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Search Results for " microtubule "

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258

阻害剤

46

天然化合物

34

リコンビナントタンパク質

2

ライブラリー

カタログ番号 製品名 別名 ターゲット
T71584 Microtubule Inhibitor 185322
Microtubule inhibitor 185322 is an inhibitor of microtubule assembly, inducung mitotic arrest and apoptosis of MM cells.
T12034 Microtubule inhibitor 1 Others
Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity(IC50 = 9-16 nM, in cancer cells).
T62448 Microtubule inhibitor 6
Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. microtubule inhibitor 6 exhibited cytotoxicity against NCI-H460 cells, BxPC-3 cells, and HT-29 cells, with IC50 values of 14.0, 6.6, and 7.0 nM, r...
T61749 Microtubule inhibitor 2
Microtubule inhibitor 2 is a highly potent and selective microtubule inhibitor, which is orally active. It induces cell death via ferroptosis, and exhibits notable antitumor activity [1].
T61765 Microtubule inhibitor 5
Microtubule inhibitor 5 (compound 17f) is a highly potent cytotoxic agent that inhibits microtubule function. It exhibits a substantial cytotoxic effect on NCI-H460 cells, with an IC50 value of 154.5 nM. Moreover, this c...
T62642 Microtubule inhibitor 4
Microtubule inhibitor 4 (compound 2) is a potent inhibitor of microtubule and inhibits microtubule protein polymerization, HT-29 cells (IC50: 2.1 nM) exhibited cytotoxicity.
T62867 Microtubule inhibitor 3
Compounds 17o (IC50: 14.0 nM, NCI-H460) and 17p (IC50: 2.9 nM, NCI-H460) with furan moieties showed potent cytotoxic effects at the nanomolar level against various human cancer cell lines.
TP1420 Microtubule-associated protein tau (26-44)
Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.
T62639 Microtubule inhibitor 7
Compounds 17o (IC50= 14.0 nM, NCI-H460) and 17p (IC50= 2.9 nM, NCI-H460) with furan moieties show potent nanomolar levels of cytotoxic activity against various human cancer cell lines.
T74166 Microtubule destabilizing agent-1
Microtubule destabilizing agent-1 (Compound 12b), a hydroxamic acid-based microtubule destabilizing agent (MDA), exhibits potent antitumor activity, favorable metabolic stability, and high bioavailability, making it a pr...
T79508 Microtubule stabilizing agent-1
Compound 3l, a paclitaxel derivative known as Microtubule Stabilizing Agent-1, effectively enhances tubulin polymerization and demonstrates antitumor efficacy [1].
T14349 Auristatin F Microtubule Associated
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.
T15236 Entasobulin Microtubule Associated
Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity.
T60026 KIF18A-IN-2 Microtubule Associated
KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.
T9504 MAP4343 Microtubule Associated
Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, resulting in enhanced neurite extension and protection of n...
T22661 CHM-1 Apoptosis , Others , Microtubule Associated
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
T39994 Sovilnesib AMG650 Microtubule Associated
Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.
T14348 Auristatin E Microtubule Associated
Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an...
T21632 Myoseverin Others , Microtubule Associated
Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and str...
T7800 TN-16 Microtubule Associated
TN-16 is a microtubule polymerization inhibitor (IC50 :0.4-1.7 μM)
T4077 PE859 Beta Amyloid , Gamma-secretase , Microtubule Associated
PE859 is a potent inhibitor of both tau and Aβ aggregation.
T14694 BNC105 Microtubule Associated
BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.
T8513 Spastazoline Others
Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ).
T5699 SSE15206 Apoptosis , Microtubule Associated
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
T8342 BRD9876 Others , Kinesin , Microtubule Associated
BRD9876 is a selective inhibitor of MM1S growth.
T6393 ARQ 621 Kinesin
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
T9974 Antiproliferative agent-13 Dehydrogenase
Antiproliferative agent-13 is a compound with antiproliferative activity.
T2511 Plinabulin NPI-2358 Microtubule Associated
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, the...
T6071 Parbendazole SKF 29044 Microtubule Associated , Parasite
Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infestations.
T2090 Lexibulin CYT-997 Apoptosis , Reactive Oxygen Species , Microtubule Associated
Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this...
T4232 VCMMAE mc-vc-PAB-MMAE Microtubule Associated
VCMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity.
T41248 Thiocolchicine Microtubule Associated
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
T4029 BTB-1 BTB 1,NSC156750 Microtubule Associated
BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
T14350 Soblidotin Auristatin PE,TZT-1027 Microtubule Associated
Soblidotin (TZT-1027) (Auristatin PE) is an inhibitor of tubulin polymerization. It is also a novel synthetic Dolastatin 10 derivative.
T15141 DM4 Ravtansine Others , Microtubule Associated
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
T4451 Estramustine phosphate sodium Ro 21-8837/001,Estramustine phosphate disodium Apoptosis , Microtubule Associated
Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
T71582 Niguldipine Free Base
Niguldipine Free Base is a calcium channel blocker and a₁-adrenergic receptor antagonist and a clinical modulator of multidrug resistance.
T6345 Tirbanibulin KX2-391,KX-01 Microtubule Associated , Src
Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cancer. It is a substrate-targeted kinase inhibit...
T1753 D-64131 Microtubule Associated
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.
T1758 ABT-751 E7010 Microtubule Associated , Autophagy
ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.
T50005 Sertaconazole Antifungal
Sertaconazole is a broad-spectrum antifungal.
T9812 Tubulin inhibitor 24 Microtubule Associated
Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.
T0838 Triclabendazole CGA89317 Microtubule Associated , Parasite
Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease.
T3256 MMAF MonoMethyl auristatin F Others , Microtubule Associated
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
T15012 Crolibulin EPC2407 Microtubule Associated
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.
T0009 Flubendazole Flumoxanal,Flumoxane,NSC 313680,Fluvermal Apoptosis , Microtubule Associated , Parasite
Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
T2802 Nocodazole R17934,Oncodazole Apoptosis , Microtubule Associated , Bcr-Abl , Autophagy , CRISPR/Cas9
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.
T2060 ELR510444 LR-510444,LR510444,LR 510444 Apoptosis , Microtubule Associated
ELR510444 (LR510444) is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpress...
T6075 Epothilone B Patupilone,EPO 906 Apoptosis , Microtubule Associated , Antibiotic , Antifungal
Epothilone B (EPO 906) is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditi...
T9595 LP-261 Microtubule Associated
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.

