| T2209 |
Serotonin hydrochloride
|
5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride |
5-HT Receptor
,
Endogenous Metabolite
,
Transferase
|
|
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). |
| TN2437 |
Serotonin
|
5-hydroxytryptamine,5-HT |
Others
,
5-HT Receptor
,
Endogenous Metabolite
,
Transferase
|
|
Serotonin (5-hydroxytryptamine) is a natural product from animals |
| T2815 |
Puerarin
|
Kakonein |
5-HT Receptor
|
|
Puerarin (Kakonein), also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist. |
| T9113 |
Myristicin
|
Myristicine |
IL Receptor
,
Anti-infection
,
BCL
,
P450
,
PARP
,
5-HT Receptor
,
Caspase
,
GABA Receptor
,
NO Synthase
|
|
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ... |
| T0525 |
Flopropione
|
Phloropropiophenone |
5-HT Receptor
,
Transferase
|
|
Flopropione (Phloropropiophenone), a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist. |
| T6S0654 |
Isocorynoxeine
|
7-Isocorynoxeine |
5-HT Receptor
|
|
1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ... |
| T1045 |
Trimipramine maleate
|
Surmontil maleate |
Dopamine Receptor
,
5-HT Receptor
,
Antibacterial
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal... |
| T4S1659 |
Xanthotoxol
|
8-Hydroxypsoralen,8-Hydroxyfuranocoumarin,Psoralen,8-Hydroxypsoralene |
Reactive Oxygen Species
,
5-HT Receptor
,
Endogenous Metabolite
|
|
Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects. |
| TN1032 |
Geissoschizine methyl ether
|
|
5-HT Receptor
|
|
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a potent serotonin A receptor agonist and ca... |
| T4S1637 |
Gamma-Mangostin
|
Normangostin |
Others
,
5-HT Receptor
|
|
1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ... |
| TN1217 |
2'-O-Methylisoliquiritigenin
|
|
Dopamine Receptor
,
5-HT Receptor
,
GABA Receptor
|
|
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a ... |
| T6648 |
Rotundine
|
Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine |
Dopamine Receptor
,
5-HT Receptor
|
|
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
| TN1465 |
Cannabigerol
|
|
NOS
,
5-HT Receptor
,
ROS
|
|
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... |
| T19931 |
Gentisein
|
NSC 329491,NSC329491,NSC-329491 |
Serotonin Transporter
|
|
Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7 µM[1][2]. |
| T3369 |
Nuciferine
|
(-)-Nuciferine,VLT 049,Sanjoinine E |
Dopamine Receptor
,
5-HT Receptor
|
|
Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. |
| T1711 |
Harmine
|
Telepathine |
MAO
,
5-HT Receptor
,
DYRK
|
|
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala. |
| T0076 |
Paliperidone
|
9-hydroxyrisperidone |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older... |
| T2811 |
Harmine hydrochloride
|
telepathine hydrochloride |
5-HT Receptor
,
DYRK
,
GluR
|
|
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus. |
| T3933 |
Jatrorrhizine
|
Yatrorizine,neprotin |
MAO
,
5-HT Receptor
,
Antibacterial
,
AChE
|
|
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo... |
| T4912 |
Jatrorrhizine chloride
|
Yatrorhizine chloride,Neprotine chloride |
Others
,
5-HT Receptor
,
OCT
,
Antibacterial
,
AChE
|
|
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... |
| TN2865 |
(E)-3,4,5-Trimethoxycinnamic acid
|
O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid |
Others
|
|
(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum. |
| T3410 |
Momordin Ic
|
Momordin 1c |
Apoptosis
,
MAPK
,
PI3K
|
|
Momordin Ic (Momordin 1c) might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways. A... |
| T37067 |
9-hydroxy Stearic Acid
|
|
HDAC
|
|
9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (... |
| TN2030 |
P-Hydroxyphenethyl trans-ferulate
|
|
5-HT Receptor
|
|
P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone reductase specific activity in Hepa 1c1c7 cells at a level... |
| TN2116 |
Pteropodine
|
|
BCL
,
Calcium Channel
,
5-HT Receptor
|
|
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows strong apoptotic effect on acute leukaemic l... |
| T73857 |
Mesembrine
|
|
|
|
Mesembrine ((+)-Mesembrine), a primary alkaloid distinguished by its aryloctahydroindole structure, acts as a potent 5-HT transporter inhibitor with an inhibition constant (K i) of 1.4 nM. Additionally, it demonstrates i... |
| TN4092 |
Galanolactone
|
|
5-HT Receptor
|
|
Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. Galanolactone ex... |
| TN2533 |
1-Hydroxy-2,3,4,7-tetramethoxyxanthone
|
|
5-HT Receptor
|
|
1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-... |
| T75436 |
Jatrorrhizine hydroxide
|
|
|
|
Jatrorrhizine hydroxide, an alkaloid derived from Coptis chinensis, exhibits a range of biological activities including neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties [1]. It acts as a potent ... |
| T37911 |
Cis-Resveratrol
|
(Z)-Resveratrol |
|
|
Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, ... |
