Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL).
説明 | STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL). |
ターゲット&IC50 | CaM-KKα:0.25 μM(Ki), CaM-KKβ:47 nM(Ki) |
In vitro | STO-609 also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC50 value of the compound against CaM-KII is 10 μg/mL. STO-609 inhibits constitutively active CaM-KKα as well as the wild-type enzyme. In transfected HeLa cells, STO-609 dose-dependently suppresses the Ca2+-induced activation of CaM-KIV. STO-609 (1μg/mL) significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells (80%). |
別名 | STO 609 |
分子量 | 314.29 |
分子式 | C19H10N2O3 |
CAS No. | 52029-86-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.17 mg/mL (13.26 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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STO-609 52029-86-4 Autophagy Chromatin/Epigenetic Neuroscience PI3K/Akt/mTOR signaling CaMK AMPK AMP-activated protein kinase STO609 Calmodulin-dependent protein kinases STO 609 Inhibitor Calmodulin-dependent kinases inhibit inhibitor