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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T13244 | Ubiquitination-IN-1 | Others | |
T75030 | Ubiquitination-IN-2 | ||
Ubiquitination-IN-2 is a potent inhibitor of E1-E2 protein−protein interactions (PPI), displaying inhibitory activity with a dissociation constant (Kd) of 0.72 μM for the ubiquitin E1 (Uba1) enzyme. By blocking the trans... | |||
T21773 | SP-141 | SP 141 | Mdm2 |
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. | |||
T8773 | MID-1 | Others , IGF-1R | |
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skelet... | |||
T2026 | CYM5442 | S1P Receptor , LPL Receptor | |
CYM5442 is an S1P agonist, targeting to Sphingosine. | |||
T6697 | TCID | UCH-L3 Inhibitor | DUB |
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1. | |||
T1862 | PR-619 | PR 619,2,6-Diamino-3,5-dithiocyanopyridine | Apoptosis , DUB , Autophagy |
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs). | |||
T9758 | DCeMM3 | 2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide | Others |
dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradati... | |||
T25465 | GS143 | GS-143,GS 143 | IκB/IKK , E1/E2/E3 Enzyme , NF-κB |
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea... | |||
T8931L | ICCB-19 hydrochloride | ICCB-19 HCl(750621-52-4 free base) | Apoptosis , Others , Autophagy , RIP kinase |
ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal dom... | |||
T17187 | TZ9 | Apoptosis , E1/E2/E3 Enzyme | |
TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis. | |||
T1919 | Tenovin-1 | Tenovin 1 | Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy |
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. | |||
T37042 | SCH529074 | SCH 529074 | p53 |
SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. | |||
T61477 | DCeMM2 | Molecular Glues | |
dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K. | |||
T36682 | USP30 inhibitor 18 | DUB | |
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o... | |||
T64339 | Apcin A HCL | APC | |
Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to... | |||
T73560 | I-138 | DUB | |
I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells. | |||
T16904 | Smurf1-IN-A01 | A01 | Others |
Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. | |||
T17879 | E3 ligase Ligand 8 | Others , Ligand for E3 Ligase | |
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoti... | |||
T22263 | Bavdegalutamide | ARV-110 | Androgen Receptor |
Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR). Bavdegalutamide can be used in studies about prostate cancer. Bavdegalutamide shows oral activity and selectivity and facilitates the ubiquitinati... | |||
T8488 | GMB-475 | Bcr-Abl | |
GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitinati... | |||
T16974 | TAK-243 | MLN7243 | Apoptosis , E1/E2/E3 Enzyme , NF-κB |
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exh... | |||
T79133 | UC-764864 | E1/E2/E3 Enzyme | |
UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in leukemic cells. It effectively hinders the ubiquitination of sub... | |||
T67834 | C004019 | Microtubule Associated , PROTACs | |
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C... | |||
T3317 | SZL P1-41 | Apoptosis , Others , E1/E2/E3 Enzyme | |
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate... | |||
T14896 | CC0651 | Others | |
CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently inhibits the ubiquitination of p27Kip1 (IC50: 1.72 μM). | |||
T31834 | FMHM | ||
FMHM is a TRAF6 scavenging agent via ubiquitination-dependent mode. | |||
T25889 | NSC-689857 | NSC 689857,NSC689857 | |
NSC-689857 is an inhibitor that acts in the Skp2-Cks1 protein-protein interaction and p27Kip1 ubiquitination in vitro. | |||
T25738 | Linichlorin A | Elegin | |
Linichlorin A is used as a p27(Kip1) ubiquitination inhibitor. | |||
T70902 | AQ-101 | ||
AQ-101 is a inhibitor of MDM2, which induces MDM2 protein degradation through a self-ubiquitination and proteasome-mediated mechanism. | |||
T69977 | BC-1485 | ||
BC-1485 is a first-in-class inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1 ), which disrupts FIEL1-directed PIAS4 ubiquitination. | |||
T80686 | γ-AA peptide P6 | ||
γ-AA peptide P6 acts as a potent activator of E6 associated protein (E6AP), facilitating both its self-ubiquitination and the ubiquitination of E6AP substrates in vitro reconstituted reactions. Furthermore, γ-AA peptide ... | |||
T10345 | Apcin-A | Others | |
Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V. | |||
T34168 | PROTAC-I | PROTAC I | |
PROTAC-I targets steroid hormone receptors for ubiquitination and degradation. | |||
T69701 | HS-152 | ||
HS-152 is a novel reversible inhibitor of smurf1, directly targeting the catalytic activity of smurf hect domains, significantly blocking auto-ubiquitination and the transfer of ubiquitin from hect domain to the substr... | |||
T27213 | DSHN | ||
DSHN is a small heterodimer partner (SHP) activator. DSHN transcriptionally activates SHP mRNA, and stabilizes the SHP protein by preventing its ubiquitination and degradation. | |||
