Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 49,000 |
2 mg | 在庫あり | ¥ 73,000 |
5 mg | 在庫あり | ¥ 123,000 |
10 mg | 在庫あり | ¥ 175,500 |
25 mg | 在庫あり | ¥ 259,500 |
50 mg | 在庫あり | ¥ 356,000 |
説明 | Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. |
In vitro | Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only Scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only Scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells[1] |
植物由来 |
分子量 | 327.37 |
分子式 | C19H21NO4 |
CAS No. | 6451-73-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Scoulerine 6451-73-6 Apoptosis Microbiology/Virology Neuroscience BACE Beta-Secretase Parasite proliferation Inhibitor cancer Beta-secretase inhibit microtubule cycle β-Secretase Microtubule/Tubulin leukemic cells division mitotic Discretamine inhibitor