Compounds

Microtubule Inhibitor 185322
T71584
Synonym:
Target:
Microtubule inhibitor 1
T12034
Synonym:
Target: Others
Microtubule inhibitor 6
T62448
Synonym:
Target:
Microtubule inhibitor 2
T61749
Synonym:
Target:
Microtubule inhibitor 5
T61765
Synonym:
Target:
Microtubule inhibitor 4
T62642
Synonym:
Target:
Microtubule inhibitor 3
T62867
Synonym:
Target:
Microtubule-associated protein tau (26-44)
TP1420
Synonym:
Target:
Microtubule inhibitor 7
T62639
Synonym:
Target:
Microtubule destabilizing agent-1
T74166
Synonym:
Target:
Microtubule stabilizing agent-1
T79508
Synonym:
Target:
Auristatin F
T14349
Synonym:
Target: Microtubule Associated
Entasobulin
T15236
Synonym:
Target: Microtubule Associated
KIF18A-IN-2
T60026
Synonym:
Target: Microtubule Associated
MAP4343
T9504
Synonym:
Target: Microtubule Associated
CHM-1
T22661
Synonym:
Target: Apoptosis, Others, Microtubule Associated
Sovilnesib
T39994
Synonym: AMG650
Target: Microtubule Associated
Auristatin E
T14348
Synonym:
Target: Microtubule Associated
Myoseverin
T21632
Synonym:
Target: Others, Microtubule Associated
TN-16
T7800
Synonym:
Target: Microtubule Associated
PE859
T4077
Synonym:
Target: Beta Amyloid, Gamma-secretase, Microtubule Associated
BNC105
T14694
Synonym:
Target: Microtubule Associated
Spastazoline
T8513
Synonym:
Target: Others
SSE15206
T5699
Synonym:
Target: Apoptosis, Microtubule Associated
BRD9876
T8342
Synonym:
Target: Others, Kinesin, Microtubule Associated
ARQ 621
T6393
Synonym:
Target: Kinesin
Antiproliferative agent-13
T9974
Synonym:
Target: Dehydrogenase
Plinabulin
T2511
Synonym: NPI-2358
Target: Microtubule Associated
Parbendazole
T6071
Synonym: SKF 29044
Target: Microtubule Associated, Parasite
Lexibulin
T2090
Synonym: CYT-997
Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated
VCMMAE
T4232
Synonym: mc-vc-PAB-MMAE
Target: Microtubule Associated
Thiocolchicine
T41248
Synonym:
Target: Microtubule Associated
BTB-1
T4029
Synonym: BTB 1,NSC156750
Target: Microtubule Associated
Soblidotin
T14350
Synonym: Auristatin PE,TZT-1027
Target: Microtubule Associated
DM4
T15141
Synonym: Ravtansine
Target: Others, Microtubule Associated
Estramustine phosphate sodium
T4451
Synonym: Ro 21-8837/001,Estramustine phosphate disodium
Target: Apoptosis, Microtubule Associated
Niguldipine Free Base
T71582
Synonym:
Target:
Tirbanibulin
T6345
Synonym: KX2-391,KX-01
Target: Microtubule Associated, Src
D-64131
T1753
Synonym:
Target: Microtubule Associated
ABT-751
T1758
Synonym: E7010
Target: Microtubule Associated, Autophagy
Sertaconazole
T50005
Synonym:
Target: Antifungal
Tubulin inhibitor 24
T9812
Synonym:
Target: Microtubule Associated
Triclabendazole
T0838
Synonym: CGA89317
Target: Microtubule Associated, Parasite
MMAF
T3256
Synonym: MonoMethyl auristatin F
Target: Others, Microtubule Associated
Crolibulin
T15012
Synonym: EPC2407
Target: Microtubule Associated
Flubendazole
T0009
Synonym: Flumoxanal,Flumoxane,NSC 313680,Fluvermal
Target: Apoptosis, Microtubule Associated, Parasite
Nocodazole
T2802
Synonym: R17934,Oncodazole
Target: Apoptosis, Microtubule Associated, Bcr-Abl, Autophagy, CRISPR/Cas9
ELR510444
T2060
Synonym: LR-510444,LR510444,LR 510444
Target: Apoptosis, Microtubule Associated
Epothilone B
T6075
Synonym: Patupilone,EPO 906
Target: Apoptosis, Microtubule Associated, Antibiotic, Antifungal
LP-261
T9595
Synonym:
Target: Microtubule Associated
1 2 3 4 5 6
カタログ番号 製品名 別名 ターゲット
T36850 Curvulin Microtubule Associated
Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly.
TN2190 Scoulerine Apoptosis , Beta-Secretase , BACE , Parasite
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
T8188 Podophyllotoxone Others , Microtubule Associated
Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.
T21351 Maytansine NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine Microtubule Associated , Antibiotic
Maytansine (NSC-153858), an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
T3S0209 Vincristine ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristine can treat MM, ERK1/2, Akt, and NF-κB inhibitors are pote...
T1121 Podofilox Podophyllotoxin,(+)-Shikonin Microtubule Associated , Topoisomerase
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irrit...
T2773 Vindoline Microtubule Associated
Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.
TN2256 Taccalonolide B Microtubule Associated
Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.
TN1087 Deoxypodophyllotoxin Apoptosis , Microtubule Associated , Autophagy
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.
TN2254 Taccalonolide A Apoptosis , Microtubule Associated
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ...
T6490 Epothilone A epothile,Epo A Apoptosis , Microtubule Associated
Epothilone A (Epo A) is a microtubule-stabilizing agent with EC0.01 of 2 μM.
T2217 Cephalomannine Baccatin III Microtubule Associated
Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
T0320 Colchicine Colcin,Colchineos,Colchisol Apoptosis , Microtubule Associated , Autophagy
Colchicine (Colcin) is a natural product that is an inhibitor of microtubule polymerization (IC50=3 nM) and blocks microtubule polymerization by binding to microtubule proteins. Colchicine can be used in the treatment of...
T0968 Paclitaxel Taxol,NSC 125973 Apoptosis , Microtubule Associated , Autophagy