T10875 | CP5V | Others | |
CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. | |||
T17868 | E3 ligase Ligand 10 | Others | |
E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated d... | |||
T11975 | PROTAC Mcl1 degrader-1 | BCL | |
PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 ... | |||
T17872 | E3 ligase Ligand 14 | Others | |
E3 ligase Ligand 14 is a ligand that binds to E3 ubiquitin ligase and can be conjugated to a protein ligand via a linker to create PROTACs. These PROTACs are capable of promoting ubiquitination-mediated degradation of ca... | |||
T17871 | E3 ligase Ligand 13 | Others | |
E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degrad... | |||
T82632 | Cys-C-cGMP | AUTACs | |
Cys-C-cGMP serves as an autophagy tag for AUTACs (autophagy-targeting chimeras). It enhances K63-linked ubiquitination of mitochondria within HeLa cells [1]. | |||
T17876 | E3 ligase Ligand 18 | Others | |
E3 ligase Ligand 18 is a ligand that binds to E3 ubiquitin ligase, and it can be chemically attached to a protein ligand through a linker to create PROTACs. The resulting PROTACs function as inducers of ubiquitination-me... | |||
T17363 | β-Naphthoflavone-CH2-OH | β-NF-CH2-OH | Others |
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1). These... | |||
T17880 | E3 ligase Ligand 9 | Others | |
E3 ligase Ligand 9 is a compound that serves as a ligand for E3 ubiquitin ligase. It can be linked to the protein ligand through a linker, forming PROTACs or SNIPERs. These PROTACs are known to induce the degradation of ... | |||
T37646 | HB007 | ||
HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for in... | |||
T75125 | ITK degrader 2 | ||
ITK Degrader 2 (Compound 30) functions as a modulator for targeted ubiquitination and serves as a molecule for targeted protein degradation, specifically degrading ITK [1]. | |||
T61776 | TEAD-IN-2 | ||
TEAD-IN-2 is an innovative, orally bioavailable inhibitor that targets the transcriptional enhancer associate domain (TEAD). It functions by regulating TEAD through ubiquitination and/or degradation by specific compounds... | |||
T61057 | DCeMM4 | ||
dCeMM4 (Compound 5) is a glue degrader that induces cyclin K ubiquitination and degradation through prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex [1]. | |||
T70096 | AEG40730 HCl | ||
AEG40730 is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG40730 binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in R... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T4970 | LANOSTEROL | 3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol | Endogenous Metabolite |
Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived. | |||
T2140 | Parthenolide | (-)-Parthenolide | Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy |
(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions. | |||
T6S1780 | Protosappanin B | Q-100961,FT-0689654 | Apoptosis |
1. Protosappanin B (Q-100961) significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, vi... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-02521 | HIST3H2A Protein, Human, Recombinant | Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ... | |||
TMPJ-01403 | UBE2D4 Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational... | |||
TMPH-03391 | TRIM2 Protein, Rat, Recombinant (His) | Rat | E. coli |
E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ische... | |||
TMPH-01259 | AMFR Protein, Human, Recombinant (His) | Human | E. coli |
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC... | |||
TMPH-01260 | AMFR Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC... | |||
TMPH-02136 | SPSB1 Protein, Human, Recombinant (His) | Human | E. coli |
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Nega... | |||
TMPH-01273 | TRIP12 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein a... | |||
TMPJ-00571 | UBE2D3 Protein, Human, Recombinant | Human | E. coli |
UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubi... | |||
TMPH-02651 | Fbxo3 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and ... | |||
TMPH-01267 | RNF13 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein... | |||
TMPY-02605 | UBE2F Protein, Human, Recombinant (His) | Human | E. coli |
UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ... | |||
TMPH-02847 | CNPY2 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. | |||
TMPH-02633 | TRIM21 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of... | |||
TMPY-02950 | WWP2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thio... | |||
TMPH-01288 | Elongin-B Protein, Human, Recombinant (GST) | Human | E. coli |
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its... | |||
TMPY-02604 | UBE2D4 Protein, Human, Recombinant (His) | Human | E. coli |
UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed... | |||
TMPJ-00999 | UBE2D1 Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes... | |||
TMPH-01650 | PRAME Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination a... | |||
