Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 12,000 | |||
10 mg | 在庫あり | ¥ 18,500 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | ¥ 53,000 | |||
100 mg | 在庫あり | ¥ 69,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,000 |
説明 | TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1. |
ターゲット&IC50 | UCHL3:0.6 μM |
In vitro | TCID is selective for UCH-L3 over UCH-L1 by over 100-fold. [1] NU6027 (10 μM) does not promote YFP-GLT-1 accumulation in intracellular vesicles in transfected MDCK cells, while LDN-57444 (10 μM) promotes YFP-GLT-1 accumulation. NU6027 (10 μM) does not produce long-term lysosomal degradation of GLT-1, while LDN-57444 (10 μM) has such effect. [2] TCID (10 μM) diminishes GlyT2 ubiquitination in brainstem and spinal cord primary neurons, which is more pronounced when UCHL1 is inhibited and when cells are exposed to these inhibitors for longer periods. [3] |
別名 | UCH-L3 Inhibitor |
分子量 | 283.92 |
分子式 | C9H2Cl4O2 |
CAS No. | 30675-13-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 14.2 mg/mL (50 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TCID 30675-13-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB hydrolase C-terminal Neuronal Deubiquitinase transporter UCH-L3 Inhibitor ubiquitination DUBs inhibit glycine ubiquitin UCH-L3 UCH-L1 GlyT2 Inhibitor inhibitor