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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T9696 | β-catenin-IN-2 | Wnt/beta-catenin | |
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research. | |||
T9988 | Wnt/β-catenin agonist 3 | Wnt/beta-catenin | |
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist. | |||
T67884 | β-catenin modulator IIa-661 | Wnt/beta-catenin | |
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity. | |||
TP1730L | β-catenin peptide acetate(265669-37-2 free base) | Others | |
β-catenin peptide(βCATp) acetate is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes. | |||
T41094 | Wnt/β-catenin agonist 2 | GSK-3 , Wnt/beta-catenin | |
Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva... | |||
T39200 | β-catenin-IN-37 | ||
β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of... | |||
T60803 | Wnt/β-catenin agonist 4 | Wnt/beta-catenin | |
Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling. | |||
TP1730 | β-catenin peptide | ||
β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes. | |||
T6868 | KYA1797K | Wnt/beta-catenin | |
KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay. | |||
T12537 | β-catenin/CBP-IN-1 | Wnt/beta-catenin | |
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin | |||
T8400 | Pamidronic acid | Wnt/beta-catenin | |
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells | |||
T13344 | Wnt/β-catenin agonist 1 | Others | |
Wnt/β-catenin agonist 1 is an agonist of Wnt/β-catenin signalling pathway(EC50 of 0.27 μM). | |||
T8710 | MSAB | Wnt/beta-catenin | |
MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. | |||
T6989 | SKL2001 | Wnt/beta-catenin | |
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction. | |||
T15137 | DK419 | Wnt/beta-catenin , AMPK | |
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK. | |||
T6113 | ICG-001 | Apoptosis , Epigenetic Reader Domain , Wnt/beta-catenin | |
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. | |||
T9182 | NRX-252262 | Others , Wnt/beta-catenin | |
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM) | |||
T1971 | WAY-262611 | Wnt/beta-catenin | |
WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay. | |||
T15677 | KY1220 | Wnt/beta-catenin | |
KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells. | |||
T9151 | Teplinovivint | Wnt/beta-catenin | |
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research. | |||
T7399 | LF3 | Wnt/beta-catenin | |
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM) | |||
T21685 | CCT 031374 hydrobromide | Wnt/beta-catenin | |
CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities. | |||
T2413 | FH535 | Wnt/beta-catenin , PPAR | |
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities. | |||
T7204 | PNU-74654 | Apoptosis , Wnt/beta-catenin | |
PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. | |||
T3635 | IQ 1 | IQ1,IQ-1 | Wnt/beta-catenin |
IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on. | |||
T5642 | Tegatrabetan | BC2059 | Wnt/beta-catenin |
Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity. | |||
T2161 | Cardiogenol C | Wnt/beta-catenin | |
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells. | |||
T3062 | WIKI4 | PARP , Wnt/beta-catenin | |
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2). | |||
T10904 | CWP232228 | Wnt/beta-catenin | |
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t... | |||
T17142 | Toxoflavin | Xanthothricin,PKF-118-310,Toxoflavine | Wnt/beta-catenin , Antibacterial , Antibiotic |
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A. | |||
T0470 | Nefopam hydrochloride | Fenazoxine hydrochloride,Nefopam HCl | Wnt/beta-catenin , Sodium Channel |
Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity. | |||
T22884 | JW 67 | Wnt/beta-catenin | |
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1. | |||
T72829 | β-catenin-IN-4 | ||
β-Catenin-IN-4 is a β-catenin inhibitor characterized by a K_i value of 0.64 μM. This compound effectively lowers the protein expression levels of cyclin D1 and c-Myc. | |||
T78919 | β-catenin-IN-7 | ||
β-Catenin-IN-7 (Compound 9) is an inhibitor of β-catenin that disrupts its interaction with Tcf-4, consequently impeding Wnt-dependent gene expression, and exhibits anticancer activity [1]. | |||
T79102 | β-Catenin modulator-3 | ||
β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole-based chemical entity, serves as a potent and selective modulator of β-Catenin [1]. | |||
T1878 | XAV-939 | XAV939,NVP-XAV939 | PARP , Wnt/beta-catenin |
XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription. | |||
T79100 | β-Catenin modulator-1 | ||
β-Catenin modulator-1 (IIa-650) is a useful agent in cancer research for modulating β-Catenin [1]. | |||