TMPY-03505 | COMMD9 Protein, Human, Recombinant (His) | Human | E. coli |
COMMD9 is a COMM domain-containing or COMMD protein. COMMD family is comprised of ten members which are widely conserved throughout evolution and share certain functional properties. They represent a recently discover... | |||
TMPH-01203 | DCAF16 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. DCAF16 Protein, Human, Recombinant... | |||
TMPY-02608 | UBC9/UBE2I Protein, Human, Recombinant | Human | E. coli |
UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ... | |||
TMPY-02609 | UBE2M Protein, Human, Recombinant | Human | E. coli |
UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ... | |||
TMPY-02607 | Ube2H Protein, Human, Recombinant | Human | E. coli |
UBE2H is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ... | |||
TMPY-02606 | UBE2G1 Protein, Human, Recombinant | Human | E. coli |
UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed... | |||
TMPH-03074 | UBC5A Protein, Japonica rice, Recombinant (His & Myc) | Rice | E. coli |
E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins. UBC5A Protein, Japonica rice, Recombinant (His & Myc) is expressed in E. coli expression syste... | |||
TMPH-02632 | TRIM21 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of... | |||
TMPH-02233 | P4HTM Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic... | |||
TMPH-02131 | SKP2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle pr... | |||
TMPH-02208 | TRAF3 Protein, Human, Recombinant | Human | E. coli |
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon.... | |||
TMPH-01220 | DDA1 Protein, Human, Recombinant (His) | Human | E. coli |
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, ... | |||
TMPH-03508 | IpaH9.8 Protein, Shigella flexneri, Recombinant (His) | Shigella flexneri | P. pastoris (Yeast) |
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute i... | |||
TMPY-00361 | Pellino-1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant ce... | |||
TMPY-03394 | RYBP Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
APAP-1, also known as AAP1 and RYBP, is widely expressed. It is highest expressed in lymphoid tissues and placenta. APAP-1 contains 1 RanBP2-type zinc finger. It may bind to DNA. APAP-1 inhibits ubiquitination and subseq... | |||
TMPY-02842 | UBE2L6 Protein, Human, Recombinant (His) | Human | E. coli |
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain.... | |||
TMPH-01270 | TRAIP Protein, Human, Recombinant (His) | Human | E. coli |
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe... | |||
TMPY-02642 | UBE2W Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important c... | |||
TMPH-03282 | TRIM63 Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein... | |||
TMPH-01274 | ZNRF3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both can... | |||
TMPH-01275 | ZNRF3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both can... | |||
TMPH-01952 | SPRY2 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgro... | |||
TMPJ-01138 | UBE2S Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activat... | |||
TMPJ-01047 | UBE2H Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived protei... | |||
TMPJ-00985 | UBE2A Protein, Human, Recombinant (GST, His) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived prot... | |||
TMPJ-01362 | UBAP1 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-Associated Protein 1 (UBAP1) belongs to the UBA domain family. Members of this family are related to ubiquitin and the ubiquitination pathway. Because of their cytogenetic location, this UBA domain family membe... | |||
TMPJ-01249 | ASB13 Protein, Human, Recombinant (His) | Human | E. coli |
Ankyrin repeat and SOCS box protein 13(ASB13) is a member of the ankyrin repeat and SOCS box-containing (ASB) family. ASB13 contain six ankyrin repeats sequence and a SOCS box domain. The SOCS box serves to couple suppre... | |||
TMPH-02126 | SORBS2 Protein, Human, Recombinant (His) | Human | E. coli |
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of AB... | |||
TMPH-01271 | TRIM63 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein... | |||
TMPJ-01324 | UBA5 Protein, Human, Recombinant (His) | Human | E. coli |
UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. T... | |||
TMPH-02634 | TRIM63 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein... | |||
TMPY-03440 | Sts1 Protein, Human, Recombinant (His) | Human | E. coli |
UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of ep... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L8600 | Ubiquitination Compound Library | 210 compounds | |
A unique collection of 210 ubiquitination related small chemicals can be used for high throughput and high content screening; | |||
L8500 | HIF-1 Signaling Pathway Compound Library | 1336 compounds | |
A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; | |||
L3800 | NF-κB Signaling Compound Library | 729 compounds | |
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening; |