Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cellular DSB repair.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 14,500 | |||
10 mg | 在庫あり | ¥ 19,500 | |||
25 mg | 在庫あり | ¥ 29,500 | |||
50 mg | 在庫あり | ¥ 43,000 | |||
100 mg | 在庫あり | ¥ 63,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,000 |
説明 | IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cellular DSB repair. |
In vitro | In CD4+CD45RO- T cells, IC 86621 (0 nM, 50 nM, 100 nM) protects rheumatoid arthritis T cells from apoptosis[1]. |
分子量 | 221.25 |
分子式 | C12H15NO3 |
CAS No. | 404009-40-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (225.99 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IC 86621 404009-40-1 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling DNA-PK ATP Buchwald-Hartwig amination Inhibitor IC-86621 DSB IC86621 antitumor inhibit Apoptosis Fries rearrangement DNA-dependent protein kinase inhibitor