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T8655 |
SR-717
|
|
STING
|
|
SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens. |
|
T13774 |
ML390
|
|
Others
,
Dehydrogenase
|
|
ML390 exerts its potent differentiation effect on multiple leukemia models. |
|
T11344 |
G150
|
|
DNA
,
cGAS
|
|
G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS). |
|
T9777 |
THP104c
|
|
Mitochondrial Metabolism
|
|
THP104c is an inhibitor of mitochondrial fission. |
|
T8477 |
IQ-3
|
|
JNK
|
|
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an... |
|
T74328 |
STING agonist-8 dihydrochloride
|
|
|
|
STING Agonist-8 Dihydrochloride (Compound 5-AB) is a highly effective STING agonist, exhibiting an EC50 value of 27 nM in THP1-Dual KI-hSTING-R232 cells. |
|
T29097 |
VAS 3947
|
VA-S3947,VA S3947,VAS3947 |
Apoptosis
,
NADPH-oxidase
|
|
VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX act... |
|
T26775 |
Bepafant
|
WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170 |
|
|
Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1... |
|
T39926 |
SR-717 free acid
|
|
|
|
SR-717 free acid is a stable cGAMP mimetic and a non-nucleotide STING agonist. It exhibits antitumor activity with EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively... |
|
T81667 |
NLRP3 agonist 2
|
|
NOD-like Receptor (NLR)
|
|
NLRP3 agonist 2 (compound 22) is an orally active agent that activates Caspase-1 in THP1 cells [1]. |
|
T78854 |
WK499
|
|
|
|
BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage. It effectively hampers the proliferation of various AML ce... |
|
T36798L |
SW2_110A acetate
|
|
Histone Methyltransferase
|
|
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate has a high affinity for CBX8N, inhibits the association bet... |
