Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 7,000 | |||
50 mg | 在庫あり | ¥ 10,000 | |||
100 mg | 在庫あり | ¥ 14,000 | |||
200 mg | 在庫あり | ¥ 18,500 | |||
500 mg | 在庫あり | ¥ 30,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to reverse transcriptase terminated synthesis of viral DNA chain. |
In vitro | Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain[1]. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells[2]. |
別名 | Dideoxycytidine, ddC, NSC 606170, Ro 24-2027/000, 2',3'-Dideoxycytidine |
分子量 | 211.22 |
分子式 | C9H13N3O3 |
CAS No. | 7481-89-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (78.92 mM)
You can also refer to dose conversion for different animals. 詳細
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Zalcitabine 7481-89-2 Microbiology/Virology Proteases/Proteasome Reverse Transcriptase HIV Protease Dideoxycytidine NSC606170 NSC-606170 inhibit ddC Human immunodeficiency virus NSC 606170 HIV Ro 24-2027/000 2',3'-Dideoxycytidine Inhibitor inhibitor