Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. It exhibits antitumor effects in multiple animal models and Y cell lines.
説明 | SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. It exhibits antitumor effects in multiple animal models and Y cell lines. |
分子量 | 420.52 |
分子式 | C24H24N2O3S |
CAS No. | 222716-34-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1eq. HCl: 20 mM
DMSO: 1mg/ml, Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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SZL P1-41 222716-34-9 Apoptosis Others Ubiquitination E1/E2/E3 Enzyme E1 activating enzyme Ubiquitin ligase E2 conjugating enzyme Ubiquitin conjugating enzyme E3 ligating enzyme Inhibitor Ubiquitin activating enzyme SZL P-1-41 SZL P141 SZL P1 41 inhibit inhibitor