|
T22437 |
Tazofelone
|
LY-213829 |
Others
|
|
Tazofelone (LY-213829) is a NSAID used for the treatment of inflammatory bowel disease. |
|
T1460 |
Dicyclomine hydrochloride
|
|
AChR
|
|
Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence. |
|
T5491 |
GSK3179106
|
|
c-RET
|
|
GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM |
|
T1752 |
NS6180
|
|
Potassium Channel
|
|
NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation. |
|
T64336 |
Izilendustat
|
|
HIF/HIF Prolyl-Hydroxylase
|
|
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis. |
|
T11179 |
Elubrixin
|
SB-656933 |
IL Receptor
,
CXCR
|
|
Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat... |
|
T1006 |
Propantheline bromide
|
Neopepulsan,Pro-Banthine,Neometantyl |
AChR
|
|
Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromid... |
|
T4084 |
Sibofimloc
|
VRT-1353385,Antibiotic-202,Antibiotic 202 |
Antibacterial
,
Antibiotic
|
|
Sibofimloc (Antibiotic-202), an antibiotic compound, is used in treating bacterial infections. |
|
T22338 |
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
|
GDC046 |
Others
,
JAK
|
|
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile. |
|
T17225 |
Vercirnon
|
CCX282-B,GSK-1605786,Traficet-EN |
CCR
|
|
Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases. |
|
T64337 |
PF-04745637
|
PF4745637,PF 4745637,PF 04745637,PF-4745637 |
TRP/TRPV Channel
|
|
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1]. |
|
T13385 |
Zamifenacin fumarate
|
UK-76654 fumarate |
AChR
|
|
Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor. |
|
T4691 |
Asimadoline hydrochloride
|
EMD-61753 hydrochloride |
Opioid Receptor
|
|
Asimadoline hydrochloride (EMD-61753 hydrochloride) is a κ-opioid receptor agonist potentially for the treatment of pruritus. Asimadoline hydrochloride has also been shown to be used in the treatment of irritable bowel s... |
|
T2601 |
Vidofludimus
|
SC12267,4sc-101 |
Dehydrogenase
,
DNA/RNA Synthesis
,
Interleukin
|
|
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH). |
|
T1551 |
Tegaserod maleate
|
HTF-919,SDZ-HTF-919 |
5-HT Receptor
|
|
Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ... |
|
T4633 |
Asimadoline
|
EMD-61753 |
Opioid Receptor
|
|
Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline... |
|
T19379 |
Ipsalazide
|
|
Autophagy
|
|
Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease. |
|
T14551 |
Bevenopran
|
CB-5945,ADL-5945 |
Opioid Receptor
|
|
Bevenopran (CB-5945) is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction. |
|
T27138 |
Declopramide
|
OXI-104,IMO-B,3-Chloroprocainamide |
Apoptosis
|
|
Declopramide (OXI-104) is a novel chemosensitizer with antitumor activity that induces apoptosis and can be used to study colorectal cancer and inflammatory bowel disease. |
|
T24997 |
ABT-510 acetate
|
ABT 510 acetate |
Apoptosis
|
|
ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i... |
|
T28698 |
SC-22716
|
SC 22716,SC22716 |
Aminopeptidase
|
|
SC-22716 is an orally active leukotriene A4 (LTA4) hydrolase inhibitor.SC-22716 has potential anti-inflammatory activity and may be used in the study of inflammatory bowel disease and psoriasis. |
|
T4562L |
Ramosetron hydrochloride
|
YM 060,YM-060,YM060 |
5-HT Receptor
|
|
Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea. |
|
T20615 |
Olsalazine
|
Dipentium,Salicylic acid |
Others
|
|
Olsalazine (Dipentium), an anti-inflammatory drug, is used in the treatment of inflammatory bowel disease. It is also a novel DNA hypomethylating agent. |
|
T28043L |
Minesapride
|
|
5-HT Receptor
|
|
Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation. |
|
T11852 |
リナクロチド
|
|
Guanylate cyclase
|
|
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist. |
|
T14932L |
Ceruletide Ammonium acetate
|
FI-6934 Ammonium acetate,Caerulein Ammonium acetate,Ceruletide Ammonium acetate (17650-98-5 free base) |
cholecystokinin
|
|
Ceruletide Ammonium acetate (FI-6934 Ammonium acetate) is a cholecystokinin (CCK) receptor agonist. Ceruletide Ammonium acetate is a safe and effective cholecystokinetic agent and small bowel and exocrine pancreatic stim... |
|
T22577 |
Antalarmin hydrochloride
|
|
CRFR
,
Immunology/Inflammation related
|
|
Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel... |
