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Search Results for " chalcone "

ターゲット

阻害剤

天然化合物

カタログ番号	製品名	別名	ターゲット
T10785	Chalcone 4 hydrate		Others , Parasite
	Chalcone 4 hydrate, an anti-parasite compound, inhibits the growth of Theileria and Babesia.		Others , Parasite
T24834	ß-Hydroxymethyl chalcone	Beta-Hydroxymethyl chalcone,Betahydroxymethyl chalcone,Beta Hydroxymethyl chalcone
	-Hydroxymethyl chalcone is the first selective Histone Deacetylase 2 inhibitor.
T32230	Isosalipurposide	Phlorizin chalcone
	Isosalipurposide, a chalcone compound, exerts a cytoprotective effect against oxidative injury via Nrf2 activation.
T21854	Proteasome inhibitor IX	PS-IX,AM114	Proteasome
	Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c...		Proteasome
T7432	2'-Hydroxy-2-methoxychalcone	2'-Hydroxy-2-methoxychalcone	Others , Antibacterial
	2'-Hydroxy-2-methoxychalcone is a synthetic chalcone with antibacterial activity.		Others , Antibacterial
T8829	2',4'-DIHYDROXYCHALCONE	2',4'-DHC	HSP
	2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effects		HSP
T74461	Chalcones A-N-5
	Chalcones A-N-5, a trihydroxy chalcone derivative, exhibits no cytotoxicity at concentrations below 100 µM (with IC 50 > 1 mM) and notably enhances cell proliferation. It is particularly effective in encouraging neuronal...
T124306	2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside
	2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside is a useful organic compound for research related to life sciences and the catalog number is T124306.
T33363	Metochalcone	NSC 97905,Gebyl,NSC97905,Vesidril,NSC-97905
	Metochalcone is a bioactive chemical.
T126429	2',4',6'-Trihydroxydihydrochalcone
	2',4',6'-Trihydroxydihydrochalcone is a useful organic compound for research related to life sciences and the catalog number is T126429.
T131528	4,4'-Dihydroxychalcone, 4-Methyl ether
	4,4'-Dihydroxychalcone, 4-Methyl ether is a useful organic compound for research related to life sciences and the catalog number is T131528.
T131592	2'-Hydroxy-4'-methoxychalcone
	2'-Hydroxy-4'-methoxychalcone is a useful organic compound for research related to life sciences and the catalog number is T131592.
T124697	2',4'-Dihydroxydihydrochalcone
	2',4'-Dihydroxydihydrochalcone is a useful organic compound for research related to life sciences and the catalog number is T124697.
T131522	2-Benzyloxy-2',4'-dihydroxychalcone
	2-Benzyloxy-2',4'-dihydroxychalcone is a useful organic compound for research related to life sciences and the catalog number is T131522.
T124972	2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone
	2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone is a useful organic compound for research related to life sciences and the catalog number is T124972.
T126321	2',4'-Dihydroxy-4-prenyloxychalcone
	2',4'-Dihydroxy-4-prenyloxychalcone is a useful organic compound for research related to life sciences. The catalog number is T126321 and the CAS number is 1158019-66-9.
T124078	Cyclobutanedichalcone
	Cyclobutanedichalcone is a useful organic compound for research related to life sciences and the catalog number is T124078.
T124107	Bakuchalcone
	Bakuchalcone is a useful organic compound for research related to life sciences and the catalog number is T124107.
T67707	Tyrphostin AG 538	AG 538	IGF-1R
	Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.		IGF-1R
T61472	Tubulin inhibitor 18
	Tubulin inhibitor 18 (compound 5j) is a highly potent chalcone compound that effectively inhibits tubulin. Its unique molecular structure renders Tubulin inhibitor 18 as a promising candidate for cancer research [1].
T61459	Tubulin inhibitor 19
	Tubulin inhibitor 19 (compound 9b) is a potent indole chalcone compound that exhibits strong inhibitory activity against tubulin. Its potential in cancer research makes it valuable for studying cancer diseases [1].
T73832	Tubulin inhibitor 21
	Tubulin Inhibitor 21 (compound 6f), a hybrid based on chalcone and melatonin, exhibits potent tubulin inhibition properties. It demonstrates significant cytotoxic activity against SW480 cells (IC 50 =0.26 μM) while showi...
T74712	TMV-IN-2
	TMV-IN-2, a chalcone derivative, functions as an inhibitor of the tobacco mosaic virus (TMV), exhibiting antiviral properties with an EC50 of 89.9 μg/mL. This compound is utilized in investigating infection, inflammation...
T74713	TMV-IN-3
	TMV-IN-3, a chalcone derivative, functions as a tobacco mosaic virus (TMV) inhibitor, exhibiting antiviral activity against TMV with an EC50 of 120.3 μg/mL. This compound is applicable for research in infection, inflamma...
T83046	Anti-Influenza agent 5		Influenza Virus
	Anti-Influenza agent 5 (Compound IIB-2), a chalcone-like derivative, serves as an influenza nuclear export inhibitor. It effectively inhibits oseltamivir-resistant strains and hinders viral proliferation by obstructing t...		Influenza Virus
T73379	TMV-IN-1
	TMV-IN-1, a chalcone derivative, serves as an inhibitor of the tobacco mosaic virus (TMV), demonstrating effective therapeutic and protective activities, with EC50 values of 70.7 μg/mL and 60.8 μg/mL, respectively. This ...
T60858	MOPIPP
	MOPIPP is a novel indolebased chalcone that can cross the blood-brain barrier. MOPIPP inhibits the tumor progression agaisnt glioblastoma cells. MOPIPP induces cellular vacuolization as well as increases autophagosomes n...