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
T16016 Maytansinol Ansamitocin P-0 Apoptosis , Microtubule Associated
Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.
T1668 Vinblastine sulfate NSC49842,Vincaleukoblastine sulfate salt Microtubule Associated , AChR , Autophagy
Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
T3S2372 7-epi-Taxol 7-Epitaxol,7-epi-Paclitaxel Others , Microtubule Associated
1. 7-epi-Taxol (7-Epitaxol) is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
T1034 Docetaxel NSC 628503,RP-56976 Apoptosis , Microtubule Associated , Endogenous Metabolite
Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing,...
T1270 Vincristine sulfate Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate Apoptosis , Microtubule Associated
Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle.
T19720 Colcemid C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine Microtubule Associated
Colcemid (NSC-3096) is an inhibitor of microtubule polymerization. It used to study embryonic cloning.
TP1180 Dolastatin 10 NSC 376128,DLS 10 Microtubule Associated
Dolastatin 10 (DLS 10) is a powerful peptide with antimitotic properties, effectively inhibiting tubulin polymerization.
T6212 Combretastatin A4 CA4,CRC 87-09 Microtubule Associated
Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).
T22455 Vindesine sulfate DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS Others
Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule...
T2220 2-Methoxyestradiol NSC-659853,2-MeOE2,2-ME2 Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T0186 Docetaxel trihydrate RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate Apoptosis , BCL , Microtubule Associated
T1152 Albendazole SKF-62979 HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T2937 4'-Demethylepipodophyllotoxin 4'-DMEP,4-Demethylepipodophyllotoxin,DMEP,4'-O-demethylepipodophyllotoxin Microtubule Associated
4'-Demethylepipodophyllotoxin (DMEP) is a potent inhibitor of microtubule assembly.
T2543 Cabazitaxel XRP6258,RPR-116258A,TXD 258,taxoid XRP6258 Microtubule Associated , Autophagy
Cabazitaxel (taxoid XRP6258) is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.
T5165 10-Deacetyltaxol 10-DAT,10-Desacetyl Paclitaxel,Deacetyltaxol,10-deacetyl-paclitaxel,Deacetyl Paclitaxel Others , Microtubule Associated
10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.
T6213 Vinorelbine ditartrate Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate Microtubule Associated , Autophagy
Vinorelbine ditartrate (KW-2307), a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
T6272 Fosbretabulin Disodium Combretastatin A4 Phosphate,CA 4DP,CA 4P,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium Apoptosis , Microtubule Associated
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibit...
T5749 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,10-Deacetylpaclitaxel 7-Xyloside Others , Microtubule Associated
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.
T22262 Ansamitocin p-3 Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222 Microtubule Associated
Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.
TQ0202 Epothilone D KOS 862 Microtubule Associated
Epothilone D (KOS 862) is an effective microtubule stabilizer.
T10763 Ceratamine A Others
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent with cytotoxicity against human cancer cell lines.
T75573 Taccalonolide E
Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis .
TN2299 Vindesine Others
Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms.
T10928 Cytochalasin A HIV Protease
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubu...
TQ0112 Tubulysin A TubA Microtubule Associated
Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic.
T75521 PM050489
PM050489, a potent polyketone inhibitor of Microtubule/Tubulin isolated from the Madagascan sponge Lithoplocamia lithistoides, effectively inhibits mitosis with an IC 50 value of 26.4 nM. This compound exhibits antitumor...
T72964 Dictyostatin Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin
Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule-stabilizing and anti-cancer agent that exhibits antiproliferative activity and has potential for tauopathy research.
T74761 Eleutherobin
Eleutherobin, a potent β-microtubule inhibitor with an IC50 value of 2 μM, exhibits cytotoxic activity against cancer cells at a potency comparable to Paclitaxel. This compound is derived from marine soft coral and is kn...
TN2255 Taccalonolide AJ Others
Taccalonolide AJ is a microtubule stabilizer; it has excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administr...
T2S1797 Santalol Antioxidant , Antifungal
1. Santalol has good antibacterial, anti-oxidation and anti-tumor activities. 2. α-Santalol is a potent antimitotic agent induced by interference with microtubule assembly. 3. α-Santalol shows a significant antifungal ef...
T75622 β-Apopicropodophyllin
β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage, cell cycle arrest, and ER stress. This compound holds potentia...
T73206 Wikstrol A
Wikstrol A, a potent antifungal, antimitotic, and anti-HIV-1 agent, demonstrates significant effects across various biological targets. It induces morphological deformation in P. oryzae mycelia, with a minimum morphologi...

