Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 29,000 | |||
10 mg | 在庫あり | ¥ 38,000 | |||
25 mg | 在庫あり | ¥ 66,000 | |||
50 mg | 在庫あり | ¥ 103,500 | |||
100 mg | 在庫あり | ¥ 152,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 38,000 |
説明 | TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes. |
In vivo | TM38837, a novel, largely peripherally restricted CB1 antagonist, in terms of fear-promoting consequences of systemic vs. intracerebral injections.?Different groups of male C57BL/6 N mice underwent auditory fear conditioning, followed by re-exposure to the tone.?Mice were treated per os (p.o.) with TM38837 (10, 30, or 100 mg/kg), rimonabant (10 mg/kg;?a brain penetrating CB1 antagonist/inverse agonist which served as a positive control), or vehicle, 2 h prior the tone presentation.?Only the high dose of TM38837 (100 mg/kg) induced a significant increase in freezing behavior, similar to that induced by rimonabant (10 mg/kg) (p |
分子量 | 617.51 |
分子式 | C30H25Cl2F3N4OS |
CAS No. | 1253641-65-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (64.77 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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TM38837 1253641-65-4 GPCR/G Protein Cannabinoid Receptor peripheral CB1 TM-38837 antiobesity TM 38837 inhibit fat Inhibitor metabolic fear inhibitor