Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .
説明 | Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . |
ターゲット&IC50 | SIRT1:21 μM, SIRT3:67 μM, SIRT2:10 μM |
In vitro | Inhibition of SIRT1/2 by Tenovin-6 induced apoptosis in UM cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ROS).?Tenovin-6 inhibited the growth of UM cells.?Tenovin-6 and vinblastine was synergistic in inducing apoptosis of UM cell line 92.1 and Mel 270.?Furthermore, Tenovin-6 eliminated cancer stem cells in 92.1 and Mel 270 cells.?In conclusion, our findings suggest that Tenovin-6 may be a promising agent to kill UM bulk tumor cells and CSCs[1].tenovin-6 increases microtubule-associated protein 1 light chain 3 (LC3-II) level in diverse cell types in a time- and dose-dependent manner. Mechanistically, the increase of LC3-II by tenovin-6 is caused by inhibition of the classical autophagy pathway via impairing lysosomal function without affecting the fusion between autophagosomes and lysosomes.tenovin-6 activation of p53 is cell type dependent, and tenovin-6 inhibition of autophagy is not dependent on its regulatory functions on p53 and SIRT1[2]. |
分子量 | 491.09 |
分子式 | C25H35ClN4O2S |
CAS No. | 1011301-29-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (91.63 mM)
You can also refer to dose conversion for different animals. 詳細
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Tenovin-6 Hydrochloride 1011301-29-3 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism p53 HDAC Dehydrogenase Sirtuin acetylation Dihydroorotate Dehydrogenase protein-deacetylating Tenovin 6 Hydrochloride DHODH Tenovin 6 Inhibitor degradation Tenovin6 Tenovin6 Hydrochloride inhibit MDM2 MDM-2/p53 Tenovin-6 inhibitor