天然物製品

Curvulin
T36850
Synonym:
Target: Microtubule Associated
Scoulerine
TN2190
Synonym:
Target: Apoptosis, Beta-Secretase, BACE, Parasite
Podophyllotoxone
T8188
Synonym:
Target: Others, Microtubule Associated
Maytansine
T21351
Synonym: NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine
Target: Microtubule Associated, Antibiotic
Vincristine
T3S0209
Synonym:
Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR
Podofilox
T1121
Synonym: Podophyllotoxin,(+)-Shikonin
Target: Microtubule Associated, Topoisomerase
Vindoline
T2773
Synonym:
Target: Microtubule Associated
Taccalonolide B
TN2256
Synonym:
Target: Microtubule Associated
Deoxypodophyllotoxin
TN1087
Synonym:
Target: Apoptosis, Microtubule Associated, Autophagy
Taccalonolide A
TN2254
Synonym:
Target: Apoptosis, Microtubule Associated
Epothilone A
T6490
Synonym: epothile,Epo A
Target: Apoptosis, Microtubule Associated
Cephalomannine
T2217
Synonym: Baccatin III
Target: Microtubule Associated
Colchicine
T0320
Synonym: Colcin,Colchineos,Colchisol
Target: Apoptosis, Microtubule Associated, Autophagy
Paclitaxel
T0968
Synonym: Taxol,NSC 125973
Target: Apoptosis, Microtubule Associated, Autophagy
Maytansinol
T16016
Synonym: Ansamitocin P-0
Target: Apoptosis, Microtubule Associated
Vinblastine sulfate
T1668
Synonym: NSC49842,Vincaleukoblastine sulfate salt
Target: Microtubule Associated, AChR, Autophagy
7-epi-Taxol
T3S2372
Synonym: 7-Epitaxol,7-epi-Paclitaxel
Target: Others, Microtubule Associated
Docetaxel
T1034
Synonym: NSC 628503,RP-56976
Target: Apoptosis, Microtubule Associated, Endogenous Metabolite
Vincristine sulfate
T1270
Synonym: Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate
Target: Apoptosis, Microtubule Associated
Colcemid
T19720
Synonym: C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine
Target: Microtubule Associated
Dolastatin 10
TP1180
Synonym: NSC 376128,DLS 10
Target: Microtubule Associated
Combretastatin A4
T6212
Synonym: CA4,CRC 87-09
Target: Microtubule Associated
Vindesine sulfate
T22455
Synonym: DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS
Target: Others
2-Methoxyestradiol
T2220
Synonym: NSC-659853,2-MeOE2,2-ME2
Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy
Docetaxel trihydrate
T0186
Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate
Target: Apoptosis, BCL, Microtubule Associated
Albendazole
T1152
Synonym: SKF-62979
Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite
4'-Demethylepipodophyllotoxin
T2937
Synonym: 4'-DMEP,4-Demethylepipodophyllotoxin,DMEP,4'-O-demethylepipodophyllotoxin
Target: Microtubule Associated
Cabazitaxel
T2543
Synonym: XRP6258,RPR-116258A,TXD 258,taxoid XRP6258
Target: Microtubule Associated, Autophagy
10-Deacetyltaxol
T5165
Synonym: 10-DAT,10-Desacetyl Paclitaxel,Deacetyltaxol,10-deacetyl-paclitaxel,Deacetyl Paclitaxel
Target: Others, Microtubule Associated
Vinorelbine ditartrate
T6213
Synonym: Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate
Target: Microtubule Associated, Autophagy
Fosbretabulin Disodium
T6272
Synonym: Combretastatin A4 Phosphate,CA 4DP,CA 4P,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium
Target: Apoptosis, Microtubule Associated
10-Deacetyl-7-xylosyl paclitaxel
T5749
Synonym: 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,10-Deacetylpaclitaxel 7-Xyloside
Target: Others, Microtubule Associated
Ansamitocin p-3
T22262
Synonym: Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222
Target: Microtubule Associated
Epothilone D
TQ0202
Synonym: KOS 862
Target: Microtubule Associated
Ceratamine A
T10763
Synonym:
Target: Others
Taccalonolide E
T75573
Synonym:
Target:
Vindesine
TN2299
Synonym:
Target: Others
Cytochalasin A
T10928
Synonym:
Target: HIV Protease
Tubulysin A
TQ0112
Synonym: TubA
Target: Microtubule Associated
PM050489
T75521
Synonym:
Target:
Dictyostatin
T72964
Synonym: Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin
Target:
Eleutherobin
T74761
Synonym:
Target:
Taccalonolide AJ
TN2255
Synonym:
Target: Others
Santalol
T2S1797
Synonym:
Target: Antioxidant, Antifungal
β-Apopicropodophyllin
T75622
Synonym:
Target:
Wikstrol A
T73206
Synonym:
Target:

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-03425 Tau Protein, Human, Recombinant (His) Human E. coli
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are...
TMPY-03340 MAP1LC3A Protein, Human, Recombinant (His) Human E. coli
LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between mic...
TMPY-03749 LC3B Protein, Human, Recombinant (His) Human E. coli
MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are in...
TMPJ-00828 Tau-F Protein, Human, Recombinant Human E. coli
Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons...
TMPY-03865 EB3 Protein, Human, Recombinant (His) Human E. coli
MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3, also known as EB3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. MAPRE3 is a member of the RP/EB family. It localizes t...
TMPJ-00827 Tau-D Protein, Human, Recombinant (His) Human E. coli
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. ...
TMPJ-01321 MAP1LC3B Protein, Human, Recombinant Human E. coli
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in t...
TMPY-04329 Vimentin Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers ...
TMPH-01254 DNM1 Protein, Human, Recombinant (His) Human E. coli
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocy...
TMPJ-01076 FKBP4 Protein, Human, Recombinant (His) Human E. coli
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone recepto...
TMPY-03047 Stathmin 1 Protein, Human, Recombinant (His) Human E. coli
Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and ...
TMPH-02944 TCTP/TPT1 Protein, Mouse, Recombinant (His) Mouse E. coli
Involved in calcium binding and microtubule stabilization. TCTP/TPT1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.5 kDa and the access...
TMPH-02138 Stathmin-4 Protein, Human, Recombinant (GST) Human E. coli
Exhibits microtubule-destabilizing activity. Stathmin-4 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 52.4 kDa and the accession number is Q...
TMPH-01592 KIF18B Protein, Human, Recombinant (His & Myc) Human E. coli
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
TMPH-01256 Dystonin Protein, Human, Recombinant (His & SUMO) Human E. coli
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and musc...
TMPH-01257 Dystonin Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and musc...
TMPH-02313 RPGR Protein, Human, Recombinant (hFc) Human HEK293 Cells
Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integ...
TMPH-03375 Stathmin-2 Protein, Rat, Recombinant (His) Rat E. coli
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from ...
TMPH-02304 Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO) Human E. coli
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito...
TMPH-01207 DOCK8 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a...
TMPH-02622 DOCK8 Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a...
TMPH-02623 DOCK8 Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a...
TMPY-04025 CEP57 Protein, Human, Recombinant (GST) Human E. coli
CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between...
TMPH-01683 Tau Protein, Human, Recombinant (HEK293, His) Human HEK293 Cells
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane com...
TMPH-00895 Human adenovirus B serotype 3 Hexon protein (His & Myc) HAdV-3 E. coli
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. ...
TMPY-02980 BLOC1S2 Protein, Human, Recombinant (GST) Human E. coli
BLOC1S2, also known as BLOS2, belongs to the BLOC1S2 family. It is a component of BLOC-1 complex. The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. The BLOC-1 co...
TMPY-03596 JTB Protein, Human, Recombinant (mFc) Human HEK293 Cells
Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JT...
TMPY-03509 TCTP/TPT1 Protein, Human, Recombinant (His) Human E. coli
Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activi...
TMPH-02846 BICD2 Protein, Mouse, Recombinant (GST) Mouse E. coli
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction...
TMPY-02718 Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST) Human E. coli
DCX (doublecortin, N-GST chimera)contains 2 doublecortin domains and belongs to the doublecortin family. It is highly expressed in neuronal cells of fetal brain, but not expressed in other fetal tissues. In the adult, it...
