Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.
説明 | JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases. |
In vitro | JNJ-67856633 is effective and highly bioavailable in both mouse and rat tumors, and in some cases led to tumor stasis. JNJ-67856633 results in potent in vivo pharmacodynamic shutdown in CD79b- as well as CARD11-mutant ABC-DLBCL models as measured by serum IL10 or uncleaved BCL10 levels in tumors[1][3]. |
In vivo | Dose dependent inhibition of the generation of Tregs (CD4+CD25+FoxP3+) following CD3/28 stimulation was observed upon treatment with JNJ-67856633 suggesting a potential immune modulatory role of MALT1 inhibition[3]. |
分子量 | 467.32 |
分子式 | C20H11F6N5O2 |
CAS No. | 2230273-76-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (267.48 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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JNJ-67856633 2230273-76-2 Immunology/Inflammation MALT inhibit active allosteric orally selective mucosa associated lymphoid tissue lymphoma translocation gene 1 Inhibitor JNJ67856633 MALT1 potent JNJ 67856633 inhibitor