| TN2437 |
Serotonin
|
5-hydroxytryptamine,5-HT |
Others
,
5-HT Receptor
,
Endogenous Metabolite
,
Transferase
|
|
Serotonin (5-hydroxytryptamine) is a natural product from animals |
| T2209 |
Serotonin hydrochloride
|
5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride |
5-HT Receptor
,
Endogenous Metabolite
,
Transferase
|
|
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). |
| TN1969 |
N-(p-Coumaroyl) serotonin
|
|
PDGFR
|
|
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving... |
| T4860 |
5-Hydroxytryptamine creatinine sulfate monohydrate
|
Serotonin creatinine sulfate monohydrate,5-Hydroxytryptamine creatinine sulfate complex |
Others
,
Endogenous Metabolite
|
|
5-Hydroxytryptamine creatinine sulfate monohydrate (Serotonin creatinine sulfate monohydrate) is a neurotransmitter. |
| T19931 |
Gentisein
|
NSC 329491,NSC329491,NSC-329491 |
Serotonin Transporter
|
|
Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7 µM[1][2]. |
| T2815 |
Puerarin
|
Kakonein |
5-HT Receptor
|
|
Puerarin (Kakonein), also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist. |
| T9113 |
Myristicin
|
Myristicine |
IL Receptor
,
Anti-infection
,
BCL
,
P450
,
PARP
,
5-HT Receptor
,
Caspase
,
GABA Receptor
,
NO Synthase
|
|
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ... |
| T0525 |
Flopropione
|
Phloropropiophenone |
5-HT Receptor
,
Transferase
|
|
Flopropione (Phloropropiophenone), a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist. |
| T6S0654 |
Isocorynoxeine
|
7-Isocorynoxeine |
5-HT Receptor
|
|
1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ... |
| TN1032 |
Geissoschizine methyl ether
|
|
5-HT Receptor
|
|
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a potent serotonin A receptor agonist and ca... |
| T7521 |
Azaphen
|
Pipofezin hydrochloride,Pipofezine hydrochloride,Azafen |
5-HT Receptor
,
Serotonin Transporter
|
|
Azaphen (Pipofezin hydrochloride) is the reuptake of serotonin inhibitor.with antidepressant action and has sedative effects, suggesting antihistamine activity. |
| T4S1637 |
Gamma-Mangostin
|
Normangostin |
Others
,
5-HT Receptor
|
|
1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ... |
| TN1217 |
2'-O-Methylisoliquiritigenin
|
|
Dopamine Receptor
,
5-HT Receptor
,
GABA Receptor
|
|
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a ... |
| TN1465 |
Cannabigerol
|
|
NOS
,
5-HT Receptor
,
ROS
|
|
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... |
| T1045 |
Trimipramine maleate
|
Surmontil maleate |
Dopamine Receptor
,
5-HT Receptor
,
Antibacterial
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal... |
| T6648 |
Rotundine
|
Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine |
Dopamine Receptor
,
5-HT Receptor
|
|
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
| T3369 |
Nuciferine
|
(-)-Nuciferine,VLT 049,Sanjoinine E |
Dopamine Receptor
,
5-HT Receptor
|
|
Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. |
| T1711 |
Harmine
|
Telepathine |
MAO
,
5-HT Receptor
,
DYRK
|
|
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala. |
| T0076 |
Paliperidone
|
9-hydroxyrisperidone |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older... |
| T1317 |
Cinchonidine
|
α-Quinidine,L-Cinchonidine |
5-HT Receptor
,
Serotonin Transporter
,
Parasite
|
|
Cinchonidine (L-Cinchonidine) is an alkaloid extracted from Cinchona officinalis. It is a pseudo-enantiomer and stereoisomer of cinchonine. |
| TN2865 |
(E)-3,4,5-Trimethoxycinnamic acid
|
O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid |
Others
|
|
(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum. |
| T2811 |
Harmine hydrochloride
|
telepathine hydrochloride |
5-HT Receptor
,
DYRK
,
GluR
|
|
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus. |
| T3933 |
Jatrorrhizine
|
Yatrorizine,neprotin |
MAO
,
5-HT Receptor
,
Antibacterial
,
AChE
|
|
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo... |
| T0185 |
Escitalopram
|
Seroplex,S-(+)-Citalopram,(S)-Citalopram |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Histamine Receptor
|
|
Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patien... |
| T1156 |
Palonosetron hydrochloride
|
RS 25259 197,Palonosetron HCl,RS 25259 |
5-HT Receptor
|
|
Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
| T4S1659 |
Xanthotoxol
|
8-Hydroxypsoralen,8-Hydroxyfuranocoumarin,Psoralen,8-Hydroxypsoralene |
Reactive Oxygen Species
,
5-HT Receptor
,
Endogenous Metabolite
|
|
Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects. |
| T4912 |
Jatrorrhizine chloride
|
Yatrorhizine chloride,Neprotine chloride |
Others
,
5-HT Receptor
,
OCT
,
Antibacterial
,
AChE
|
|
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... |