Compounds

Chalcone 4 hydrate

T10785

Synonym:

Target: Others, Parasite

ß-Hydroxymethyl chalcone

T24834

Synonym: Beta-Hydroxymethyl chalcone,Betahydroxymethyl chalcone,Beta Hydroxymethyl chalcone

Target:

Isosalipurposide

T32230

Synonym: Phlorizin chalcone

Target:

Proteasome inhibitor IX

T21854

Synonym: PS-IX,AM114

Target: Proteasome

2'-Hydroxy-2-methoxychalcone

T7432

Synonym: 2'-Hydroxy-2-methoxychalcone

Target: Others, Antibacterial

2',4'-DIHYDROXYCHALCONE

2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside

Synonym: NSC 97905,Gebyl,NSC97905,Vesidril,NSC-97905

Target:

2',4',6'-Trihydroxydihydrochalcone

T126429

Synonym:

Target:

4,4'-Dihydroxychalcone, 4-Methyl ether

T131528

Synonym:

Target:

2'-Hydroxy-4'-methoxychalcone

T131592

Synonym:

Target:

2',4'-Dihydroxydihydrochalcone

T124697

Synonym:

Target:

2-Benzyloxy-2',4'-dihydroxychalcone

T131522

Synonym:

Target:

2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone

T124972

Synonym:

Target:

2',4'-Dihydroxy-4-prenyloxychalcone

T126321

Synonym:

Target:

Cyclobutanedichalcone

Anti-Influenza agent 5

T83046

Synonym:

Target: Influenza Virus

カタログ番号	製品名	別名	ターゲット
T2S0961	Chalcone	benzylideneacetophenone,phenyl styryl ketone,Cinnamophenone,benzalacetophenone,β-phenylacrylophenone	EGFR , Antibacterial
	Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.		EGFR , Antibacterial
T3322	Trans-Chalcone	Chalcone,Cinnamophenone,Chalkone	Apoptosis , Others , Antifungal , Fatty Acid Synthase
	trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.		Apoptosis , Others , Antifungal , Fatty Acid Synthase
TN2078	Pinocembrin chalcone	2',4',6'-Trihydroxychalcone,Pinocembrinchalcone	Calcium Channel , Tyrosinase , Antibacterial , Antifection
			Calcium Channel , Tyrosinase , Antibacterial , Antifection
TN2083	Pinostrobin chalcone
	Pinostrobin chalcone, a chalcone analog isolated from the leguminous plant, Mucuna pruriens, exhibits anticancer activity with an IC50 value of 20.42±2.23 μg/mL against MDA-MB-231 and 22.51±0.42 μg/mL against the HT-29 c...
T7784	Naringenin chalcone	Isosalipurpol,2',4,4',6'-TETRAHYDROXYCHALCONE,Chalcononaringenin,Chalconaringenin	Others
	Naringenin chalcone (Isosalipurpol) is a product natural isolated from stems of Machaerium isadelphum (Fabaceae).		Others
T2S2173	(E)-Naringenin chalcone	Isosalipurpol,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone	Others
	Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid tha...		Others
TN7224	2,2'-Dihydroxy chalcone		Antibacterial , Autophagy
	2,2'-Dihydroxy chalcone is a potent inhibitor of β-glucuronidase (IC50=1.6±0.2 μM) and lysozyme (IC50=1.4±0.2 μM) release from rat neutrophils stimulated with fMLP/CB.2,2'-Dihydroxy chalcone has inhibitory activity again...		Antibacterial , Autophagy
TN7226	2-Hydroxy-3-methoxy chalcone
	2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
T2994	(E)-Cardamonin	Alpinetin chalcone,Cardamomin,Cardamonin,(E)-Cardamoni	Apoptosis , TRP/TRPV Channel
	(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM...		Apoptosis , TRP/TRPV Channel
TN3987	Eriodictyol chalcone		Anti-infection , Aromatase
	Eriodictyol chalcone has anti-plasmodial effects on P. falciparum growth.		Anti-infection , Aromatase
TN1895	Luteolinidin chloride		CD38
	Luteolinidin chloride is a natural product. It is a potent CD38 inhibitor which can protect the heart against I/R injury with preservation of eNOS function and prevention of endothelial dysfunction in vivo.		CD38
T38815	Millepachine		Apoptosis
	Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.		Apoptosis
T3S0737	Flavokawain A	Flavokavain A	Apoptosis , p38 MAPK
	NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...		Apoptosis , p38 MAPK
T7917	4'-Hydroxychalcone	2-Benzal-4-Hydroxyacetophenone	Proteasome
	4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity		Proteasome
T3861	Isobavachalcone	Corylifolinin,Isobacachalcone	Apoptosis , Others , Reactive Oxygen Species , Akt , Autophagy
	Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation.
TN3033	4'-Hydroxy-2,4-dimethoxychalcone		Antibacterial , Parasite , Antifungal
	4'-Hydroxy-2,4-dimethoxychalcone is a naturally occurring chalcone derivative from the herbal resin of the red geranium Dragon's Blood.4'-Hydroxy-2,4-dimethoxychalcone possesses a wide range of biological activities incl...		Antibacterial , Parasite , Antifungal
TN7225	2'-Hydroxy-3,4-dimethoxychalcone		Antioxidant , Parasite
	2'-Hydroxy-3,4-dimethoxychalcone, a chalcone compound isolated from the roots of Sophora japonica, has antioxidant activity and inhibited the intracellular survival of Lactobacillus donovani Parasite EC.50 Values ranged ...		Antioxidant , Parasite
T7985	4,4'-Dimethoxychalcone	4,4-Dimethoxychalcone	Others , Autophagy
	4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product.		Others , Autophagy
TN1055	Licochalcone E		TNF , Liver X Receptor , PPAR
	Licochalcone E is a potential LXRβ agonist.		TNF , Liver X Receptor , PPAR
T3S0136	4'-O-Methylbavachalcone	O-Methylbroussochalcone B	SARS-CoV
	4'-O-Methylbavachalcone (O-Methylbroussochalcone B) is isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity (IC50: 10.1 μM).		SARS-CoV
TN7069	2',4,4',6'-Tetramethoxychalcone	2',4,4',6'-TETRAMETHOXY	Others
	2',4,4',6'-Tetramethoxychalcone (2',4,4',6'-TETRAMETHOXY) is a natural product.		Others
T3S0137	Bavachalcone		Antibacterial , Antibiotic
	Bavachalcone is a major bioactive compounds isolated from Psoralea corylifolia L. it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect the endothelial function by increa...		Antibacterial , Antibiotic
T2761	Naringin dihydrochalcone	Naringin DC	P450 , NF-κB
	Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.		P450 , NF-κB
T7979	2-Hydroxychalcone	2-(2-Hydroxybenzal)Acetophenone	Apoptosis , BCL , Others , NF-κB
