Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.
説明 | ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9. |
ターゲット&IC50 | NEK6:3.4 μM |
In vitro | In ovarian cancer cells PEO1, ZINC05007751 induced perturbation of the cell cycle. ZINC05007751 showed synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1 µM, with a combination of ZINC05007751 (44 µM) + Cisplatin (10 µM) exhibiting the greatest synergistic effect. ZINC05007751 (6 μM-190 μM; 24 hours) inhibited the growth of MDA-MB-231, PEO1, NCI-H1299, and HCT-15 with IC50 below 100 µM[1]. |
分子量 | 304.3 |
分子式 | C18H12N2O3 |
CAS No. | 591239-68-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/mL (26.29 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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ZINC05007751 591239-68-8 MAPK HCT-15 NCI-H1299 PEO1 ovarian Inhibitor ZINC 05007751 inhibit ZINC-05007751 cells NEK6 antiproliferative inhibitor