Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 10,000 | |||
50 mg | 在庫あり | ¥ 12,500 | |||
100 mg | 在庫あり | ¥ 21,500 | |||
200 mg | 在庫あり | ¥ 39,000 | |||
500 mg | お問い合わせ | ¥ 91,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 7,000 |
説明 | Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor |
ターゲット&IC50 | EGFR:460 μM, PDGFR:0.5 μM |
In vivo | SF 6847 prevents the PDGF-induced tyrosine phosphorylation of LGF in caveolae of human fibroblasts, suggesting that PDGF-BB-mediated activation of LRP requires tyrosine phosphorylation and thereby activates PDGFR-β. Additionally, SF 6847 inhibits the replication of Herpes Simplex Virus Type 1 (HSV-1) with an IC50 of 40 nM and enhances the inclusion of MAPT exon 10 in SHSY-5Y cells by twofold at a concentration of 1.6 μM. At 1 mM, it blocks the strain-induced stimulation of DNA synthesis in fetal lung cells. SF 6847 partially reverses vanadate-induced HSV-1 plaque formation at 50 nM and reduces viral phosphoprotein phosphorylation in a dose-dependent manner at concentrations below 400 nM. However, the reduction in protein synthesis induced by SF 6847 at concentrations below 800 nM is not dose-dependent. |
別名 | Malonoben, Tyrphostin 9, SF 6847, AG 17, RG-50872 |
分子量 | 282.38 |
分子式 | C18H22N2O |
CAS No. | 10537-47-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 21.2 mg/mL (75 mM)
You can also refer to dose conversion for different animals. 詳細
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Tyrphostin A9 10537-47-0 Angiogenesis JAK/STAT signaling Microbiology/Virology Tyrosine Kinase/Adaptors Influenza Virus EGFR VEGFR PDGFR Malonoben Tyrphostin A-9 Tyrphostin-9 Tyrphostin 9 Tyrphostin9 RG50872 inhibit Platelet-derived growth factor receptor Vascular endothelial growth factor receptor SF 6847 AG 17 AG17 SF6847 Inhibitor AG-17 Tyrphostin A 9 SF-6847 RG 50872 RG-50872 inhibitor