Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
説明 | Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases. |
ターゲット&IC50 | CCR9:10 nM |
In vitro | Vercirnon is also a potent inhibitor of CCL25-induced Molt-4 chemotaxis (IC50: 3.5 ± 0.3 nM). Vercirnon inhibits CCL25-induced calcium mobilization (IC50: 5.4 ± 0.7 nM). Vercirnon inhibits the chemotaxis of Baf-3/CCR9A cells as well as Baf-3/CCR9A cells (IC50s: 2.8 ± 1.1 nM and 2.6 ± 0.7 nM, respectively). Vercirnon potently inhibits CCL25-induced chemotaxis (IC50: 6.8 ± 1.7 nM in the buffer) and exhibits inhibition on RA-cultured cell CCL25-medidated chemotaxis in 100% human AB serum (IC50: 141 ± 13 nM). Vercirnon shows inhibitory activity against Molt-4 migration (IC50: 33.4 ± 1.3 nM in 100% human AB serum). Vercirnon suppresses the binding of [3H] CCX807 to Molt-4 cells (IC50: 6 nM) [1]. |
In vivo | Vercirnon (50?mg/kg c.c. twice daily) blocks the colitis-associated weight loss inherent in the mdr1a?/? model and also abrogates growth arrest in the colitis mdr1a ?/? mice. Vercirnon (10, 50 mg/kg twice daily) protects from the severe inflammation associated with TNF-α overexpression in the TNFΔARE Mouse Model [2]. |
別名 | CCX282-B, GSK-1605786, Traficet-EN |
分子量 | 444.93 |
分子式 | C22H21ClN2O4S |
CAS No. | 698394-73-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (33.71 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Vercirnon 698394-73-9 Immunology/Inflammation Microbiology/Virology CCR chemotaxis CCX282-B bioavailable oral inhibit GSK-1605786 inflammatory Inhibitor bowel GSK 1605786 chemokine CC chemokine receptor Traficet-EN GSK1605786 disease inhibitor