-amido-C6-NH2 TFA	E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA	Others , Ligand for E3 Ligase
	Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.		Others , Ligand for E3 Ligase
T17916	Pomalidomide-PEG4-C2-NH2	Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22	Others , Ligand for E3 Ligase
	Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and 4-unit PEG linker.		Others , Ligand for E3 Ligase
T15189	Thalidomide-O-amido-C4-N3	E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4	Others , Ligand for E3 Ligase
	Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.		Others , Ligand for E3 Ligase
T17325	Pomalidomide-PEG4-C-COOH	Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1	Others , E3 Ligase Ligand-Linker Conjugate
	Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.		Others , E3 Ligase Ligand-Linker Conjugate
T7759	Thalidomide-O-amido-C4-NH2 TFA	E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA	E3 Ligase Ligand-Linker Conjugate
	Thalidomide-O-amido-C4-NH2 TFA (E3 ligase Ligand-Linker Conjugates 19 TFA) is a synthesized E3 ligase ligand-linker conjugate.		E3 Ligase Ligand-Linker Conjugate
T7758	Thalidomide-O-amido-PEG3-C2-NH2 TFA	E3 ligase Ligand-Linker Conjugates 14 TFA,Cereblon Ligand-Linker Conjugates 3 (TFA)	Others , E3 Ligase Ligand-Linker Conjugate , Ligand for E3 Ligase
	Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-PEG3-C2-NH2 TFA incorporates the Thalidomide based cereblon ligand a...
T7760	Thalidomide-O-amido-C3-NH2 TFA	Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA	E3 Ligase Ligand-Linker Conjugate , Ligand for E3 Ligase
	Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-C3-NH2 TFA incorporates the Thalidomide based cereblon ligand and a linker...
T17918	Thalidomide-O-amido-PEG2-C2-NH2 TFA	E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA	Others , E3 Ligase Ligand-Linker Conjugate
	Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-PEG2-C2-NH2 TFA incorporates the Thalidomide based cereblon ligand a...		Others , E3 Ligase Ligand-Linker Conjugate
T17925	(S,R,S)-AHPC-PEG2-NH2	VH032-PEG2-NH2,VHL Ligand-Linker Conjugates 3,E3 ligase Ligand-Linker Conjugates 6 Free Base	Others , E3 Ligase Ligand-Linker Conjugate
	(S,R,S)-AHPC-PEG2-NH2 (VHL Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-NH2 incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis ...		Others , E3 Ligase Ligand-Linker Conjugate
T17909	(S,R,S)-AHPC-PEG3-N3	VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12	Others , E3 Ligase Ligand-Linker Conjugate , Ligand for E3 Ligase
	(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC tec...
T17920	(S,R,S)-AHPC-PEG1-N3	VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC tec...		Others , Ligand for E3 Ligase
T18640	(S,R,S)-AHPC-C4-NH2 hydrochloride	VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a linker.		Others , Ligand for E3 Ligase
T17921	(S,R,S)-AHPC-PEG4-N3	VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4	Others , PROTAC Linker
	(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both c...		Others , PROTAC Linker
T15190L	(S,R,S)-AHPC-PEG4-NH2	VHL Ligand-Linker Conjugates 4,E3 ligase Ligand-Linker Conjugates 7 Free Base,VH032-PEG4-NH2	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate comprising a VHL ligand based on (S,R,S)-AHPC and a 4-unit PEG linker.		Others , Ligand for E3 Ligase
T17924	(S,R,S)-AHPC-PEG2-NH2 hydrochloride	VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6	Others , E3 Ligase Ligand-Linker Conjugate
	(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-NH2 hydrochloride incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit...		Others , E3 Ligase Ligand-Linker Conjugate
T4517	L189		DNA , DNA/RNA Synthesis
	L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).		DNA , DNA/RNA Synthesis
T17922	(S,R,S)-AHPC-PEG3-NH2 hydrochloride	VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl	Others , E3 Ligase Ligand-Linker Conjugate
	(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC-based VHL ligand and 3-unit PEG linker.		Others , E3 Ligase Ligand-Linker Conjugate
T7756	Pomalidomide-PEG4-Ph-NH2		Ligand for E3 Ligase
	Pomalidomide-PEG4-Ph-NH2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.		Ligand for E3 Ligase
T18064	Lenalidomide-Br		Ligand for E3 Ligase
	Lenalidomide-Br (Compound 41) is a derivative of Lenalidomide, which serves as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound, Lenalidomide-Br, can be conjugated to a...		Ligand for E3 Ligase
T40503	Thalidomide-5-methyl		Ligand for E3 Ligase
	Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand. Thalidomide-5-methyl is used in the recruitment of CRBN protein.		Ligand for E3 Ligase
T18066	Lenalidomide-OH		Ligand for E3 Ligase
	Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. Additionally, Lenalidomide-OH can be conjugated to a protei...		Ligand for E3 Ligase
T18831	Thalidomide-propargyl		Others , Ligand for E3 Ligase
	Thalidomide-propargyl, a Thalidomide-derived Cereblon ligand, facilitates the recruitment of Cereblon. It can be attached to the protein ligand via a linker, producing IMiD-containing PROTACs.		Others , Ligand for E3 Ligase
T5334	VL285		Others , Ligand for E3 Ligase
	VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.		Others , Ligand for E3 Ligase
T14893	CC-885		Others , Ligand for E3 Ligase
	CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity.		Others , Ligand for E3 Ligase
T17869	CIAP1 ligand 2	E3 ligase Ligand 11	Others
	cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER.		Others
T22922	Lenalidomide hemihydrate		TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.		TNF , Ligand for E3 Ligase , Molecular Glues
TQ0121	VH-298		Others , HIF , Ligand for E3 Ligase
	VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by P...		Others , HIF , Ligand for E3 Ligase
T40019	Thalidomide-5-NH2-CH2-COOH		Others
	Thalidomide-5-NH2-CH2-COOH (compound 114) is a selective inhibitor of the protomyosin receptor kinase. It is a ligand for E3 ligase and has potential for studying one or more diseases.		Others
T0213	Thalidomide	Thalomid,Sedoval	Apoptosis , TNF , Autophagy , Ligand for E3 Ligase , Molecular Glues
	Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
T17874	Nutlin carboxylic acid	MDM2 ligand 1,E3 ligase Ligand 16	Others
	Nutlin Carboxylic Acid (MDM2 ligand 1), derived from Nutlin 3, serves as an MDM2 ligand. It can be attached to a protein ligand via a linker to create PROTACs[1].		Others
T17364	AhR Ligand-Linker Conjugates 1	E3 Ligase Ligand-Linker Conjugates 57	Others
	AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be ...		Others
T8824	CRBN modulator-1	WUN29654	Others , Ligand for E3 Ligase
	CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.		Others , Ligand for E3 Ligase
T1642	Lenalidomide	CC-5013	Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.		Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
T18826	Thalidomide-O-PEG2-propargyl	E3 ligase Ligand-Linker Conjugates 32	Others
	Thalidomide-O-PEG2-propargyl (E3 Ligase Ligand-Linker Conjugates 32) is a chemical compound that has been synthesized as a conjugate of an E3 ligase ligand and a linker. It incorporates the cereblon ligand based on Thali...		Others