T79104 | β-Catenin modulator-5 | ||
β-Catenin Modulator-5 (Compound IIa-84), an oxazole and thiazole-based compound, serves as a potent and selective modulator of β-Catenin [1]. | |||
T79101 | β-Catenin modulator-2 | ||
β-Catenin Modulator-2 (Compound IIa-130), which is an oxazole-thiazole derivative, serves as a potent and selective modulator of β-Catenin [1]. | |||
T63212 | β-catenin-IN-3 | ||
β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces the viability of β-catenin-driven cancer cells. | |||
T78120 | β-catenin-IN-6 | ||
β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and demonstrating efficacy in a β-catenin/RK3E mouse model [1] [2]. | |||
T79103 | β-Catenin modulator-4 | ||
β-Catenin modulator-4 (compound IIa-92), encompassing oxazole and thiazole moieties, acts as a potent and selective modulator of β-Catenin [1]. | |||
T16079 | Mirodenafil | SK3530 | PDE |
Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. | |||
T2310 | CHIR-99021 | Laduviglusib,CT99021,CHIR-99021 | GSK-3 , Wnt/beta-catenin , Autophagy |
CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in... | |||
T11284 | FIDAS-3 | Others , Wnt/beta-catenin , Methionine Adenosyltransferase (MAT) | |
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for ... | |||
T82235 | HCA/Wnt/β-catenin-IN-1 | ||
hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8 nM, respectively. Additionally, this compound attenuates P-g... | |||
T8005 | Cardiogenol C hydrochloride | Cardiogenol C HCl,Cardiogenol C | Wnt/beta-catenin |
Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). | |||
T39341 | FCPR03 | PDE | |
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr... | |||
T10606 | BRD0705 | GSK-3 | |
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM). | |||
T11571 | HLY78 | 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine | Wnt/beta-catenin |
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T5729 | L-quebrachitol | Wnt/beta-catenin | |
L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway. | |||
T3925 | Astragaloside I | Cyclosieversioside B,Astrasieversianin IV | Wnt/beta-catenin |
Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus membranaceus. It can stimulate osteoblast differentiation through the Wnt/β-catenin signaling pathway and can be used to study osteogen... | |||
TN1079 | Deoxyelephantopin | NF-κB | |
Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling | |||
T5679 | (E)-Ferulic acid | trans-Ferulic acid,(E)-Coniferic acid | BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite |
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr... | |||
TN1413 | Atranorin | Endogenous Metabolite , NO Synthase , Ras | |
Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotectiv... | |||
T5S1058 | Triptonide | PG 492,NSC 165677 | Apoptosis , Wnt/beta-catenin , Autophagy |
1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, an... | |||
TN7036 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14 | Wnt/beta-catenin |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa... | |||
TQ0215 | Salinomycin sodium salt | Sodium salinomycin,Salinomycin sodium | Apoptosis , Wnt/beta-catenin , Antibacterial , Antibiotic , Autophagy |
TN6508 | Trachelogenin | (-)-Trachelogenin | Virus Protease , c-Myc , HCV Protease , Wnt/beta-catenin |
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Cateni... | |||
TL0008 | Gigantol | Wnt/beta-catenin , Glucosidase | |
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a... | |||
T8229 | 5,7,3',4'-Tetramethoxyflavone | Antibacterial , Parasite , Antifungal | |
5,7,3',4'-Tetramethoxyflavone (TMF), a prominent polymethoxyflavone (PMF) derived from M. exotica, displays a range of notable bioactivities. These include anti-malarial, anti-fungal, anti-mycobacterial, and anti-inflamm... | |||
T3330 | Trans-Trimethoxyresveratrol | trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene | Reactive Oxygen Species |
trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchy... | |||
T0906 | Salinomycin | Procoxacin | Wnt/beta-catenin , Antibacterial |
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria. It acts as a potent inhibitor of Wnt/β-catenin signaling, blocking Wnt-induced LRP6 phosph... | |||
TL0007 | Bisdemethoxycurcumin | Curcumin III,Didemethoxycurcumin | Epigenetic Reader Domain , Wnt/beta-catenin |
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by mac... | |||
T4S1796 | Heterophyllin B | PI3K | |
Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa... | |||
T2818 | Methyl Vanillate | Reactive Oxygen Species , Wnt/beta-catenin , Endogenous Metabolite | |
Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. Methyl vanillate is considered to be a slightl... | |||