	2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells.		Apoptosis , BCL , Others , NF-κB
TN2882	3,4-Dimethoxychalcone		Others
	3,4-Dimethoxychalcone is a natural product found in Arrabidaea brachypoda flowers.		Others
T2767	Neohesperidin Dihydrochalcone	NHDC,Neohesperidin DC,NCI-c60764	Reactive Oxygen Species
	Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus.		Reactive Oxygen Species
T7443	4'-Methoxychalcone		PARP , PPAR
	4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.		PARP , PPAR
T4S0350	Licochalcone B		Beta Amyloid , Others
	1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licoc...		Beta Amyloid , Others
T8015	4-METHOXYCHALCONE	2-(4-Methoxybenzal)Acetophenone	Others
	4-METHOXYCHALCONE (2-(4-Methoxybenzal)Acetophenone) is a natural compound that enhanced adipocyte differentiation,		Others
T4518	Licochalcone D		ERK , NF-κB
	Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect...		ERK , NF-κB
T3005	4-Hydroxychalcone	P-Cinnamoylphenol	Others , NF-κB
	4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.		Others , NF-κB
T7028	Licochalcone C	LICOCHALCONEC	Phosphatase , Antioxidant , Glucosidase
	Licochalcone C (LICOCHALCONEC) has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activit...		Phosphatase , Antioxidant , Glucosidase
T3600	Licochalcone A		Caspase , UGT , Autophagy
	Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.		Caspase , UGT , Autophagy
TN1163	2'-Hydroxychalcone		Others
	2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxyc...		Others
T83407	2',3'-Dihydroxy-4',6'-dimethoxychalcone
	2',3'-Dihydroxy-4',6'-dimethoxychalcone (compound 1) possesses the capacity to inhibit Amyloid β-protein (Aβ42) fibrillization and aggregation, demonstrating oral activity with detectable presence in the brain [1].
T74203	Licoagrochalcone C
	Licoagrochalcone C, a flavonoid compound, demonstrates potent inhibitory effects on NF-κB transcription and significantly reduces LPS-induced NO production, showcasing its bioactive properties [1] [2].
TN6377	2'-Hydroxy-3',4',6'-trimethoxychalcone
	2'-Hydroxy-3',4',6'-trimethoxychalcone is a natural product for research related to life sciences. The catalog number is TN6377 and the CAS number is 91856-16-5.
TN6147	Tetrahydroxymethoxychalcone	3,4,3',4'-Tetrahydroxy-2-methoxychalcone
	Tetrahydroxymethoxychalcone is a natural product for research related to life sciences. The catalog number is TN6147 and the CAS number is 197227-39-7.
TN3000	4,2'-Dihydroxy-4'-methoxychalcone		Others
	4,2'-Dihydroxy-4'-methoxychalcone shows allergy-preventive effects.		Others
TN1245	3-Deoxysappanchalcone		Others , Akt , mTOR
	3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.		Others , Akt , mTOR
TN2180	Sappanchalcone		IL Receptor , BCL , TNF
	Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.		IL Receptor , BCL , TNF
TN2718	2,4-Dihydroxy-4,6-dimethoxydihydrochalcone		Others
	2,4-Dihydroxy-4,6-dimethoxydihydrochalcone is a natural product for research related to life sciences. The catalog number is TN2718 and the CAS number is 75679-58-2.		Others
TN2854	3,2'-Dihydroxy-4,4'-dimethoxychalcone		Others
	3,2'-Dihydroxy-4,4'-dimethoxychalcone is a natural product for research related to life sciences. The catalog number is TN2854 and the CAS number is 2567-65-9.		Others
TN2714	2',4'-Dihydroxy-3',6'-dimethoxychalcone		Others
	2',4'-Dihydroxy-3',6'-dimethoxychalcone has cytotoxic, anti-inflammatory activity and anti-cholinesterase activities, it has significant NO inhibitory activity.		Others
T13970	Xinjiachalcone A		Others
	Xinjiachalcone A is a natural product isolated from Glycyrrhiza inflata Batalin. Xinjiachalcone A shows both a low MIC and a strong bactericidal activity against H. pylori(MIC : 12.5 to 50 µM, seventeen H. pylori strains...		Others
TN6378	2'-Hydroxy-3',4',6'-trimethoxydihydrochalcone
	2'-Hydroxy-3',4',6'-trimethoxydihydrochalcone is a natural product for research related to life sciences. The catalog number is TN6378 and the CAS number is 1222818-87-2.
T39003	4',2-Dihydroxy-4,6-dimethoxydihydrochalcone
	4',2-Dihydroxy-4,6-dimethoxydihydrochalcone, an estrogen agonist, exhibits a significant binding affinity for the estrogen receptor in bovine uterine tissue, with an IC50 value of 15 μM.
TN7116	6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone		Others
	6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone is an alkenylphenol from Piper obliquum with antiinflammatory and antibacterial activities.		Others
T72594	Broussochalcone A
	Broussochalcone A, an antioxidant and Xanthine Oxidase inhibitor (IC 50 =2.21 μM), exhibits free radical scavenging activity. It prevents iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (...
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