TMPH-01621 BRCC3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes...
TMPY-04558 NEK7 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
NIMA (never in mitosis gene a)-related kinase 7, NEK7 belongs to the NIMA subfamily, NEK Ser/Thr protein kinase family, protein kinase superfamily. NEKs (NIMA-related kinases) are mammalian serine/threonine (Ser/Thr) pro...
TMPY-04455 PKC iota Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr prote...
TMPH-02275 Lck Protein, Human, Recombinant (His) Human E. coli
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TC...
Tau Protein, Human, Recombinant (His)
TMPY-03425
Species: Human
Expression System: E. coli
MAP1LC3A Protein, Human, Recombinant (His)
TMPY-03340
Species: Human
Expression System: E. coli
LC3B Protein, Human, Recombinant (His)
TMPY-03749
Species: Human
Expression System: E. coli
Tau-F Protein, Human, Recombinant
TMPJ-00828
Species: Human
Expression System: E. coli
EB3 Protein, Human, Recombinant (His)
TMPY-03865
Species: Human
Expression System: E. coli
Tau-D Protein, Human, Recombinant (His)
TMPJ-00827
Species: Human
Expression System: E. coli
MAP1LC3B Protein, Human, Recombinant
TMPJ-01321
Species: Human
Expression System: E. coli
Vimentin Protein, Human, Recombinant (His)
TMPY-04329
Species: Human
Expression System: Baculovirus Insect Cells
DNM1 Protein, Human, Recombinant (His)
TMPH-01254
Species: Human
Expression System: E. coli
FKBP4 Protein, Human, Recombinant (His)
TMPJ-01076
Species: Human
Expression System: E. coli
Stathmin 1 Protein, Human, Recombinant (His)
TMPY-03047
Species: Human
Expression System: E. coli
TCTP/TPT1 Protein, Mouse, Recombinant (His)
TMPH-02944
Species: Mouse
Expression System: E. coli
Stathmin-4 Protein, Human, Recombinant (GST)
TMPH-02138
Species: Human
Expression System: E. coli
KIF18B Protein, Human, Recombinant (His & Myc)
TMPH-01592
Species: Human
Expression System: E. coli
Dystonin Protein, Human, Recombinant (His & SUMO)
TMPH-01256
Species: Human
Expression System: E. coli
Dystonin Protein, Human, Recombinant (His)
TMPH-01257
Species: Human
Expression System: P. pastoris (Yeast)
RPGR Protein, Human, Recombinant (hFc)
TMPH-02313
Species: Human
Expression System: HEK293 Cells
Stathmin-2 Protein, Rat, Recombinant (His)
TMPH-03375
Species: Rat
Expression System: E. coli
Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO)
TMPH-02304
Species: Human
Expression System: E. coli
DOCK8 Protein, Human, Recombinant (His)
TMPH-01207
Species: Human
Expression System: P. pastoris (Yeast)
DOCK8 Protein, Mouse, Recombinant (E. coli, His)
TMPH-02622
Species: Mouse
Expression System: E. coli
DOCK8 Protein, Mouse, Recombinant (His)
TMPH-02623
Species: Mouse
Expression System: P. pastoris (Yeast)
CEP57 Protein, Human, Recombinant (GST)
TMPY-04025
Species: Human
Expression System: E. coli
Tau Protein, Human, Recombinant (HEK293, His)
TMPH-01683
Species: Human
Expression System: HEK293 Cells
Human adenovirus B serotype 3 Hexon protein (His & Myc)
TMPH-00895
Species: HAdV-3
Expression System: E. coli
BLOC1S2 Protein, Human, Recombinant (GST)
TMPY-02980
Species: Human
Expression System: E. coli
JTB Protein, Human, Recombinant (mFc)
TMPY-03596
Species: Human
Expression System: HEK293 Cells
TCTP/TPT1 Protein, Human, Recombinant (His)
TMPY-03509
Species: Human
Expression System: E. coli
BICD2 Protein, Mouse, Recombinant (GST)
TMPH-02846
Species: Mouse
Expression System: E. coli
Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST)
TMPY-02718
Species: Human
Expression System: E. coli
BRCC3 Protein, Human, Recombinant (His & SUMO)
TMPH-01621
Species: Human
Expression System: E. coli
NEK7 Protein, Human, Recombinant (His & GST)
TMPY-04558
Species: Human
Expression System: Baculovirus Insect Cells
PKC iota Protein, Human, Recombinant (GST)
TMPY-04455
Species: Human
Expression System: Baculovirus Insect Cells
Lck Protein, Human, Recombinant (His)
TMPH-02275
Species: Human
Expression System: E. coli
カタログ番号 製品名
L1110 Microtubule-Targeted Compound Library

142 compounds
A unique collection of 142 microtubule-targeted compounds can be used in HTS and HCS;
L1310 Cytoskeletal Signaling Pathway Compound Library

759 compounds
A unique collection of 759 cytoskeleton-related compounds, can be used for HTS and HCS;