| TMA1122 |
N-Feruloylserotonin
|
(E/Z)-Moschamine,Moschamine |
Antioxidant
|
|
N-Feruloylserotonin ((E/Z)-Moschamine) is a selective FAAH inhibitor that inhibits [H]-AEA uptake and cell proliferation at low concentrations. |
| T82808 |
Bufoserotonin C
|
|
|
|
Bufoserotonin C, an indole alkaloid derived from the traditional Chinese medicine Chansu, exhibits antitumor activity and demonstrates an IC50 value of 34.3 μM in A549 cells [1] [2]. |
| T4744 |
5-HYDROXYINDOLE-3-ACETIC ACID
|
5-HIAA |
Others
,
Endogenous Metabolite
|
|
5-Hydroxyindole-3-acetic acid (5-HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be meas... |
| T4761 |
Pyridoxal hydrochloride
|
|
Others
,
Endogenous Metabolite
|
|
The 4-carboxyaldehyde form of vitamin B6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. |
| T3003 |
5-hydroxytryptophan
|
NSC-92523 |
Others
,
Endogenous Metabolite
|
|
5-hydroxytryptophan (NSC-92523) is the immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant. |
| T1354 |
N-Acetyl-5-hydroxytryptamine
|
Normelatonin,O-Demethylmelatonin,N-Acetylserotonin |
Trk receptor
,
Endogenous Metabolite
|
|
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to m... |
| T0783 |
Mianserin hydrochloride
|
Mianserin HCl,Org GB 94,ORG GB-94 HCl |
Dopamine Receptor
,
5-HT Receptor
,
Opioid Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematolog... |
| T13515 |
5-Methoxytryptophol
|
2-(5-Methoxy-1H-indol-3-yl)ethanol,Methoxytryptophol |
Endogenous Metabolite
|
|
5-Methoxytryptophol (2-(5-Methoxy-1H-indol-3-yl)ethanol) is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species. |
| TN1740 |
Homoeriodictyol
|
|
5-HT Receptor
,
transporter
,
Sodium Channel
,
Drug Metabolite
|
|
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotoni... |
| T0973L |
Pyridoxine hydrochloride
|
Pyridoxine HCl,Pyridoxol (hydrochloride),Vitamin B6 (hydrochloride),Vitamin B6 |
Nrf2
,
Endogenous Metabolite
|
|
Pyridoxine hydrochloride (Vitamin B6) is the 4-methanol form of vitaminB6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingo... |
| TN1370 |
Allura Red AC
|
Allura Red,CI 16035,FD&C RED NO. 40 |
Others
,
Estrogen/progestogen Receptor
,
Androgen Receptor
|
|
Allura Red AC (CI 16035) is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal seroto... |
| T0439 |
L-Tryptophan
|
(S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane |
Amino Acids and Derivatives
,
Endogenous Metabolite
|
|
L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid) and of ... |
| T1379 |
L-5-Hydroxytryptophan
|
L-oxitriptan,Oxitriptan,L-5-HTP |
Amino Acids and Derivatives
,
Endogenous Metabolite
|
|
L-5-Hydroxytryptophan (L-5-HTP) is the immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant. |
| T0791 |
Reserpine
|
Serpalan,Serpasil,Serpivite |
Others
,
Potassium Channel
,
MRP
,
Monoamine Transporter
,
Autophagy
|
|
Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotoni... |
| T4429 |
Rauwolscine hydrochloride
|
Corynanthidine hydrochloride,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride |
Adrenergic Receptor
|
|
Rauwolscine hydrochloride (Isoyohimbine hydrochloride) , a natural alkaloid, is a specific and reversible α2-adrenergic receptor antagonist (Ki: 12 nM) [1]. It is a stereoisomer of yohimbine, which potently antagonizes b... |
| T1311 |
4-aminobenzoic acid
|
PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid |
Endogenous Metabolite
|
|
4-aminobenzoic acid (para-Aminobenzoic acid) is an organic acid with UV absorption and antifibrotic properties. When exposed to light, 4-aminobenzoic acid absorbs UV light and emits excess energy via a photochemical reac... |
| T6S1684 |
8-Gingerol
|
|
Antioxidant
,
Antibacterial
,
TRP/TRPV Channel
|
|
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic... |
| T28019 |
(-)-Mesembrine
|
Mesembrin,Mesembrine,Mesembranone |
|
|
Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4). |
| T19772 |
Mesembrenone
|
(+)-Mesembrenone |
|
|
Mesembrenone is a selective the serotonin transporter (SERT) inhibitor. Mesembrenone is the main alkaloid of Sceletium tortuosum. |
| TN1623 |
Escin IIB
|
|
Others
,
NOS
|
|
Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching behavior induced by compound 48/80 in mice. |
| T36532 |
SCH 38519
|
|
|
|
SCH 38519 is an isochromanequinone fungal metabolite originally isolated from Thermomonospora. It inhibits aggregation induced by thrombin , as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 μ... |
| T75436 |
Jatrorrhizine hydroxide
|
|
|
|
Jatrorrhizine hydroxide, an alkaloid derived from Coptis chinensis, exhibits a range of biological activities including neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties [1]. It acts as a potent ... |