Compounds

E3 ligase Ligand 8

T17879

Synonym:

Target: Others, Ligand for E3 Ligase

E3 ligase Ligand 23

T9809

Synonym:

Target: Ligand for E3 Ligase

cIAP1 ligand 1

T17870

Synonym: E3 ligase Ligand 12

Target: Others

E3 ligase Ligand 14

T17872

Synonym:

Target: Others

E3 ligase Ligand 13

T17871

Synonym:

Target: Others

E3 ligase Ligand 18

E3 ligase Ligand 10

Synonym: DNA Ligase Inhibitor

Target: DNA, DNA/RNA Synthesis

Thalidomide 4-fluoride

T7755

Synonym: E3 ligase Ligand 4

Target: IRAK, Ligand for E3 Ligase

Thalidomide-4-OH

T7763

Synonym: Cereblon ligand 2,E3 ligase Ligand 2

Target: Ligand for E3 Ligase

(S,R,S)-AHPC-Me

T7752

Synonym: VHL ligand 2,E3 ligase Ligand 1A

Target: Ligand for E3 Ligase

Thalidomide-O-COOH

T7753

Synonym: Cereblon ligand 3,E3 ligase Ligand 3,TCE35031

Target: Others, Ligand for E3 Ligase

T4 RNA ligase

T79924

Synonym:

Target: DNA/RNA Synthesis

(S,R,S)-AHPC-Me hydrochloride

T13671

Synonym: VHL ligand 2 hydrochloride,E3 ligase Ligand 1

Target: Others, Ligand for E3 Ligase

VH032-cyclopropane-F

T17877

Synonym: VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101

Target: Others, Ligand for E3 Ligase

Thalidomide-O-amido-C6-NH2 TFA

T17919

Synonym: E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA

Target: Others, Ligand for E3 Ligase

Pomalidomide-PEG4-C2-NH2

T17916

Synonym: Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22

Target: Others, Ligand for E3 Ligase

Thalidomide-O-amido-C4-N3

T15189

Synonym: E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4

Target: Others, Ligand for E3 Ligase

Pomalidomide-PEG4-C-COOH

T17325

Synonym: Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1

Target: Others, E3 Ligase Ligand-Linker Conjugate

Thalidomide-O-amido-C4-NH2 TFA

T7759

Synonym: E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide-O-amido-PEG3-C2-NH2 TFA

T7758

Synonym: E3 ligase Ligand-Linker Conjugates 14 TFA,Cereblon Ligand-Linker Conjugates 3 (TFA)

Target: Others, E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

Thalidomide-O-amido-C3-NH2 TFA

T7760

Synonym: Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA

Target: E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

Thalidomide-O-amido-PEG2-C2-NH2 TFA

T17918

Synonym: E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA

Target: Others, E3 Ligase Ligand-Linker Conjugate

(S,R,S)-AHPC-PEG2-NH2

T17925

Synonym: VH032-PEG2-NH2,VHL Ligand-Linker Conjugates 3,E3 ligase Ligand-Linker Conjugates 6 Free Base

Target: Others, E3 Ligase Ligand-Linker Conjugate

(S,R,S)-AHPC-PEG3-N3

T17909

Synonym: VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12

Target: Others, E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG1-N3

T17920

Synonym: VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-C4-NH2 hydrochloride

T18640

Synonym: VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG4-N3

T17921

Synonym: VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4

Target: Others, PROTAC Linker

(S,R,S)-AHPC-PEG4-NH2

T15190L

Synonym: VHL Ligand-Linker Conjugates 4,E3 ligase Ligand-Linker Conjugates 7 Free Base,VH032-PEG4-NH2

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

T17924

Synonym: VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6

Target: Others, E3 Ligase Ligand-Linker Conjugate

L189

T4517

Synonym:

Target: DNA, DNA/RNA Synthesis

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

T17922

Synonym: VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl

Target: Others, E3 Ligase Ligand-Linker Conjugate

Pomalidomide-PEG4-Ph-NH2

T7756

Synonym:

Target: Ligand for E3 Ligase

Lenalidomide-Br

T18064

Synonym:

Target: Ligand for E3 Ligase

Thalidomide-5-methyl

T40503

Synonym:

Target: Ligand for E3 Ligase

Lenalidomide-OH

T18066

Synonym:

Target: Ligand for E3 Ligase

Thalidomide-propargyl

T18831

Synonym:

Target: Others, Ligand for E3 Ligase

VL285

T5334

Synonym:

Target: Others, Ligand for E3 Ligase

CC-885

T14893

Synonym:

Target: Others, Ligand for E3 Ligase

cIAP1 ligand 2

T17869

Synonym: E3 ligase Ligand 11

Target: Others

Lenalidomide hemihydrate

T22922

Synonym:

Target: TNF, Ligand for E3 Ligase, Molecular Glues

VH-298

TQ0121

Synonym:

Target: Others, HIF, Ligand for E3 Ligase

Thalidomide-5-NH2-CH2-COOH

Synonym: Thalomid,Sedoval

Target: Apoptosis, TNF, Autophagy, Ligand for E3 Ligase, Molecular Glues

Nutlin carboxylic acid

T17874

Synonym: MDM2 ligand 1,E3 ligase Ligand 16

Target: Others

AhR Ligand-Linker Conjugates 1

T17364

Synonym: E3 Ligase Ligand-Linker Conjugates 57

Target: Others, Ligand for E3 Ligase

Lenalidomide

T1642

Synonym: CC-5013

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

Thalidomide-O-PEG2-propargyl

T18826

Synonym: E3 ligase Ligand-Linker Conjugates 32

Target: Others

カタログ番号	製品名	別名	ターゲット
T4S0181	Hinokiflavone		MMP , BCL , E1/E2/E3 Enzyme
	Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO...		MMP , BCL , E1/E2/E3 Enzyme
T9352	Hydrocotarnine		Others
	hydrocotarnine is an inhibitor of Cbl.		Others
T9368	3,4-(Methylenedioxy)cinnamic acid	3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid	Others
	3,4-(Methylenedioxy)cinnamic acid (3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid) is a plant-derived compound first extracted from roots of Asparagus officinalis and further characterized as an allelochemical.		Others
T4036	Solasodine	Solancarpidine,Purapuridine,Solasodin	Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
	Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma...		Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
T2947	Indole-3-carbinol	I3C,3-Indolemethanol,Indole-3-Methanol	E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53
	Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T6S2123	Ginkgolic Acid	Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),Ginkgolic acid C15:1	Others , E1/E2/E3 Enzyme
	Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.		Others , E1/E2/E3 Enzyme
T6407	β-Lapachone	Beta-Lapachone,NSC-26326,SL-11001,ARQ-501	IDO , Apoptosis , Topoisomerase , Autophagy
	β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.		IDO , Apoptosis , Topoisomerase , Autophagy
T4837	Itaconic acid	methylene-butanedioicaci	Others , Endogenous Metabolite
	Itaconic acid (methylene-butanedioicaci), also known as itaconate, belongs to the class of organic compounds known as branched fatty acids. These are fatty acids containing a branched chain. Itaconic acid exists as a sol...		Others , Endogenous Metabolite

天然物製品

Hinokiflavone

T4S0181

Synonym:

Target: MMP, BCL, E1/E2/E3 Enzyme

3,4-(Methylenedioxy)cinnamic acid

T9368

Synonym: 3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid

Target: Others

Solasodine

T4036

Synonym: Solancarpidine,Purapuridine,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

Indole-3-carbinol

T2947

Synonym: I3C,3-Indolemethanol,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

Ginkgolic Acid

T6S2123

Synonym: Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),Ginkgolic acid C15:1