|
T11492 |
GSK2983559 free acid
|
|
Others
,
RIP kinase
|
|
GSK2983559 free acid is a specific and orally bioavailable inhibitor of receptor-interacting protein 2 (RIP2) kinase. It has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inf... |
|
T4319 |
Hispidol
|
(Z)-Hispidol |
TNF
|
|
Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM. |
|
T0918 |
Trimebutine
|
Mebutin |
Opioid Receptor
|
|
Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritabl... |
|
T6414 |
Bisacodyl
|
Fenilaxan,Dulcolax,Brocalax |
Others
|
|
Bisacodyl (Fenilaxan) is a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. |
|
T38507 |
Renzapride
|
BRL 24924 |
5-HT Receptor
|
|
Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS). |
|
T69984 |
Ticalopride
|
|
5-HT Receptor
|
|
Ticalopride is a 5-HT3 receptor agonist used in the treatment of digestive disorders, orofacial disorders, otorhinolaryngologic disorders, and may be used in the study of bulimia nervosa, gastroesophageal reflux, and irr... |
|
T60145 |
CCR6 antagonist 1
|
|
CCR
|
|
CCR6 antagonist 1, a chemical compound acting as a CCR6 antagonist, effectively inhibits the CCL20/CCR6 axis. Its utility lies in research focused on autoimmune-mediated inflammatory diseases, including inflammatory bowe... |
|
T60680 |
Tegaserod
|
|
5-HT Receptor
|
|
Tegaserod is an orally available 5-HT4R agonist and 5-HT2B receptor antagonist with inhibitory effects on various 5-hydroxytryptamine receptors. Tegaserod has antitumor activity and is used in the treatment of irritable ... |
|
T12970 |
Solabegron
|
GW 427353 |
Adrenergic Receptor
|
|
Solabegron (GW 427353) is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladd... |
|
T79600 |
Zharp2-1
|
|
RIP kinase
|
|
Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-induced peritonitis symptoms in mice, which can be used for ... |
|
T5095 |
Oxazolone
|
4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one |
Others
|
|
Oxazolone has been used as a haptenizing agent, which can induce an inflammatory reaction in adult zebrafish intestinal tissues and this can be used as a model for gene expression studies of the two forms of inflammatory... |
|
T9975 |
GPR183
|
3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide |
Others
|
|
GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholes... |
|
T0786 |
Clidinium bromide
|
Ro 2-3773 |
AChR
|
|
Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can... |
|
T10865 |
Cot inhibitor-1
|
|
TNF
,
MAPK
|
|
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a... |
|
T4562 |
Ramosetron
|
|
5-HT Receptor
|
|
Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondanse... |
|
T21967 |
MEG hemisulfate
|
Mercaptoethylguanidine hemisulfate |
NOS
|
|
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS i... |
|
T4615 |
Balsalazide sodium hydrate
|
Balsalazide disodium dihydrate,Balsalazide disodium salt dihydrate,Balsalazide disodium |
STAT
,
Interleukin
|
|
Balsalazide sodium hydrate (Balsalazide disodium) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide sodium hydrate is a new 5-aminosalicylic acid (5-ASA) containing prodrug.... |
|
T13647 |
Dextran sulfate sodium salt (MW 4500-5500)
|
DSS,Dextran sulfate sodium salt (MW 4500-5500) |
Apoptosis
,
HIV Protease
|
|
Dextran sulfate sodium salt (MW 4500-5500) is an anhydrous glucose polymer with a molecular weight range of 4500-5500. Dextran sulfate sodium salt (MW 4500-5500) inhibits human immunodeficiency virus replication by preve... |
|
T30936 |
Cilansetron Hydrochloride
|
KC-9946,KC9946,KC 9946 |
|
|
Cilansetron Hydrochloride can be used for irritable Bowel Syndrome (IBS) with Diarrhea Predominance. |
|
T30236L |
Axelopran sulfate
|
|
|
|
Axelopran sulfate is used in Oral Therapies for Opioid-induced Bowel Dysfunction in Patients with Chronic Noncancer Pain. |
|
T17283 |
Zamifenacin
|
UK-76654 |
Others
|
|
Zamifenacin obviously decreases colonic motility in irritable bowel syndrome. Zamifenacin is an effective gut-selective muscarinic M3 receptor antagonist. |
|
T34126 |
Prednisolone sodium metazoate
|
|
|
|
Prednisolone sodium metazoate is used in the treatment of Inflammatory Bowel Disease, Ulcerative Colitis, and GI Disorders. |
|
T14966 |
Cimetropium Bromide
|
DA-3177 |
AChR
|
|
|
