Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)
説明 | Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.) |
ターゲット&IC50 | PI3Kγ:33 nM, PI3Kδ:25 nM |
In vitro | In both HEL-RS and HEL-RR cells, Tenalisib exhibits modest proliferation inhibition (33-46% inhibition @ 10 μM). Addition of 10 μM tenalisib to ruxolitinib is synergistic resulting in a near-complete inhibition of proliferation (>90% for HEL-RS and >70% for HEL-RR). Addition of 5 μM tenalisib, 4 h prior to the addition of ruxolitinib results in a significant reduction in EC50of ruxolitinib (5.8 μM) in HEL-RR cells. |
In vivo | Single agent(Tenalisib) activity is evident in difficult-to-treat subjects at ≥ 200 mg BID[2]. |
別名 | RP6530 |
分子量 | 415.42 |
分子式 | C23H18FN5O2 |
CAS No. | 1639417-53-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (240.72 mM)
You can also refer to dose conversion for different animals. 詳細
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Tenalisib 1639417-53-0 PI3K/Akt/mTOR signaling PI3K RP-6530 RP6530 Phosphoinositide 3-kinase Inhibitor RP 6530 inhibit inhibitor