T3391 | Corosolic acid | Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid | FAK , Autophagy |
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by induci... | |||
TN1103 | Diphyllin | ATPase , Proton pump , Influenza Virus , HIV Protease | |
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. | |||
T4S1943 | Kirenol | Kirel | Wnt/beta-catenin |
1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid... | |||
T2771 | Orcinol glucoside | Sakakin | Antioxidant |
Orcinol glucoside (Sakakin) (OG), an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn, shows potent antioxidative and anxiolytic activities without sedative effects. | |||
T3S0153 | Xanthatin | Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial | |
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr... | |||
T3803 | Specnuezhenide | Nuzhenide,Nuezhenide | Others , NF-κB , Wnt/beta-catenin |
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t... | |||
T1716 | Echinacoside | Reactive Oxygen Species , Wnt/beta-catenin | |
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, nitric oxide radical-scavenging and vasodilat... | |||
T5S0754 | Isoquercetin | 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside | NF-κB , Wnt/beta-catenin , NO Synthase |
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in ... | |||
T23645 | Aeroplysinin 1 | NSC170364,Aeroplysinin I,NSC 170364,NSC-170364 | |
Aeroplysinin I is an antibacterial compound from the sponge. It has cytotoxic activity against colon cancer cells by promoting β-catenin degradation. | |||
T1033L | Monensin | Elancoban,Rumensin | |
Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with d... | |||
TN2371 | Isoliquiritin | Neoisoliquiritin | Others |
Neoisoliquiritigenin, isolated from Spatholobus suberectus, inhibits cell proliferation and induces cell apoptosis in breast cancer by directly binding to GRP78 to regulate the β-catenin pathway | |||
T40643 | Prodigiosin hydrochloride | Prodigiosine hydrochloride | |
Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this ... | |||
TN3468 | Atractylochromene | Wnt/beta-catenin | |
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer. | |||
T75621 | Secalonic acid D | ||
Secalonic acid D, a toxic compound effective against tumor cells, is derived from the metabolites of Aspergillus aculeatus. It operates by activating GSK3-β and degrading β-catenin, consequently down-regulating c-Myc exp... | |||
TN2775 | 2-Methoxystypandrone | MMP , BCL , IκB/IKK , GSK-3 , TNF , NOS , NF-κB , Wnt/beta-catenin , COX , JAK , STAT | |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrit... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-02205 | Beta-Catenin Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p... | |||
TMPY-02985 | Beta-Catenin Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p... | |||
TMPK-00158 | DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. | |||
TMPK-00156 | DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi) | Human | HEK293 |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. | |||
TMPK-00744 | LRP-6 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte ... | |||
TMPK-01001 | RNF43 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 i... | |||
TMPK-00155 | DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi) | Human | HEK293 |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. | |||
TMPK-00157 | DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. | |||
TMPK-01106 | Kremen-2 Protein, Human, Recombinant (His) | Human | HEK293 |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi... | |||
TMPK-01304 | Kremen-2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi... | |||
TMPK-01093 | Kremen-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi... | |||
TMPK-00743 | LGR-5 Protein, Human, Recombinant (hFc) | Human | HEK293 |
G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker... | |||
TMPK-00926 | Noggin/NOG Protein, Mouse, Recombinant (His & Flag) | Mouse | HEK293 |
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer G... | |||
TMPK-00925 | Noggin/NOG Protein, Mouse, Recombinant | Mouse | HEK293 |
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer G... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L2194 | Anti-Colorectal Cancer Compound Library | 1565 compounds | |
1565 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening. | |||
L7700 | Neural Regeneration Compound Library | 529 compounds | |
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening; | |||
L7900 | Osteogenesis Compound Library | 320 compounds | |
A unique collection of 320 osteogenesis related compounds for high throughput and high content screening; |