Target: Others, E1/E2/E3 Enzyme

β-Lapachone

T6407

Synonym: Beta-Lapachone,NSC-26326,SL-11001,ARQ-501

Target: IDO, Apoptosis, Topoisomerase, Autophagy

Itaconic acid

T4837

Synonym: methylene-butanedioicaci

Target: Others, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-00475	DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His)	Desulfotalea psychrophila	E. coli
	DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His) is expressed in E. coli.
TMPH-00425	DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His)	Colwellia psychrerythraea	E. coli
	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential fo...
TMPH-00647	Lipoate-protein ligase A/LplA Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
TMPH-03533	Ddl Protein, S. aureus, Recombinant (His & Myc)	Staphylococcus aureus	E. coli
	Cell wall formation. Ddl Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.7 kDa and the accession number is P63891.
TMPY-00361	Pellino-1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant ce...
TMPJ-00732	ASS1 Protein, Human, Recombinant (His)	Human	E. coli
	Argininosuccinate Synthase (ASS1) is an urea cycle enzyme with a tetrameric structure composed of identical subunits. ASS1 is involved in the synthesis of arginine and catalyzes that condensation of citrulline and aspart...
TMPH-02527	ASS1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate f...
TMPH-02764	ACSL4 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	ACSL4 Protein, Mouse, Recombinant (His) is expressed in E. coli.
TMPJ-01122	KARS Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Lysine-tRNA ligase, also known as Lysyl-tRNA synthetase, LysRS, KARS and KIAA0070, belongs to the class-II aminoacyl-tRNA synthetase family. The N-terminal cytoplasmic domain (1-65) is a functional tRNA-binding domain, w...
TMPH-03740	DCL Protein, Bacillus subtilis, Recombinant (His)	Bacillus subtilis	E. coli
	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high ene...
TMPJ-00855	GLUL Protein, Human, Recombinant (His)	Human	E. coli
	Glutamine Synthetase reglutes intracellular concentration of glutamate. Glutamine Synthetase catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is an important source of energy and that takes part...
TMPY-01654	ITCH Protein, Human, Recombinant (aa 526-903)	Human	E. coli
	E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ub...
TMPH-03409	4CL Protein, Rhodobacter capsulatus, Recombinant (His)	Rhodobacter capsulatus	E. coli
	Converts p-coumaric acid into p-coumaryl CoA. This is necessary for the activation of the photoactive yellow protein (PYP) chromophore. 4CL Protein, Rhodobacter capsulatus, Recombinant (His) is expressed in E. coli expre...
TMPJ-00989	MTHFS Protein, Human, Recombinant (His)	Human	E. coli
	5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contr...
TMPY-02950	WWP2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thio...
TMPJ-01053	UBE2I Protein, Human, Recombinant (GST)	Human	E. coli
	SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin ho...
TMPJ-01035	UBE2G2 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 10...
TMPY-03510	Cbl-c Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, C...
TMPH-02488	ACSS2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity. ACSS2 Protein, Mouse, Recombinant (His) is expressed in E...
TMPK-01001	RNF43 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 i...
TMPJ-01403	UBE2D4 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational...
TMPY-06026	VHL Protein, Human, Recombinant (His & Avi)	Human	E. coli
	VHL Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is A0A024R2F2.
TMPH-01259	AMFR Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPJ-00985	UBE2A Protein, Human, Recombinant (GST, His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived prot...
TMPJ-01047	UBE2H Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived protei...
TMPJ-01198	UBE2R2 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex...
TMPJ-01334	UBE2Z Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. ...
TMPY-02922	XIAP Protein, Human, Recombinant (His)	Human	E. coli
	XIAP Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P98170.
TMPJ-00033	UBE2B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2...
TMPY-01216	XIAP Protein, Human, Recombinant (Avi)	Human	E. coli
	XIAP Protein, Human, Recombinant (Avi) is expressed in E. coli expression system with AVI tag. The predicted molecular weight is 29.1 kDa and the accession number is P98170.
TMPJ-01138	UBE2S Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activat...
TMPJ-00571	UBE2D3 Protein, Human, Recombinant	Human	E. coli
	UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubi...
TMPJ-01386	STUB1 Protein, Human, Recombinant	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its ...
TMPH-00877	ACSS1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation un...
TMPH-00876	ACSS1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation un...
TMPJ-01038	UBE2K Protein, Human, Recombinant (GST)	Human	E. coli
	UBE2K Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 45 KDa and the accession number is P61086.
TMPJ-01039	UBE2K Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	UBE2K Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis and SUMO tag. The predicted molecular weight is 38 KDa and the accession number is P61086.
TMPJ-00999	UBE2D1 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes...
TMPY-03650	BirA Protein, E. coli, Recombinant (His & MBP)	E. coli	E. coli
	The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. This enzyme is used to biotinylate the C termini of membrane proteins, allowing these prote...
TMPY-04153	RNF43 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPJ-00717	BAG2 Protein, Human, Recombinant (His)	Human	E. coli
	BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is...
TMPY-02521	HIST3H2A Protein, Human, Recombinant	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPH-01204	DCAF4 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
TMPH-02136	SPSB1 Protein, Human, Recombinant (His)	Human	E. coli
	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Nega...
TMPH-00732	RtcB Protein, E. coli, Recombinant (His)	E. coli	P. pastoris (Yeast)
	GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splici...
TMPH-01326	FBXO44 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO44 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag....
TMPH-01522	HIV-2 (subtype A, isolate ROD) Protein Vpx (His)	HIV-2	P. pastoris (Yeast)
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-02651	Fbxo3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and ...
TMPH-01203	DCAF16 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. DCAF16 Protein, Human, Recombinant...
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