Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 31,000 | |||
5 mg | 在庫あり | ¥ 66,500 | |||
10 mg | 在庫あり | ¥ 110,000 | |||
25 mg | 在庫あり | ¥ 181,000 | |||
50 mg | 在庫あり | ¥ 248,000 | |||
100 mg | 在庫あり | ¥ 340,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 73,000 |
説明 | Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research. |
In vitro | Teplinovivint (5.8, 10.8, 21.7, 41.7, 83.3, 166.6, 333.3, 750 nM) induced the expression of SCXA, TenacinC and Tenomodulin, in a dose-dependent manner with an EC50 between 139-189 nM. Teplinovivint (compound 175; 0.0003-10 μM) inhibits Wnt/p-catenin activity in human colorectal cancecell line (SW480) in a dose-dependent manner (EC50=152.9 nM). Teplinovivint inhibits SW480 cells (EC50=25 nM) and primary human mesenchymal stem cells (hMSCs; EC50=10.377 μM). |
In vivo | Teplinovivint (1 mg/ml with 1% BA) has a Tmax of 1 hours in plasma. ?Teplinovivint (10 mg/ml;?once daily for 21 days via topical application) causes amelioration of inflammation as well as tendon degeneration.?Teplinovivint results in a decrease of aninflammatory plasma biomarker, KC/GRO in the Collagenase-induced Tendon Injury Model. |
分子量 | 442.51 |
分子式 | C25H26N6O2 |
CAS No. | 1428064-91-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (188.31 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Teplinovivint 1428064-91-8 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin inhibit Inhibitor stem Tenomodulin SW480 β-catenin mesenchymal hMSCs colorectal SCXA TenacinC Wnt Beta catenin inhibitor