Powder: -20°C for 3 years | In solvent: -80°C for 1 year
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the biosynthesis of serotonin may contribute to the characterization of the role of serotonin in behavioral and physiological activities[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 8,000 | |||
25 mg | 在庫あり | ¥ 13,000 | |||
50 mg | 在庫あり | ¥ 18,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 20,500 |
説明 | p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the biosynthesis of serotonin may contribute to the characterization of the role of serotonin in behavioral and physiological activities[1]. |
ターゲット&IC50 | TPH:32.6 μM |
In vitro | p-Ethynylphenylalanine hydrochloride was demonstrated to inhibit competitively and reversibly TPH in vitro (Ki = 32.6 +/- 6.2 microM vs. tryptophan)[1]. |
In vivo | Administration of p-Ethynylphenylalanine hydrochloride (30 mg/kg) to rats produced a 95 +/- 5% decrease in TPH activity in brain homogenates and a concomitant decrease in serotonin and 5-hydroxyindole-3-acetic acid levels (85%) at 24 h after injection[1]. |
別名 | 4-Ethynyl-L-phenylalanine HCL, p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) |
分子量 | 225.67 |
分子式 | C11H12ClNO2 |
CAS No. | 188640-63-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 12 mg/mL (53.17 mM), Sonication is recommended.
DMSO: 99 mg/mL (438.69 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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p-Ethynylphenylalanine hydrochloride 188640-63-3 Metabolism Hydroxylase p-Ethynylphenylalanine p Ethynylphenylalanine hydrochloride 4-Ethynyl-L-phenylalanine HCL 5-HT inhibit 5-HIAA Tryptophan Hydroxylase hydroxylase p-Ethynylphenylalanine Hydrochloride Inhibitor tryptophan serotonin p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) TPH pEthynylphenylalanine hydrochloride inhibitor